Antimicrobial compounds

Abstract

The invention relates to compositions comprising a compound based on the general formula (I) R 1 -Arg-R 2 —NH—CH(R 3 )—CH 2 —NH—R 4   (I) The composition may be used to eliminate and/or reduce microorganisms such as bacteria, viruses, fungi and protozoa.

1 . A method for treating viral, fungal, or a mixture of viral and bacterial infection or disease, the method comprising administering an effective amount of a medicament comprising a compound having the formula (I)
   R 1 -Arg-R 2 —NH—CH(R 3 )—CH 2 —NH—R 4      wherein   R 1  is benzyloxycarbonyl or 3-phenylpropionyl,   and   R 2  is an amino acid residue selected from the group consisting of Val, Ile, Leu and Phe,   and   R 3  is selected from the group consisting of isopropyl, isobutyl, sec.butyl, benzyl, 4-hydroxybenzyl and phenyl   and   R 4  is an acyl residue comprising a phenyl ring.   
   
   
       2 . A method according to  claim 1 , wherein the a compound is selected from the group consisting of: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
   
   
       3 . A method according to  claim 1 , wherein the virus is selected from the group consisting of polio viruses, Echoviruses, Herpesviridae, H5N1, SARS, HIV, adenoviruses, coxsackieviruses, hepatite A, B and C and rhinoviruses. 
   
   
       4 . A method according to  claim 1 , wherein said fungus is selected from the group consisting of candida, dermatophytes, and mould. 
   
   
       5 . A method according to  claim 1 , wherein said bacteria is selected from the group consisting of Staphylococci, Pneumococci, Streptococci, and  Listeria.    
   
   
       6 . A method according to  claim 1 , wherein the medicament further comprises one or more antimicrobial agents. 
   
   
       7 . A method according to  claim 1 , wherein the therapeutic agents are selected from the group consisting of penicillins, cephalosporins, carbacephems, cephamycins, carbapenems, monobactams, aminoglycosides, glycopeptides, quinolones, tetracyclines, macrolides, fluoroquinolones, antiseptic agents including iodine, silver, copper, chlorhexidine, polyhexanide and other biguanides, docosanol, acetic acid, and hydrogen peroxide. 
   
   
       8 . A method according to  claim 1 , wherein the medicament is in the form of granules, powders, tablets, coated tablets, (micro) capsules, suppositories, syrups, emulsions, gels, ointments, suspensions, creams, aerosols, drops or injectable solution in ampule form.