Therapeutic use of n-(arylalkyl)-1h-pyrrolopyridine-2-carboxamide derivatives

Abstract

The invention concerns therapeutic use of compounds of general formula (I), wherein n, the pyrrolopyridine ring, X 1 , Z 1 , Z 2 , Z 3 , Z 4 , Z 5 and W are as defined herein.

1 . A method for treating pain, inflammation, urological disorder, gynecological disorder, gastrointestinal disorder, respiratory disorder, psoriasis, pruritus, dermal, ocular or mucous irritation, herpes or zona, comprising administering to a patient in need of said treatment a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof: 
       
         
           
           
               
               
           
         
         wherein: 
         n is equal to 0, 1, 2 or 3; 
         the pyrrolopyridine nucleus is a pyrrolo[3,2-b]pyridine group, a pyrrolo[3,2-c]pyridine group, a pyrrolo[2,3-c]pyridine group or a pyrrolo[2,3-b]pyridine group; 
         X is chosen from a halogen atom and a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, C 1 -C 6 -alkoxyl, C 1 -C 6 -fluoroalkoxyl, cyano, C(O)NR 1 R 2 , nitro, NR 1 R 2 , C 1 -C 6 -thioalkyl, —S(O)—C 1 -C 6 -alkyl, —S(O) 2 —C 1 -C 6 -alkyl, SO 2 NR 1 R 2 , NR 3 COR 4 , NR 3 SO 2 R 5  or aryl group, the aryl being optionally substituted with one or more substituents chosen from a halogen and a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, C 1 -C 6 -alkoxyl, C 1 -C 6 -fluoroalkoxyl, nitro or cyano group; 
         Z 1 , Z 2 , Z 3 , Z 4  and Z 5  represent, independently of each other, a hydrogen or halogen atom or a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, C 1 -C 6 -alkoxyl, C 1 -C 6 -fluoroalkoxyl, cyano, C(O)NR 1 R 2 , nitro, NR 1 R 2 , C 1 -C 6 -thioalkyl, —S(O)—C 1 -C 6 -alkyl, —S(O) 2 —C 1 -C 6 -alkyl, SO 2 NR 1 R 2 , NR 3 COR 4 , NR 3 SO 2 R 5,  aryl-C 1 -C 6 -alkylene or aryl group, the aryl and the aryl-C 1 -C 6 -alkylene being optionally substituted with one or more substituents chosen from a halogen and a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, C 1 -C 6 -alkoxyl, C 1 -C 6 -fluoroalkoxyl, nitro or cyano group; and wherein
 R 1  and R 2  represent, independently of each other, a hydrogen atom or a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, aryl-C 1 -C 6 -alkylene or aryl group; or R 1  and R 2  together forming, with the nitrogen atom that bears them, an azetidine, pyrrolidine, piperidine, azepine, morpholine, thiomorpholine, piperazine, homopiperazine group, this group being optionally substituted with a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, aryl-C 1 -C 6 -alkylene or aryl group; 
 R 3  and R 4  represent, independently of each other, a hydrogen atom or a C 1 -C 6 -alkyl, aryl-C 1 -C 6 -alkylene or aryl group; 
 R 5  represents a C 1 -C 6 -alkyl or aryl group; and 
 
         W represents a fused bicyclic group of formula: 
       
       
         
           
           
               
               
           
         
         bonded to the nitrogen atom via positions 1, 2, 3 or 4; wherein
 A represents a 5- to 7-membered heterocycle comprising from one to three heteroatoms chosen from O, S and N;
 the carbon atom(s) of A being optionally substituted with one or more groups chosen from a hydrogen atom and a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, aryl, aryl-C 1 -C 6 -alkylene, oxo or thio group; and 
 the nitrogen atom(s) of A being optionally substituted with R 6  when the nitrogen is adjacent to a carbon atom substituted with an oxo group, or with R 7  in the other cases; wherein 
 
