US2010247539A1PendingUtilityA1

Antibodies that Inhibit Transport Activity of Peptide Transporters

41
Assignee: CHUGAI PHARMACEUTICAL CO LTDPriority: Mar 28, 2003Filed: Feb 25, 2010Published: Sep 30, 2010
Est. expiryMar 28, 2023(expired)· nominal 20-yr term from priority
Inventors:Tatsuhiko KodamaTakao HamakuboRyoichi SaitohYoshiki Yamada
A61P 35/00A61K 2039/505C07K 16/30C07K 16/18C07K 2317/76A61P 43/00
41
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

The present inventors discovered that the PepT-binding antibodies have the ability to inhibit the transport activity of peptide transporters, as a result of dedicated research. These antibodies may be utilized as cell growth inhibitors, for example, for treating and preventing cancer.

Claims

exact text as granted — not AI-modified
1 . An isolated antibody, or fragment thereof, that
 (a) binds to a peptide transporter and   (b) inhibits peptide uptake into a cell expressing the peptide transporter,   wherein the antibody is a monoclonal or genetically engineered recombinant antibody, or antigen-binding fragment thereof.   
     
     
         2 . The antibody or fragment thereof of  claim 1 , wherein the peptide transporter is a proton motive force (PMF) dependent transporter. 
     
     
         3 . The antibody or fragment thereof of  claim 1 , wherein the peptide transporter is PepT1. 
     
     
         4 . The antibody or fragment thereof of  claim 1 , wherein the peptide transporter is PepT2. 
     
     
         5 . The antibody or fragment thereof of  claim 1 , wherein the antibody is monoclonal. 
     
     
         6 . The antibody or fragment thereof of  claim 1 , wherein the antibody or fragment thereof is recombinant. 
     
     
         7 . The antibody or fragment thereof of  claim 1 , wherein the antibody is humanized or chimeric. 
     
     
         8 . The antibody or fragment thereof of  claim 1 , wherein the antibody is bispecific. 
     
     
         9 . An isolated antibody, or fragment thereof, that
 (a) binds to a peptide transporter and   (b) inhibits the growth of a cell,   wherein the antibody is a monoclonal or genetically engineered recombinant antibody, or antigen-binding fragment thereof.   
     
     
         10 . The antibody or fragment thereof of  claim 9 , wherein the peptide transporter is a PMF dependent transporter. 
     
     
         11 . The antibody or fragment thereof of  claim 9 , wherein the peptide transporter is PepT1. 
     
     
         12 . The antibody or fragment thereof of  claim 9 , wherein the peptide transporter is PepT2. 
     
     
         13 . The antibody or fragment thereof of  claim 9 , wherein the cell is a cancer cell. 
     
     
         14 . The antibody or fragment thereof of  claim 9 , wherein the cell is a pancreatic cancer cell. 
     
     
         15 . The antibody or fragment thereof of  claim 9 , wherein the antibody is monoclonal. 
     
     
         16 . The antibody or fragment thereof of  claim 9 , wherein the antibody or fragment thereof is recombinant. 
     
     
         17 . The antibody or fragment thereof of  claim 9 , wherein the antibody is humanized or chimeric. 
     
     
         18 . The antibody or fragment thereof of  claim 9 , wherein the antibody is bispecific. 
     
     
         19 . A diabody that binds to a peptide transporter and inhibits peptide uptake into a cell expressing the peptide transporter. 
     
     
         20 . The diabody of  claim 19 , wherein the peptide transporter is a PMF dependent transporter. 
     
     
         21 . The diabody of  claim 19 , wherein the peptide transporter is PepT1. 
     
     
         22 . The diabody of  claim 9 , wherein the peptide transporter is PepT2. 
     
     
         23 . A composition comprising the antibody or fragment thereof of  claim 1  and a pharmaceutically acceptable carrier, wherein the antibody or fragment thereof inhibits the growth of a cell. 
     
     
         24 . The composition of  claim 23 , wherein the cell is a cancer cell. 
     
     
         25 . The composition of  claim 23 , wherein the cell is a pancreatic cancer cell. 
     
     
         26 . A composition comprising the antibody or fragment thereof of  claim 9  and a pharmaceutically acceptable carrier, wherein the antibody or fragment thereof inhibits the growth of a cell. 
     
     
         27 . The composition of  claim 26 , wherein the cell is a cancer cell. 
     
     
         28 . The composition of  claim 26 , wherein the cell is a pancreatic cancer cell.

Join the waitlist — get patent alerts

Track US2010247539A1 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.