Substituted 2-mercaptoquinoline-3-carboxamides as kcnq2/3 modulators

Abstract

The invention relates to substituted 2-mercaptoquinoline-3-carboxamides, methods for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.

1 . A substituted 2-mercaptoquinoline-3-carboxamide having the general formula (1): 
     
       
         
         
             
             
         
       
     
     wherein
 R 0  stands for C 1-10  alkyl or C 2-10  heteroalkyl, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted; C 3-10  cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted; aryl or heteroaryl, each unsubstituted or mono- or polysubstituted; C 1-8  alkyl- or C 2-8  heteroalkyl-bridged C 3-10  cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted, wherein the alkyl or heteroalkyl chain can in each case be branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or C 1-8  alkyl- or C 2-8  heteroalkyl-bridged aryl or heteroaryl, each unsubstituted or mono- or polysubstituted, wherein the alkyl or heteroalkyl chain can in each case be branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; 
 R 1 , R 2 , R 3 , R 4  each denote independently of one another H; F; Cl; Br; I; NO 2 ; CF 3 ; CN; R 0 ; C(═O)H; C(═O)R 0 ; CO 2 H; C(═O)OR 0 ; CONH 2 ; C(═O)NHR 0 ; C(═O)N(R 0 ) 2 ; OH; OR 0 ; O—C(═O)—R 0 ; O—C(═O)—O—R 0 ; O—(C═O)—NH—R 0 ; O—C(═O)—N(R 0 ) 2 ; O—S(═O) 2 —R 0 ; O—S(═O) 2 OH; O—S(═O) 2 OR 0 ; O—S(═O) 2 NH 2 ; O—S(═O) 2 NHR 0 ; O—S(═O) 2 N(R 0 ) 2 ; NH 2 ; NH—R 0 ; N(R 0 ) 2 ; NH—C(═O)—R 0 ; NH—C(═O)—O—R 0 ; NH—C(═O)—NH 2 ; NH—C(═O)—NH—R 0 ; NH—C(═O)—N(R 0 ) 2 ; NR 0 —C(═O)—R 0 ; NR 0 —C(═O)—O—R 0 ; NR 0 —C(═O)—NH 2 ; NR 0 —C(═O)—NH—R 0 ; NR 0 —C(═O)—N(R 0 ) 2 ; NH—S(═O) 2 OH; NH—S(═O) 2 R 0 ; NH—S(═O) 2 OR 0 ; NH—S(═O) 2 NH 2 ; NH—S(═O) 2 NHR 0 ; NH—S(═O) 2 N(R 0 ) 2 ; NR 0 —S(═O) 2 OH; NR 0 —S(═O) 2 R 0 ; NR 0 —S(═O) 2 OR 0 ; NR 0 —S(═O) 2 NH 2 ; NR 0 —S(═O) 2 NHR 0 ; NR 0 —S(═O) 2 N(R 0 ) 2 ; SH; SR 0 ; S(═O)R 0 ; S(═O) 2 R 0 ; S(═O) 2 OH; S(═O) 2 OR 0 ; S(═O) 2 NH 2 ; S(═O) 2 NHR 0 ; or S(═O) 2 N(R 0 ) 2 ; 
 R 5  stands for H; F; Cl; Br; I; NO 2 ; CF 3 ; CN; R 0 ; C(═O)H; C(═O)R 0 ; CO 2 H; C(═O)OR 0 ; CONH 2 ; C(═O)NHR 0 ; C(═O)N(R 0 ) 2 ; OR 0 ; O—C(═O)—R 0 ; O—C(═O)—O—R 0 ; O—(C═O)—NH—R 0 ; O—C(═O)—N(R 0 ) 2 ; O—S(═O) 2 —R 0 ; O—S(═O) 2 OH; O—S(═O) 2 OR 0 ; O—S(═O) 2 NH 2 ; O—S(═O) 2 NHR 0 ; O—S(═O) 2 N(R 0 ) 2 ; NH 2 ; NH—R 0 ; N(R 0 ) 2 ; NH—C(═O)—R 0 ; NH—C(═O)—O—R 0 ; NH—C(═O)—NH 2 ; NH—C(═O)—NH—R 0 ; NH—C(═O)—N(R 0 ) 2 ; NR 0 —C(═O)—R 0 ; NR 0 —C(═O)—O—R 0 ; NR 0 —C(═O)—NH 2 ; NR 0 —C(═O)—NH—R 0 ; NO—C(═O)—N(O) 2 ; NH—S(═O) 2 OH; NH—S(═O) 2 R 0 ; NH—S(═O) 2 OR 0 ; NH—S(═O) 2 NH 2 ; NH—S(═O) 2 NHR 0 ; NH—S(═O) 2 N(R) 2 ; NR 0 —S(═O) 2 OH; NR 0 —S(═O) 2 R 0 ; NR 0 —S(═O) 2 OR 0 ; NR 0 —S(═O) 2 NH 2 ; NR 0 —S(═O) 2 NHR 0 ; NR 0 —S(═O) 2 N(R 0 ) 2 ; SH; SR 0 ; S(═O)R 0 ; S(═O) 2 R 0 ; S(═O) 2 OH; S(═O) 2 OR 0 ; S(═O) 2 NH 2 ; S(═O) 2 NHR 0 ; or S(═O) 2 N(R 0 ) 2 ; 