 R 6  represents a hydrogen atom or C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, aryl-C 1 -C 6 -alkylene or aryl group; 
 R 7  represents a hydrogen atom or a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, aryl-C 1 -C 6 -alkylene, C 1 -C 6 -alkyl-C(O)—, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene-(CO)—, C 1 -C 6 -fluoroalkyl-C(O)—, C 3 -C 7 -cycloalkyl-C(O)—, aryl-C(O)—, aryl-C 1 -C 6 -alkylene-C(O)—, C 1 -C 6 -alkyl-S(O) 2 —, C 1 -C 6 -fluoroalkyl-S(O) 2 —, C 3 -C 7 -cycloalkyl-S(O) 2 —, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene-S(O) 2 —, aryl-S(O) 2 — or aryl-C 1 -C 6 -alkylene-S(O) 2 — or aryl group; 
 
         the sulfur atom(s) of the heterocycle A possibly being in oxidized form; 
         the nitrogen atom(s) of the heterocycle A possibly being in oxidized form; and 
         the nitrogen atom in position 4, 5, 6 or 7 of the pyrrolopyridine may be in oxidized form. 
       
     
     
         2 . The method according to  claim 1 , wherein in compound of formula (I) n is equal to 1 or 2. 
     
     
         3 . The method according to  claim 1 , wherein in compound of formula (I) the pyrrolopyridine nucleus is a pyrrolo[3,2-b]pyridine group, a pyrrolo[3,2-c]pyridine group, a pyrrolo[2,3-c]pyridine group or a pyrrolo[2,3-b]pyridine group; and
 X is chosen from a hydrogen or halogen atom and a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 1 -C 6 -fluoroalkyl, C 1 -C 6 -alkoxyl, C 1 -C 6 -fluoroalkoxyl, nitro, NR 1 R 2 , C 1 -C 6 -thioalkyl, —S(O)—C 1 -C 6 -alkyl, —S(O) 2 —C 1 -C 6 -alkyl, or aryl group; and
 wherein 
 R 1  and R 2  are hydrogen atoms. 
   
     
     
         4 . The method according to  claim 1 , wherein in compound of formula (I) the pyrrolopyridine nucleus is a pyrrolo[3,2-b]pyridine group, a pyrrolo[3,2-c]pyridine group, a pyrrolo[2,3-c]pyridine group or a pyrrolo[2,3-b]pyridine group; and
 X is chosen from a halogen atom, a C 1 -C 6 -fluoroalkyl or aryl group.   
     
     
         5 . The method according to  claim 1 , wherein in compound of formula (I) Z 1 , Z 2 , Z 3 , Z 4  and Z 5  represent, independently of each other, a hydrogen or halogen atom. 
     
     
         6 . The method according to  claim 1 , wherein in compound of formula (I) W is chosen from indolinyl, indolyl, isoindolyl, isoindolinyl, benzofuranyl, dihydrobenzofuranyl, benzothiophenyl, dihydrobenzothiophenyl, benzoxazolyl, dihydrobenzoxazolinyl, isobenzofuranyl, dihydroisobenzofuranyl, benzimidazolyl, dihydrobenzimidazolyl, indazolyl, benzothiazolyl, isobenzothiazolyl, dihydroisobenzothiazolyl, benzotriazolyl, quinolyl, dihydroquinolyl, tetrahydroquinolyl, isoquinolyl, dihydroisoquinolyl, tetrahydroisoquinolyl, benzoxazinyl, dihydrobenzoxazinyl, benzothiazinyl, dihydrobenzothiazinyl, cinnolinyl, quinazolinyl, dihydroquinazolinyl, tetrahydroquinazolinyl, quinoxalinyl, dihydroquinoxalinyl, tetrahydroquinoxalinyl, phthalazinyl, dihydrophthalazinyl, tetrahydrophthalazinyl, tetrahydrobenz[b]azepinyl, tetrahydrobenz[c]azepinyl, tetrahydrobenz[d]azepinyl, tetrahydrobenzo[b][1,4]diazepinyl, tetrahydrobenzo[e][1,4]diazepinyl, tetrahydrobenzo[b][1,4]oxazepinyl or tetrahydrobenzo[b][1,4]thiazepinyl groups;
 and wherein   the carbon or nitrogen atom(s) of said group W being optionally substituted as defined in the general formula (I) according to  claim 1 .   
     