 R 6  stands for R 0 , with the proviso that if R 0  denotes heterocyclyl, saturated or unsaturated, unsubstituted or mono- or polysubstituted, or heteroaryl, unsubstituted or mono- or polysubstituted, then of the heteroaryl or heterocyclyl is bound via a carbon atom of the heteroaryl or heterocyclyl; 
 R 7  stands for R 0 , with the proviso that if R 0  denotes heterocyclyl, saturated or unsaturated, unsubstituted or mono- or polysubstituted, or heteroaryl, unsubstituted or mono- or polysubstituted, then the heteroaryl or heterocyclyl is bound via a carbon atom of the heteroaryl or heterocyclyl; 
 wherein “substituted” in the case of substitution on alkyl, heteroalkyl, heterocyclyl and cycloalkyl stands for the substitution of one or more hydrogen atoms, each independently of one another, with F; Cl; Br; I; CN; CF 3 ; ═O; ═NH; ═C(NH 2 ) 2 ; NO 2 ; R 0 ; C(═O)H; C(═O)R 0 ; CO 2 H; C(═O)OR 0 ; CONH 2 ; C(═O)NHR 0 ; C(═O)N(R 0 ) 2 ; OH; OR 0 ; —O—(C 1-8  alkyl)-O—; O—C(═O)—R 0 ; O—C(═O)—O—R 0 ; O—(C═O)—NH—R 0 ; O—C(═O)—N(R 0 ) 2 ; O—S(═O) 2 —R 0 ; O—S(═O) 2 OH; O—S(═O) 2 OR 0 ; O—S(═O) 2 NH 2 ; O—S(═O) 2 NHR 0 ; O—S(═O) 2 N(R 0 ) 2 ; NH 2 ; NH—R 0 ; N(R 0 ) 2 ; NH—C(═O)—R 0 ; NH—C(═O)—O—R 0 ; NH—C(═O)—NH 2 ; NH—C(═O)—NH—R 0 ; NH—C(═O)—N(R 0 ) 2 ; NR 0 —C(═O)—R 0 ; NR 0 —C(═O)—O—R 0 ; NR 0 —C(═O)—NH 2 ; NR 0 —C(═O)—NH—R 0 ; NR 0 —C(═O)—N(R 0 ) 2 ; NH—S(═O) 2 OH; NH—S(═O) 2 R 0 ; NH—S(═O) 2 OR 0 ; NH—S(═O) 2 NH 2 ; NH—S(═O) 2 NHR 0 ; NH—S(═O) 2 N(R 0 ) 2 ; NR 0 —S(═O) 2 OH; NR 0 —S(═O) 2 R 0 ; NR 0 —S(═O) 2 OR 0 ; NR 0 —S(═O) 2 NH 2 ; NR 0 —S(═O) 2 NHR 0 ; NR 0 —S(═O) 2 N(R 0 ) 2 ; SH; SR 0 ; S(═O)R 0 ; S(═O) 2 R 0 ; S(═O) 2 H; S(═O) 2 OH; S(═O) 2 OR 0 ; S(═O) 2 NH 2 ; S(═O) 2 NHR 0 ; or S(═O) 2 N(R) 2 ; 
 wherein “substituted” in the case of substitution on aryl and heteroaryl stands for the substitution of one or more hydrogen atoms, each independently of one another, with F; Cl; Br; I; NO 2 ; CF 3 ; CN; R 0 ; C(═O)H; C(═O)R 0 ; CO 2 H; C(═O)OR 0 ; CONH 2 ; C(═O)NHR 0 ; C(═O)N(R 0 ) 2 ; OH; OR 0 ; —O—(C 1-8  alkyl)-O—; O—C(═O)—R 0 ; O—C(═O)—O—R 0 ; O—(C═O)—NH—R 0 ; O—C(═O)—N(R 0 ) 2 ; O—S(═O) 2 —R 0 ; O—S(═O) 2 OH; O—S(═O) 2 OR 0 ; O—S(═O) 2 NH 2 ; O—S(═O) 2 NHR 0 ; O—S(═O) 2 N(R 0 ) 2 ; NH 2 ; NH—R 0 ; N(R 0 ) 2 ; NH—C(═O)—R 0 ; NH—C(═O)—O—R 0 ; NH—C(═O)—NH 2 ; NH—C(═O)—NH—R 0 ; NH—C(═O)—N(R 0 ) 2 ; NR 0 —C(═O)—R 0 ; NR 0 —C(═O)—O—R 0 ; NR 0 —C(═O)—NH 2 ; NR 0 —C(═O)—NH—R 0 ; NR 0 —C(═O)—N(R 0 ) 2 ; NH—S(═O) 2 OH; NH—S(═O) 2 R 0 ; NH—S(═O) 2 OR 0 ; NH—S(═O) 2 NH 2 ; NH—S(═O) 2 NHR 0 ; NH—S(═O) 2 N(R 0 ) 2 ; NR 0 —S(═O) 2 OH; NR 0 —S(═O) 2 R 0 ; NR 0 —S(═O) 2 OR 0 ; NR 0 —S(═O) 2 NH 2 ; NR 0 —S(═O) 2 NHR 0 ; NR 0 —S(═O) 2 N(R 0 ) 2 ; SH; SR 0 ; S(═O)R 0 ; S(═O) 2 R 0 ; S(═O) 2 OH; S(═O) 2 OR 0 ; S(═O) 2 NH 2 ; S(═O) 2 NHR 0 ; or S(═O) 2 N(R 0 ) 2 ; 
 with the exception of the following compound: 
 N-benzyl-2-(3-chloro-2-hydroxypropylthio)-4-(2,4-dichlorophenyl)quinoline-3-carboxamide; 
 said substituted 2-mercaptoquinoline-3-carboxamide being in the form of a free compound or a salt of physiologically compatible acids or bases. 
 