     
         7 . The method according to  claim 1 , wherein in compound of formula (I) W represents a fused bicyclic group of formula: 
       
         
           
           
               
               
           
         
         bonded to the nitrogen atom via positions 1, 2, 3 or 4; wherein 
         A represents a 5- to 7-membered heterocycle comprising from one to three heteroatoms chosen from O, S and N; 
         the carbon atom(s) of A being optionally substituted with one or more groups chosen from a hydrogen atom and a C 1 -C 6 -alkyl or an oxo group; or 
         the nitrogen atom(s) of A being optionally substituted with R 6  when the nitrogen is adjacent to a carbon atom substituted with an oxo group, or with R 7  in the other cases; wherein
 R 6  represents a hydrogen atom; and 
 R 7  represents a hydrogen atom or a C 1 -C 6 -alkyl group. 
 
       
     
     
         8 . The method according to  claim 1 , wherein in compound of formula (I) W is chosen from indolyl, benzimidazolyl, tetrahydroquinolyl, quinolyl or benzothiazolyl. 
     
     
         9 . A method for treating depression in a patient comprising administering to said patient a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof: 
       
         
           
           
               
               
           
         
         wherein: 
         n is equal to 0, 1, 2 or 3; 
         the pyrrolopyridine nucleus is a pyrrolo[3,2-b]pyridine group, a pyrrolo[3,2-c]pyridine group, a pyrrolo[2,3-c]pyridine group or a pyrrolo[2,3-b]pyridine group; 
         X is chosen from a halogen atom and a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, C 1 -C 6 -alkoxyl, C 1 -C 6 -fluoroalkoxyl, cyano, C(O)NR 1 R 2 , nitro, NR 1 R 2 , C 1 -C 6 -thioalkyl, —S(O)—C 1 -C 6 -alkyl, —S(O) 2 —C 1 -C 6 -alkyl, SO 2 NR 1 R 2 , NR 3 COR 4 , NR 3 SO 2 R 5  or aryl group, the aryl being optionally substituted with one or more substituents chosen from a halogen and a C 1 -C 6 -alkyl, C 3 -C 7 cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, C 1 -C 6 -alkoxyl, C 1 -C 6 -fluoroalkoxyl, nitro or cyano group; 
         Z 1 , Z 2 , Z 3 , Z 4  and Z 5  represent, independently of each other, a hydrogen or halogen atom or a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, C 1 -C 6 -alkoxyl, C 1 -C 6 -fluoroalkoxyl, cyano, C(O)NR 1 R 2 , nitro, NR 1 R 2 , C 1 -C 6 -thioalkyl, —S(O)—C 1 -C 6 -alkyl, —S(O) 2 —C 1 -C 6 -alkyl, SO 2 NR 1 R 2 , NR 3 COR 4 , NR 3 SO 2 R 5 , aryl-C 1 -C 6 -alkylene or aryl group, the aryl and the aryl-C 1 -C 6 -alkylene being optionally substituted with one or more substituents chosen from a halogen and a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, C 1 -C 6 -alkoxyl, C 1 -C 6 -fluoroalkoxyl, nitro or cyano group; and wherein
 R 1  and R 2  represent, independently of each other, a hydrogen atom or a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, aryl-C 1 -C 6 -alkylene or aryl group; or R 1  and R 2  together forming, with the nitrogen atom that bears them, an azetidine, pyrrolidine, piperidine, azepine, morpholine, thiomorpholine, piperazine, homopiperazine group, this group being optionally substituted with a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, aryl-C 1 -C 6 -alkylene or aryl group; 
 R 3  and R 4  represent, independently of each other, a hydrogen atom or a C 1 -C 6 -alkyl, aryl-C 1 -C 6 -alkylene or aryl group; 
 R 5  represents a C 1 -C 6 -alkyl or aryl group; and 
 