   
   
       2 . Substituted carboxamide according to  claim 1 , wherein
 R 1 , R 2 , R 3  and R 4  are each selected independently of one another from the group consisting of H; F; Cl; Br; I; NO 2 ; CF 3 ; CN; R 0 ; C(═O)(R 0  or H); C(═O)O(R 0  or H); C(═O)N(R 0  or H) 2 ; OH; OR 0 ; O—(C 1-8  alkyl)-OH; O—(C 1-8  alkyl)-O—C 1-8  alkyl; OCF 3 ; O—C(═O)—R 0 ; N(R 0  or H) 2 ; N(R 0  or H)—C(═O)—R 0 ; N(R 0  or H)—C(═O)—N(R 0  or H) 2 ; SH; SCF 3 ; SR 0 ; S(═O) 2 R 0 ; S(═O) 2 O(R 0  or H) and S(═O) 2 —N(R 0  or H) 2 ;   R 5  is selected from the group consisting of H; F; Cl; Br; I; NO 2 ; CF 3 ; CN; C(═O)(R 0  or H); C(═O)O(R 0  or H); C(═O)N(R 0  or H) 2 ; N(R 0  or H) 2 ; N(R 0  or H)—C(═O)—R 0 ; N(R 0  or H)—C(═O)—N(R 0  or H) 2 ; SH; SCF 3 ; SR 0 ; S(═O) 2 R 0 ; S(═O) 2 O(R 0  or H); and S(═O) 2 —N(R 0  or H) 2 ;   R 6  stands for   C 1-10  alkyl or C 2-10  heteroalkyl, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CF 3 , CN, OH, ═O, C(═O)—OH, OCF 3 , NH 2 , S(═O) 2 OH, SH, SCF 3 , C 1-8  alkyl, O—C 1-8  alkyl, S—C 1-8  alkyl, NH—C 1-8  alkyl, N(C 1-8  alkyl) 2 , C 3-10  cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O—C 1-8  alkyl, OH and OCF 3 , and wherein the aforementioned C 3-10  cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C 1-8  alkyl, OH, ═O, O—C 1-8  alkyl, OCF 3 , NH 2 , NH—C 1-8  alkyl and N(C 1-8  alkyl) 2 ,   C 3-10  cycloalkyl or heterocyclyl or C 1-8  alkyl- or C 2-8  heteroalkyl-bridged C 3-10  cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, ═O, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-8  alkyl), N(C 1-8  alkyl) 2 , SH, S—C 1-8  alkyl, SCF 3 , S(═O) 2 OH, benzyl, phenyl, pyridyl and thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-8  alkyl), N(C 1-8  alkyl) 2 , SH, S—C 1-8  alkyl, SCF 3  and S(═O) 2 OH;   and wherein optionally the alkyl chain or heteroalkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CF 3 , CN, OH, ═O, C(═O)—OH, OCF 3 , NH 2 , S(═O) 2 OH, SH, SCF 3 , C 1-8  alkyl, O—C 1-8  alkyl, S—C 1-8  alkyl, NH—C 1-8  alkyl, N(C 1-8  alkyl) 2 , C 3-10  cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O—C 1-8  alkyl, OH and OCF 3 , and wherein the aforementioned C 3-10  cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C 1-8  alkyl, OH, ═O, O—C 1-8  alkyl, OCF 3 , NH 2 , NH—C 1-8  alkyl and N(C 1-8  alkyl) 2 ; or   aryl or heteroaryl or C 1-73  alkyl- or C 2-8  heteroalkyl-bridged aryl or heteroaryl, each unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-8  alkyl), N(C 1-8  alkyl) 2 , SH, S—C 1-8  alkyl, SCF 3 , S(═O) 2 OH, benzyl, phenyl, pyridyl and thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-8  alkyl), N(C 1-8  alkyl) 2 , SH, S—C 1-8  alkyl, SCF 3  and S(═O) 2 OH;   and wherein optionally the alkyl chain or heteroalkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CF 3 , CN, OH, ═O, C(═O)—OH, OCF 3 , NH 2 , S(═O) 2 OH, SH, SCF 3 , C 1-8  alkyl, O—C 1-8  alkyl, S—C 1-8  alkyl, NH—C 1-8  alkyl, N(C 1-8  alkyl) 2 , C 3-10  cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O—C 1-8  alkyl, OH and OCF 3 , and wherein the aforementioned C 3-10  cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C 1-8  alkyl, OH, ═O, O—C 1-8  alkyl, OCF 3 , NH 2 , NH—C 1-8  alkyl and N(C 1-8  alkyl) 2 ; and   R 7  stands for   C 1-10  alkyl or C 2-10  heteroalkyl, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CF 3 , CN, OH, ═O, C(═O)—OH, OCF 3 , NH 2 , S(═O) 2 OH, SH, SCF 3 , C 1-8  alkyl, O—C 1-8  alkyl, S—C 1-8  alkyl, NH—C 1-8  alkyl, N(C 1-8  alkyl) 2 , C 3-10  cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O—C 1-8  alkyl, OH and OCF 3 , and wherein the aforementioned C 3-10  cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C 1-8  alkyl, OH, ═O, O—C 1-8  alkyl, OCF 3 , NH 2 , NH—C 1-8  alkyl and N(C 1-8  alkyl) 2 ;   C 3-10  cycloalkyl or heterocyclyl or C 1-8  alkyl- or C 2-8  heteroalkyl-bridged C 3-10  cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, ═O, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-8  alkyl), N(C 1-8  alkyl) 2 , SH, S—C 1-8  alkyl, SCF 3 , S(═O) 2 OH, benzyl, phenyl, pyridyl, and thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-8  alkyl), N(C 1-8  alkyl) 2 , SH, S—C 1-8  alkyl, SCF 3 ; S(═O) 2 OH;   and wherein optionally the alkyl chain or heteroalkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CF 3 , CN, OH, ═O, C(═O)—OH, OCF 3 , NH 2 , S(═O) 2 OH, SH, SCF 3 , C 1-8  alkyl, O—C 1-8  alkyl, S—C 1-8  alkyl, NH—C 1-8  alkyl, N(C 1-8  alkyl) 2 , C 3-10  cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O—C 1-8  alkyl, OH and OCF 3 , and wherein the aforementioned C 3-10  cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C 1-8  alkyl, OH, ═O, O—C 1-8  alkyl, OCF 3 , NH 2 , NH—C 1-8  alkyl and N(C 1-8  alkyl) 2 ; or   aryl or heteroaryl or C 1-8  alkyl- or C 2-8  heteroalkyl-bridged aryl or heteroaryl, each unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-8  alkyl), N(C 1-8  alkyl) 2 , SH, S—C 1-8  alkyl, SCF 3 , S(═O) 2 OH, benzyl, phenyl, pyridyl, and thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-8  alkyl), N(C 1-8  alkyl) 2 , SH, S—C 1-8  alkyl, SCF 3  and S(═O) 2 OH;   and wherein optionally the alkyl chain or heteroalkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CF 3 , CN, OH, ═O, C(═O)—OH, OCF 3 , NH 2 , S(═O) 2 OH, SH, SCF 3 , C 1-8  alkyl, O—C 1-8  alkyl, S—C 1-8  alkyl, NH—C 1-8  alkyl, N(C 1-8  alkyl) 2 , C 3-10  cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, O—C 1-8  alkyl, OH and OCF 3 ; and wherein the aforementioned C 3-10  cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, C 1-8  alkyl, OH, ═O, O—C 1-8  alkyl, OCF 3 , NH 2 , NH—C 1-8  alkyl and N(C 1-8  alkyl) 2 .   
   
   
       3 . Substituted carboxamide according to  claim 1 , wherein
 R 1 , R 2 , R 3  and R 4  are each selected independently of one another from the group consisting of H; F; Cl; Br; I; NO 2 ; CF 3 ; CN; R 0 ; C(═O)(R 0  or H); C(═O)O(R 0  or H); C(═O)N(R 0  or H) 2 ; OH; OR 0 ; O—(C 1-8  alkyl)-OH; O—(C 1-8  alkyl)-O—C 1-8  alkyl; OCF 3 ; O—C(═O)—R 0 ; N(R 0  or H) 2 ; N(R 0  or H)—C(═O)—R 0 ; N(R 0  or H)—C(═O)—N(R 0  or H) 2 ; SH; SCF 3 ; SR 0 ; S(═O) 2 R 0 ; S(═O) 2 O(R 0  or H); and S(═O) 2 —N(R 0  or H) 2 ;   and R 5  is selected from the group consisting of H; F; Cl; Br; I; NO 2 ; CF 3 ; CN; R 0 ; C(═O)(R 0  or H); C(═O)O(R 0  or H); C(═O)N(R 0  or H) 2 ; OR 0 ; —O—(C 1-8  alkyl)-OH; O—(C 1-8  alkyl)-O—C 1-8  alkyl; OCF 3 ; O—C(═O)-e; N(R 0  or H) 2 ; N(R 0  or H)—C(═O)—R 0 ; N(R 0  or H)—C(═O)—N(R 0  or H) 2 ; SH; SCF 3 ; SR 0 ; S(═O) 2 R 0 ; S(═O) 2 O(R 0  or H); and S(═O) 2 —N(R 0  or H) 2 .   
   
   
       4 . Substituted carboxamide according to  claim 1 , wherein,
 R 1 , R 2 , R 3  and R 4  are each selected independently of one another from the group consisting of H; F; Cl; Br; I; NO 2 ; CF 3 ; CN; C(═O)H; C(═O)—OH; C(═O)—NH 2 ; C 1-8  alkyl, O—C 1-8  alkyl, C(═O)C 1-8  alkyl, C(═O)O—C 1-8  alkyl, O—C(═O)—C 1-8  alkyl, C(═O)NH—C 1-8  alkyl, C(═O)N(C 1-8  alkyl) 2 , NH—C 1-8  alkyl, N(C 1-8  alkyl) 2 , NH—C(═O)C 1-8  alkyl, N(C 1-8  alkyl)-C(═O)C 1-8  alkyl, S—C 1-8  alkyl, S(═O) 2 C 1-8  alkyl, and S(═O) 2 O—C 1-8  alkyl, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, O-methyl and OH; OH; OCF 3 ; SH; SCF 3 ; S(═O) 2 OH; NH 2 ; C 3-10  cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted; benzyl, phenyl, pyridyl or thienyl, each unsubstituted or mono-, di- or trisubstituted with one, two or three substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , NH 2 , CN, C 1-8  alkyl, O—C 1-8  alkyl, CF 3 , OH, OCF 3 , C(═O)—OH, SCF 3  and S(═O) 2 OH;   and R 5  is selected from the group consisting of H; F; Cl; Br; I; NO 2 ; CF 3 ; CN; C(═O)H; C(═O)—OH; C(═O)—NH 2 ; C 1-8  alkyl, O—C 1-8  alkyl, C(═O)C 1-8  alkyl, C(═O)O—C 1-8  alkyl, O—C(═O)—C 1-8  alkyl, C(═O)NH—C 1-8  alkyl, C(═O)N(C 1-8  alkyl) 2 , NH—C 1-8  alkyl, N(C 1-8  alkyl) 2 , NH—C(═O)C 1-8  alkyl, N(C 1-8  alkyl)-C(═O)C 1-8  alkyl, S—C 1-8  alkyl, S(═O) 2 C 1-8  alkyl, and S(═O) 2 O—C 1-8  alkyl, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O-methyl and OH; OCF 3 ; SH; SCF 3 ; S(═O) 2 OH; NH 2 ; C 3-10  cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted; benzyl, phenyl, pyridyl or thienyl, each unsubstituted or mono-, di- or trisubstituted with one, two or three substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , NH 2 , CN, C 1-8  alkyl, O—C 1-8  alkyl, CF 3 , OH, OCF 3 , C(═O)—OH, SCF 3  and S(═O) 2 OH.   
   