         W represents a fused bicyclic group of formula: 
       
       
         
           
           
               
               
           
         
         bonded to the nitrogen atom via positions 1, 2, 3 or 4; wherein
 A represents a 5- to 7-membered heterocycle comprising from one to three heteroatoms chosen from O, S and N;
 the carbon atom(s) of A being optionally substituted with one or more groups chosen from a hydrogen atom and a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, aryl, aryl-C 1 -C 6 -alkylene, oxo or thio group; and 
 the nitrogen atom(s) of A being optionally substituted with R 6  when the nitrogen is adjacent to a carbon atom substituted with an oxo group, or with R 7  in the other cases; wherein 
 
 R 6  represents a hydrogen atom or C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, aryl-C 1 -C 6 -alkylene or aryl group; 
 R 7  represents a hydrogen atom or a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, aryl-C 1 -C 6 -alkylene, C 1 -C 6 -alkyl-C(O)—, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene-(CO)—, C 1 -C 6 -fluoroalkyl-C(O)—, C 3 -C 7 -cycloalkyl-C(O)—, aryl-C(O)—, aryl-C 1 -C 6 -alkylene-C(O)—, C 1 -C 6 -alkyl-S(O) 2 —, C 1 -C 6 -fluoroalkyl-S(O) 2 —, C 3 -C 7 -cycloalkyl-S(O) 2 —, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene-S(O) 2 —, aryl-S(O) 2 — or aryl-C 1 -C 6 -alkylene-S(O) 2 — or aryl group; 
 
         the sulfur atom(s) of the heterocycle A possibly being in oxidized form; 
         the nitrogen atom(s) of the heterocycle A possibly being in oxidized form; and 
         the nitrogen atom in position 4, 5, 6 or 7 of the pyrrolopyridine may be in oxidized form. 
       
     
     
         10 . The method according to  claim 9 , wherein in compound of formula (I) n is equal to 1 or 2. 
     
     
         11 . The method according to  claim 9 , wherein in compound of formula (I) the pyrrolopyridine nucleus is a pyrrolo[3,2-b]pyridine group, a pyrrolo[3,2-c]pyridine group, a pyrrolo[2,3-c]pyridine group or a pyrrolo[2,3-b]pyridine group; and
 X is chosen from a hydrogen or halogen atom and a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 1 -C 6 -fluoroalkyl, C 1 -C 6 -alkoxyl, C 1 -C 6 -fluoroalkoxyl, nitro, NR 1 R 2 , C 1 -C 6 -thioalkyl, —S(O)—C 1 -C 6 -alkyl, —S(O) 2 -C 1 -C 6 -alkyl, or aryl group; and
 wherein 
 R 1  and R 2  are hydrogen atoms. 
   
     
     
         12 . The method according to  claim 9 , wherein in compound of formula (I) the pyrrolopyridine nucleus is a pyrrolo[3,2-b]pyridine group, a pyrrolo[3,2-c]pyridine group, a pyrrolo[2,3-c]pyridine group or a pyrrolo[2,3-b]pyridine group; and
 X is chosen from a halogen atom, a C 1 -C 6 -fluoroalkyl or aryl group.   
     
     
         13 . The method according to  claim 9 , wherein in compound of formula (I) Z 1 , Z 2 , Z 3 , Z 4  and Z 5  represent, independently of each other, a hydrogen or halogen atom. 
     