   
       5 . Substituted carboxamide according to  claim 1 , wherein
 R 1 , R 2 , R 3  and R 4  are each selected independently of one another from the group consisting of H; F; Cl; Br; I; NO 2 ; CF 3 ; CN; methyl; ethyl; n-propyl; isopropyl; cyclopropyl; n-butyl; sec-butyl; tert-butyl; CH 2 CF 3 ; C(═O)-methyl; C(═O)-ethyl; C(═O)—OH; C(═O)—O-methyl; C(═O)—O-ethyl; C(═O)—NH 2 ; C(═O)—N(methyl) 2 ; C(═O)—N(ethyl) 2 ; C(═O)—NH-methyl; C(═O)—NH-ethyl; C(═O)—N(methyl)(ethyl)OH; O-methyl; O-ethyl; O—(CH 2 ) 2 —O—CH 3 ; O—(CH 2 ) 2 —OH; OCF 3 ; O—C(═O)-methyl; O—C(═O)-ethyl; NR a R b , wherein R a  and R b  are selected independently of each other from the group consisting of H, methyl, ethyl, (CH 2 ) 2 —O—CH 3  and (CH 2 ) 2 —OH or R a  and R b  together with the nitrogen atom linking them form a pyrrolidinyl, piperidinyl, 4-methylpiperazinyl or morpholinyl; NHC(═O)-methyl; NHC(═O)-ethyl; SH; SCF 3 ; S-methyl; S-ethyl; S(═O) 2 OH; S(═O) 2 O-methyl; benzyl, phenyl, pyridyl, each unsubstituted or mono-, di- or trisubstituted with one, two or three substituents each selected independently of one another from the group consisting of F, Cl, Br, I, CN, methyl, ethyl, CF 3 , OH, O-methyl and OCF 3 .   
   
   
       6 . Substituted carboxamide according to  claim 1 , wherein
 R 5  is selected from the group consisting of H; F; Cl; Br; I; NO 2 ; CF 3 ; CN; methyl; ethyl; n-propyl; isopropyl; cyclopropyl; n-butyl; sec-butyl; tert-butyl; CH 2 CF 3 ; C(═O)-methyl; C(═O)-ethyl; C(═O)—OH; C(═O)—O-methyl; C(═O)—O-ethyl; C(═O)—NH 2 ; C(═O)—N(methyl) 2 ; C(═O)—N(ethyl) 2 ; C(═O)—NH-methyl;   C(═O)—NH-ethyl; C(═O)—N(methyl)(ethyl)O-methyl; O-ethyl; O—(CH 2 ) 2 —O—CH 3 ; O—(CH 2 ) 2 —OH; OCF 3 ; O—C(═O)-methyl; O—C(═O)-ethyl; NR a R b , wherein R a  and R b  are selected independently of each other from the group consisting of H, methyl, ethyl, (CH 2 ) 2 —O—CH 3 , (CH 2 ) 2 —OH, C(═O)-methyl, C(═O)-ethyl or R a  and R b  together with the nitrogen atom linking them form a pyrrolidinyl, piperidinyl, 4-methylpiperazinyl or morpholinyl; SH; SCF 3 ; S-methyl; S-ethyl; S(═O) 2 OH; S(═O) 2 O-methyl; benzyl, unsubstituted or mono-, di- or trisubstituted with one, two or three substituents each selected independently of one another from the group consisting of F, Cl, Br, I, CN, methyl, ethyl, CF 3 , OH, O-methyl and OCF 3 .   
   
   
       7 . Substituted carboxamide according to  claim 1 , wherein
 R 6  stands for the substructure (T1)   
     
       
         
         
             
             
         
       
     
     wherein
 R 8a  and R 8b  stand independently of each other for H; F; Cl; Br; I; NO 2 ; CF 3 ; CN; OH; OCF 3 ; NH 2 ; C 1-4  alkyl, O—C 1-4  alkyl, NH—C 1-4  alkyl, N(C 1-4  alkyl) 2 , each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O—C 1-4  alkyl, OH and OCF 3 ; C 3-10  cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C 1-4  alkyl, OH, ═O, O—C 1-4  alkyl, OCF 3 , NH 2 , NH—C 1-4  alkyl and N(C 1-4  alkyl) 2 ; 
 m stands for 0, 1, 2, 3 or 4; 
 Y stands for O or NR 9 ,
 wherein R 9  stands for H; C 1-4  alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, 
 Cl, Br, I, C 1-4  alkyl, OH, O—C 1-4  alkyl, OCF 3 , NH 2 , NH—C 1-4  alkyl and N(C 1-4  alkyl) 2 ; or for C 3-10  cycloalkyl, saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C 1-4  alkyl, OH, O—C 1-4  alkyl, OCF 3 , NH 2 , NH—C 1-4  alkyl and N(C 1-4  alkyl) 2 ; 
 
 n stands for 0 or 1,
 with the proviso that n does not stand for 1 if m denotes 0; 
 
 A stands for C 1-8  alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, ═O, O—C 1-4  alkyl, OCF 3 , C(═O)—OH, CF 3 , NH 2 , NH(C 1-4  alkyl), N(C 1-4  alkyl) 2 , SH, S—C 1-4  alkyl, SCF 3  and S(═O) 2 OH; C 3-10  cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-8  alkyl), N(C 1-8  alkyl) 2 , SH, S—C 1-8  alkyl, SCF 3 , S(═O) 2 OH, benzyl, phenyl, pyridyl and thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or, mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-8  alkyl), N(C 1-8  alkyl) 2 , SH, S—C 1-8  alkyl, SCF 3  and S(═O) 2 OH; aryl or heteroaryl, each unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-8  alkyl), N(C 1-8  alkyl) 2 , SH, S—C 1-8  alkyl, SCF 3 , S(═O) 2 OH, benzyl, phenyl, pyridyl and thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-8  alkyl), N(C 1-8  alkyl) 2 , SH, S—C 1-8  alkyl, SCF 3  and S(═O) 2 OH. 
 
   
   
       8 . Substituted carboxamide according to  claim 7 , wherein
 R 8a  and R 8b  stand independently of each other for H; F; Cl; Br; I; NO 2 ; CF 3 ; CN; methyl; ethyl; n-propyl; isopropyl; cyclopropyl; n-butyl; sec-butyl; tert-butyl; CH 2 CF 3 ; OH; O-methyl; O-ethyl; O—(CH 2 ) 2 —O—CH 3 ; O—(CH 2 ) 2 —OH; OCF 3 ; NH 2 ; NH-methyl; N(methyl) 2 ;   NH-ethyl; N(ethyl) 2 ; or N(methyl)(ethyl);   m stands for 1, 2 or 3;   n stands for 0;   A stands for C 1-4  alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, OH, O—C 1-4  alkyl, OCF 3  and CF 3 ; C 3-10  cycloalkyl, saturated, unsubstituted; phenyl, naphthyl, pyridyl, thienyl, each unsubstituted or mono- or di- or trisubstituted with one, two or three substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, O—C 1-4  alkyl, OCF 3 , C 1-4  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-4  alkyl), N(C 1-4  alkyl) 2 , SH, S—C 1-4  alkyl, SCF 3 , and S(═O) 2 OH.   
   
   
       9 . Substituted arboxamide according to  claim 1 , wherein
 R 7  is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, 2-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, n-hexyl, cyclopropyl; cyclobutyl, cyclopentyl, cyclohexyl, methyl cyclopropyl, methyl cyclobutyl, methyl cyclopentyl, methyl cyclohexyl, ethyl cyclopropyl, ethyl cyclobutyl, ethyl cyclopentyl, and ethyl cyclohexyl, each unsubstituted or mono- or polysubstituted with one or more substituents selected from the group consisting of F, Cl, Br, I, OCF 3 , SCF 3 , CF 3  and OC 1-8  alkyl; or phenyl, benzyl or phenethyl, each unsubstituted or mono- or polysubstituted with one or more substituents selected from the group consisting of F, Cl, Br, I, OCF 3 , SCF 3 , CF 3 , C 1-8  alkyl, OC 1-8  alkyl and CN.   
   
   
       10 . Substituted carboxamide according to  claim 1 , wherein
 R 1 , R 2 , R 3  and R 4  are each selected independently of one another from the group consisting of H; F; Cl; Br; I; NO 2 ; CF 3 ; CN; methyl; ethyl; C(═O)-methyl; OH; O-methyl; O—(CH 2 ) 2 —O—CH 3 ; OCF 3 ; O—C(═O)-methyl; NH 2 ; NH—C(═O)-methyl; N(methyl) 2 ; morpholinyl; S-methyl; SCF 3 ; benzyl and phenyl, each unsubstituted;   R 5  is selected from the group consisting of H; F; Cl; Br; I; NO 2 ; CF 3 ; CN; methyl; ethyl; C(═O)-methyl; O-methyl; O—(CH 2 ) 2 —O—CH 3 ; OCF 3 ; O—C(═O)-methyl; NH 2 ; NH—C(═O)-methyl; N(methyl) 2 ; morpholinyl; S-methyl; SCF 3 ; benzyl, unsubstituted;   R 6  stands for the substructure (T1-1)   
     
       
         
         
             
             
         
       
     
     wherein
 R 8a  and R 8b  stand independently of each other for H; F; Cl; Br; I; methyl; ethyl; n-propyl; 
 isopropyl; n-butyl; sec-butyl; tert-butyl; OH; O-methyl; O-ethyl; O—(CH 2 ) 2 —O—CH 3 ; or O—(CH 2 ) 2 —OH; 
 m stands for 1, 2 or 3; 
 A stands for methyl; ethyl; n-propyl; isopropyl; n-butyl; sec-butyl; tert-butyl; cyclopropyl; cyclobutyl; cyclopentyl; cyclohexyl; cycloheptyl; adamantyl; bicyclo[2.2.1]heptyl; bicyclo[2.2.2]octyl; phenyl, pyridyl, thienyl, each unsubstituted or mono-, di- or trisubstituted with one, two or three substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, O—C 1-4  alkyl, OCF 3 , C 1-4  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-4  alkyl), N(C 1-4  alkyl) 2 , SH, S—C 1-4  alkyl, SCF 3  and S(═O) 2 OH; 
 R 7  stands for
 C 1-8  alkyl or C 2-8  heteroalkyl, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CF 3 , CN, OH, ═O, C(═O)—OH, OCF 3 , NH 2 , S(═O) 2 OH, SH, SCF 3 , C 1-8  alkyl, O—C 1-8  alkyl, S—C 1-8  alkyl, NH—C 1-8  alkyl, N(C 1-8  alkyl) 2 , C 3-8  cycloalkyl or heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O—C 1-8  alkyl, OH and OCF 3 , and wherein the aforementioned C 3-10  cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C 1-8  alkyl, OH, ═O, O—C 1-8  alkyl, OCF 3 , NH 2 , NH—C 1-8  alkyl and N(C 1-8  alkyl) 2 ; 
 C 3-8  cycloalkyl or heterocyclyl or C 1-6  alkyl- or C 2-6  heteroalkyl-bridged C 3-8  cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, ═O, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-8  alkyl), N(C 1-8  alkyl) 2 , SH, S—C 1-8  alkyl, SCF 3 , S(═O) 2 OH, benzyl, phenyl, pyridyl, thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-8  alkyl), N(C 1-8  alkyl) 2 , SH, S—C 1-8  alkyl, SCF 3 , and S(═O) 2 OH; 
 and wherein optionally the alkyl chain or heteroalkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CF 3 , CN, OH, ═O, C(═O)—OH, OCF 3 , NH 2 , S(═O) 2 OH, SH, SCF 3 , C 1-8  alkyl, O—C 1-8  alkyl, S—C 1-8  alkyl, NH—C 1-8  alkyl, N(C 1-8  alkyl) 2 , C 3-8  cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O—C 1-8  alkyl, OH and OCF 3 ; and wherein the aforementioned C 3-10  cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C 1-8  alkyl, OH, ═O, O—C 1-8  alkyl, OCF 3 , NH 2 , NH—C 1-8  alkyl and N(C 1-8  alkyl) 2 ; 
 