     
         14 . The method according to  claim 9 , wherein in compound of formula (I) W is chosen from indolinyl, indolyl, isoindolyl, isoindolinyl, benzofuranyl, dihydrobenzofuranyl, benzothiophenyl, dihydrobenzothiophenyl, benzoxazolyl, dihydrobenzoxazolinyl, isobenzofuranyl, dihydroisobenzofuranyl, benzimidazolyl, dihydrobenzimidazolyl, indazolyl, benzothiazolyl, isobenzothiazolyl, dihydroisobenzothiazolyl, benzotriazolyl, quinolyl, dihydroquinolyl, tetrahydroquinolyl, isoquinolyl, dihydroisoquinolyl, tetrahydroisoquinolyl, benzoxazinyl, dihydrobenzoxazinyl, benzothiazinyl, dihydrobenzothiazinyl, cinnolinyl, quinazolinyl, dihydroquinazolinyl, tetrahydroquinazolinyl, quinoxalinyl, dihydroquinoxalinyl, tetrahydroquinoxalinyl, phthalazinyl, dihydrophthalazinyl, tetrahydrophthalazinyl, tetrahydrobenz[b]azepinyl, tetrahydrobenz[c]azepinyl, tetrahydrobenz[d]azepinyl, tetrahydrobenzo[b][1,4]diazepinyl, tetrahydrobenzo[e][1,4]diazepinyl, tetrahydrobenzo[b][1,4]oxazepinyl or tetrahydrobenzo[b][1,4]thiazepinyl groups;
 and wherein   the carbon or nitrogen atom(s) of said group W being optionally substituted as defined in the general formula (I) according to  claim 1 .   
     
     
         15 . The method according to  claim 9 , wherein in compound of formula (I) W represents a fused bicyclic group of formula: 
       
         
           
           
               
               
           
         
         bonded to the nitrogen atom via positions 1, 2, 3 or 4; wherein 
         A represents a 5- to 7-membered heterocycle comprising from one to three heteroatoms chosen from O, S and N; 
         the carbon atom(s) of A being optionally substituted with one or more groups chosen from a hydrogen atom and a C 1 -C 6 -alkyl or an oxo group; or 
         the nitrogen atom(s) of A being optionally substituted with R 6  when the nitrogen is adjacent to a carbon atom substituted with an oxo group, or with R 7  in the other cases; wherein
 R 6  represents a hydrogen atom; and 
 R 7  represents a hydrogen atom or a C 1 -C 6 -alkyl group. 
 
       
     
     
         16 . The method according to  claim 9 , wherein in compound of formula (I) W is chosen from indolyl, benzimidazolyl, tetrahydroquinolyl, quinolyl or benzothiazolyl. 
     
     
         17 . A method for treating diabetes in a patient comprising administering to said patient a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof: 
       
         
           
           
               
               
           