 aryl or heteroaryl or C 1-6  alkyl- or C 2-6  heteroalkyl-bridged aryl or heteroaryl, each unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-8  alkyl), N(C 1-8  alkyl) 2 , SH, S—C 1-8  alkyl, SCF 3 , S(═O) 2 OH, benzyl, phenyl, pyridyl, thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C 1-8  alkyl), N(C 1-8  alkyl) 2 , SH, S—C 1-8  alkyl, SCF 3  and S(═O) 2 OH; 
 and wherein optionally the alkyl chain or heteroalkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO 2 , CF 3 , CN, OH, ═O, C(═O)—OH, OCF 3 , NH 2 , S(═O) 2 OH, SH, SCF 3 , C 1-8  alkyl, O—C 1-8  alkyl, S—C 1-8  alkyl, NH—C 1-8  alkyl, N(C 1-8  alkyl) 2 , C 3-10  cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, O—C 1-8  alkyl, OH and OCF 3 ; and wherein the aforementioned C 3-10  cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C 1-8  alkyl, OH, ═O, O—C 1-8  alkyl, OCF 3 , NH 2 , NH—C 1-8  alkyl and N(C 1-8  alkyl) 2 . 
 
   
   
       11 . Substituted carboxamide according to  claim 1 , wherein
 R 1 , R 2 , R 3  and R 4  each denote independently of one another H; F; Cl; Br; I; CF 3 ; OH; OCF 3 ; NH 2 ; SH; SCF 3 ; C 1-8  alkyl, or O—C 1-8  alkyl, each saturated or unsaturated, branched or unbranched, unsubstituted;   R 5  stands for H; F; Cl; Br; I; CF 3 ; OCF 3 ; NH 2 ; SH; SCF 3 ; C 1-8  alkyl, or O—C 1-8  alkyl, each saturated or unsaturated, branched or unbranched, unsubstituted;   R 6  stands for C 1-8  alkyl or C 2-8  heteroalkyl, each saturated, unsaturated, branched or unbranched, unsubstituted; C 3-10  cycloalkyl, saturated or unsaturated, unsubstituted; aryl or heteroaryl, each unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, OH, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, CF 3 , SH, S—C 1-8  alkyl, SCF 3 ; C 1-8  alkyl- or C 2-8  heteroalkyl-bridged C 3-10  cycloalkyl, saturated or unsaturated, unsubstituted; or C 1-8  alkyl- or C 2-8  heteroalkyl-bridged aryl or heteroaryl, each unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, OH, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, CF 3 , SH, S—C 1-8  alkyl, and SCF 3 , wherein the alkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted;   R 7  stands for C 1-8  alkyl or C 2-8  heteroalkyl, each saturated, unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, OH, ═O, O—C 1-8  alkyl;   C 3-10  cycloalkyl, saturated or unsaturated, unsubstituted; aryl or heteroaryl, each unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, OH, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, CF 3 , SCF 3 ; C 1-8  alkyl- or C 2-8  heteroalkyl-bridged C 3-10  cycloalkyl, saturated or unsaturated, unsubstituted, wherein the alkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted; or C 1-8  alkyl- or C 2-8  heteroalkyl-bridged aryl or heteroaryl, each unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, OH, O—C 1-8  alkyl, OCF 3 , C 1-8  alkyl, CF 3 , and SCF 3 , wherein the alkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted.   
   
   
       12 . Substituted carboxamide according to  claim 1 , wherein
 R 1 , R 2 , R 3  and R 4  are each selected independently of one another from the group consisting of H, F, Cl, CF 3  and OCF 3 ;   R 5  stands for methyl, OMe or —CH 2 O-methyl;   R 6  stands for the following substructure (T1)   
     
       
         
         
             
             
         
       
     
     wherein
 R 8a  and R 8b  stand independently of each other for H, 
 m stands for 1, 
 n for 0 and 
 A stands for phenyl, pyridyl or thienyl, each substituted 0, 1, 2 or 3 times with a substituent selected from the group consisting of F, Cl, Br, I, NO 2 , CN, OH, O—C 1-4  alkyl, OCF 3 , C 1-4  alkyl, C(═O)—OH, CF 3 , NH 2 , NH(C IA  alkyl), N(C 1-4  alkyl) 2 , SH, S—C 1-4  alkyl, SCF 3  and S(═O) 2 OH, and 
 R 7  stands for methyl, ethyl, isopropyl, tert-butyl or cyclopropyl. 
 