         
         wherein: 
         n is equal to 0, 1, 2 or 3; 
         the pyrrolopyridine nucleus is a pyrrolo[3,2-b]pyridine group, a pyrrolo[3,2-c]pyridine group, a pyrrolo[2,3-c]pyridine group or a pyrrolo[2,3-b]pyridine group; 
         X is chosen from a halogen atom and a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, C 1 -C 6 -alkoxyl, C 1 -C 6 -fluoroalkoxyl, cyano, C(O)NR 1 R 2 , nitro, NR 1 R 2 , C 1 -C 6 -thioalkyl, —S(O)—C 1 -C 6 -alkyl, —S(O) 2 —C 1 -C 6 -alkyl, SO 2 NR 1 R 2 , NR 3 COR 4 , NR 3 SO 2 R 5  or aryl group, the aryl being optionally substituted with one or more substituents chosen from a halogen and a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 C 3 -alkylene, C 1 -C 6 -fluoroalkyl, C 1 -C 6 -alkoxyl, C 1 -C 6 -fluoroalkoxyl, nitro or cyano group; 
         Z 1 , Z 2 , Z 3 , Z 4  and Z 5  represent, independently of each other, a hydrogen or halogen atom or a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, C 1 -C 6 -alkoxyl, C 1 -C 6 -fluoroalkoxyl, cyano, C(O)NR 1 R 2 , nitro, NR 1 R 2 , C 1 -C 6 -thioalkyl, —S(O)—C 1 -C 6 -alkyl, —S(O) 2 —C 1 -C 6 -alkyl, SO 2 NR 1 R 2 , NR 3 COR 4 , NR 3 SO 2 R 5,  aryl-C 1 -C 6 -alkylene or aryl group, the aryl and the aryl-C 1 -C 6 -alkylene being optionally substituted with one or more substituents chosen from a halogen and a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, C 1 -C 6 -alkoxyl, C 1 -C 6 -fluoroalkoxyl, nitro or cyano group; and wherein
 R 1  and R 2  represent, independently of each other, a hydrogen atom or a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, aryl-C 1 -C 6 -alkylene or aryl group; or R 1  and R 2  together forming, with the nitrogen atom that bears them, an azetidine, pyrrolidine, piperidine, azepine, morpholine, thiomorpholine, piperazine, homopiperazine group, this group being optionally substituted with a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, aryl-C 1 -C 6 -alkylene or aryl group; 
 R 3  and R 4  represent, independently of each other, a hydrogen atom or a C 1 -C 6 -alkyl, aryl-C 1 -C 6 -alkylene or aryl group; 
 R 5  represents a C 1 -C 6 -alkyl or aryl group; and 
 
         W represents a fused bicyclic group of formula: 
       
       
         
           
           
               
               
           
         
         bonded to the nitrogen atom via positions 1, 2, 3 or 4; wherein
 A represents a 5- to 7-membered heterocycle comprising from one to three heteroatoms chosen from O, S and N;
 the carbon atom(s) of A being optionally substituted with one or more groups chosen from a hydrogen atom and a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, aryl, aryl-C 1 -C 6 -alkylene, oxo or thio group; and 
 the nitrogen atom(s) of A being optionally substituted with R 6  when the nitrogen is adjacent to a carbon atom substituted with an oxo group, or with R 7  in the other cases; wherein 
 
 R 6  represents a hydrogen atom or C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, aryl-C 1 -C 6 -alkylene or aryl group; 
 R 7  represents a hydrogen atom or a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene, C 1 -C 6 -fluoroalkyl, aryl-C 1 -C 6 -alkylene, C 1 -C 6 -alkyl-C(O)—, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene-(CO)—, C 1 -C 6 -fluoroalkyl-C(O)—, C 3 -C 7 -cycloalkyl-C(O)—, aryl-C(O)—, aryl-C 1 -C 6 -alkylene-C(O)—, C 1 -C 6 -alkyl-S(O) 2 —, C 1 -C 6 -fluoroalkyl-S(O) 2 —, C 3 -C 7 -cycloalkyl-S(O) 2 —, C 3 -C 7 -cycloalkyl-C 1 -C 3 -alkylene-S(O) 2 —, aryl-S(O) 2 — or aryl-C 1 -C 6 -alkylene-S(O) 2 — or aryl group; 
 
         the sulfur atom(s) of the heterocycle A possibly being in oxidized form; 
         the nitrogen atom(s) of the heterocycle A possibly being in oxidized form; and 
         the nitrogen atom in position 4, 5, 6 or 7 of the pyrrolopyridine may be in oxidized form. 
       
     
     
         18 . The method according to  claim 17 , wherein in compound of formula (I) n is equal to 1 or 2. 
     
     
         19 . The method according to  claim 17 , wherein in compound of formula (I) the pyrrolopyridine nucleus is a pyrrolo[3,2-b]pyridine group, a pyrrolo[3,2-c]pyridine group, a pyrrolo[2,3-c]pyridine group or a pyrrolo[2,3-b]pyridine group; and
 X is chosen from a hydrogen or halogen atom and a C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 1 -C 6 -fluoroalkyl, C 1 -C 6 -alkoxyl, C 1 -C 6 -fluoroalkoxyl, nitro, NR 1 R 2 , C 1 -C 6 -thioalkyl, —S(O)—C 1 -C 6 -alkyl, —S(O) 2 —C 1 -C 6 -alkyl, or aryl group; and
 wherein 
 R 1  and R 2  are hydrogen atoms. 
   
     
     
         20 . The method according to  claim 17 , wherein in compound of formula (I) the pyrrolopyridine nucleus is a pyrrolo[3,2-b]pyridine group, a pyrrolo[3,2-c]pyridine group, a pyrrolo[2,3-c]pyridine group or a pyrrolo[2,3-b]pyridine group; and
 X is chosen from a halogen atom, a C 1 -C 6 -fluoroalkyl or aryl group.   
     
     
         21 . The method according to  claim 17 , wherein in compound of formula (I) Z 1 , Z 2 , Z 3 , Z 4  and Z 5  represent, independently of each other, a hydrogen or halogen atom. 
     
     
         22 . The method according to  claim 17 , wherein in compound of formula (I) W is chosen from indolinyl, indolyl, isoindolyl, isoindolinyl, benzofuranyl, dihydrobenzofuranyl, benzothiophenyl, dihydrobenzothiophenyl, benzoxazolyl, dihydrobenzoxazolinyl, isobenzofuranyl, dihydroisobenzofuranyl, benzimidazolyl, dihydrobenzimidazolyl, indazolyl, benzothiazolyl, isobenzothiazolyl, dihydroisobenzothiazolyl, benzotriazolyl, quinolyl, dihydroquinolyl, tetrahydroquinolyl, isoquinolyl, dihydroisoquinolyl, tetrahydroisoquinolyl, benzoxazinyl, dihydrobenzoxazinyl, benzothiazinyl, dihydrobenzothiazinyl, cinnolinyl, quinazolinyl, dihydroquinazolinyl, tetrahydroquinazolinyl, quinoxalinyl, dihydroquinoxalinyl, tetrahydroquinoxalinyl, phthalazinyl, dihydrophthalazinyl, tetrahydrophthalazinyl, tetrahydrobenz[b]azepinyl, tetrahydrobenz[b]azepinyl, tetrahydrobenz[b]azepinyl, tetrahydrobenzo[b][1,4]diazepinyl, tetrahydrobenzo[e][1,4]diazepinyl, tetrahydrobenzo[b][1,4]oxazepinyl or tetrahydrobenzo[b][1,4]thiazepinyl groups; and wherein the carbon or nitrogen atom(s) of said group W being optionally substituted as defined in the general formula (I) according to  claim 1 . 
     
     
         23 . The method according to  claim 17 , wherein in compound of formula (I) W represents a fused bicyclic group of formula: 
       
         
           
           
               
               
           
         
         bonded to the nitrogen atom via positions 1, 2, 3 or 4; wherein 
         A represents a 5- to 7-membered heterocycle comprising from one to three heteroatoms chosen from O, S and N; 
         the carbon atom(s) of A being optionally substituted with one or more groups chosen from a hydrogen atom and a C 1 -C 6 -alkyl or an oxo group; or 
         the nitrogen atom(s) of A being optionally substituted with R 6  when the nitrogen is adjacent to a carbon atom substituted with an oxo group, or with R 7  in the other cases; wherein
 R 6  represents a hydrogen atom; and 
 R 7  represents a hydrogen atom or a C 1 -C 6 -alkyl group. 
 
       
     
     
         24 . The method according to  claim 17 , wherein in compound of formula (I) W is chosen from indolyl, benzimidazolyl, tetrahydroquinolyl, quinolyl or benzothiazolyl.