   
   
       13 . Substituted carboxamide according to  claim 1 , selected from the group consisting of:
 1 2-(Pentylthio)-N-(2-thienylmethyl)-3-quinoline carboxamide;   2 3-[[3[Oxo-(2-thienylmethylamino)methyl]quinolyl]thio]propanoic acid methyl ester;   3 2-(3-Cyclohexylpropylthio)-N-(2-thienylmethyl)-3-quinoline carboxamide;   4 2-(3-Phenylpropylthio)-N-(2-thienylmethyl)-3-quinoline carboxamide;   5 2-[2-(Phenylsulfonyl)ethylthio]-N-(2-thienyl-methyl)-3-quinoline carboxamide;   6 2-[3-(4-Fluorophenyl)propylthio]-N-(2-thienylmethyl)-3-quinoline carboxamide;   7 2-(Ethylthio)-N-(2-thienylmethyl)-3-quinoline carboxamide;   8 2-[2-(Phenylsulfonyl)ethylthio]-N-(2-thienyl-methyl)-6-(trifluoromethyl)-3-quinoline carboxamide;   9 2-[2-(Phenylsulfonyl)ethylthio]-N-(2-thienylmethyl)-7-(trifluoromethyl)-3-quinoline carboxamide;   10 2-[2-(Phenylsulfonyl)ethylthio]-N-(2-thienylmethyl)-5-(trifluoromethyl)-3-quinoline carboxamide;   11 2-(Pentylthio)-N-(2-thienylmethyl)-6-(trifluoromethyl)-3-quinoline carboxamide;   12 2-(Ethylthio)-N-(2-thienylmethyl)-6-(trifluoromethyl)-3-quinoline carboxamide;   13 N-(2-Thienylmethyl)-2-[2-[3-(trifluoromethyl)-phenyl]sulfonylethylthio]-3-quinoline carboxamide;   14 2-(Ethylthio)-N-(2-thienylmethyl)-7-(trifluoromethyl)-3-quinoline carboxamide;   15 2-(Pentylthio)-N-(2-thienylmethyl)-7-(trifluoromethyl)-3-quinoline carboxamide;   16 2-[2-(4-Fluorophenyl)sulfonylethylthio]-N-(2-thienylmethyl)-3-quinoline carboxamide;   17 2-[2-(p-Tolylsulfonyl)ethylthio]-N-(2-thienylmethyl)-3-quinoline carboxamide;   18 2-[2-(p-Tolylthio)ethylthio]-N-(2-thienylmethyl)-3-quinoline carboxamide;   19 2-[2-(Phenylsulfonyl)ethylthio]-N-(cyclohexylmethyl)-3-quinoline carboxamide;   20 2-[3-(p-Tolyl)propylthio]-N-(2-thienylmethyl)-3-quinoline carboxamide;   21 2-[2-(Phenylthio)ethylthio]-N-(2-thienylmethyl)-3-quinoline carboxamide;   22 2-[2-(Phenylsulfonyl)ethylthio]-N-(2-cyclohexylethyl)-3-quinoline carboxamide;   23 2-[2-(Phenylsulfonyl)ethylthio]-N-(3,3-dimethylbutyl)-3-quinoline carboxamide;   24 2-[2-[(4-Fluorophenyl)thio]ethylthio]-N-(2-thienylmethyl)-3-quinoline carboxamide;   25 N-(3,3-Dimethylbutyl)-2-(ethylthio)-4-methyl-7-(trifluoromethyl)-3-quinoline carboxamide;   26 3-(3-(Thiophen-2-ylmethylcarbamoyl)-6-(trifluoromethyl)quinolin-2-ylthio)propanoic acid methyl ester;   27 3-(3-(Thiophen-2-ylmethylcarbamoyl)-7-(trifluoromethyl)quinolin-2-ylthio)propanoic acid methyl ester;   28 N-(2,2-Dimethylpropyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   29 N-(Cycloheptylmethyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   31 N-[(3,4-Difluorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   32 N-[(2,4-Difluorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   33 2-Ethylsulfanyl-4-methyl-7-(trifluoromethyl)-N-[(3,4,5-trifluorophenyl)-methyl]-quinoline-3-carboxamide;   34 2-Ethylsulfanyl-4-methyl-7-(trifluoromethyl)-N-[(2,4,5-trifluorophenyl)-methyl]-quinoline-3-carboxamide;   35 2-Ethylsulfanyl-4-methyl-N-(pyridin-4-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   36 N-[(4-tert-Butylphenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   37 2-Ethylsulfanyl-4-methyl-N-(3-methylbutyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   38 2-Ethylsulfanyl-4-methyl-7-(trifluoromethyl)-N-[[3-(trifluoromethyl)phenyl]-methyl]-quinoline-3-carboxamide;   39 2-Ethylsulfanyl-4-methyl-N-phenethyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   40 2-Ethylsulfanyl-4-methyl-N-(3-phenylpropyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   41 2-Ethylsulfanyl-4-methyl-N-(pyridin-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   42 2-Ethylsulfanyl-4-methyl-N-(pyridin-3-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   43 2-Ethylsulfanyl-4-methyl-N-(naphthalen-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   44 2-Ethylsulfanyl-4-methyl-N-(thiazol-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   45 2-Ethylsulfanyl-4-methyl-N-([1,3,4]oxadiazol-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   47 N-[(3-Fluorophenyl)-methyl]-2-(isopropylsulfanyl)-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   48 2-(Cyclopentylsulfanyl)-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   49 2-(Butylsulfanyl)-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   50 N-[(3-Fluorophenyl)-methyl]-4-methyl-2-(pentylsulfanyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   51 N-[(3-Fluorophenyl)-methyl]-4-methyl-2-(1-methyl-propylsulfanyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   52 2-(Cyclohexylsulfanyl)-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   53 N-(2-Cyclopentylethyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   54 N-(3-Cyclopentylpropyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   55 2-Ethylsulfanyl-4-methyl-7-(trifluoromethyl)-N-[[4-(trifluoromethyl)phenyl]-methyl]-quinoline-3-carboxamide;   56 N-[(3-tert-Butylphenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   57 2-Ethylsulfanyl-4-methyl-N-(4-methylpentyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   58 2-Benzylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   59 2-Ethylsulfanyl-N-[(3-fluoro-2-methoxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   60 2-Ethylsulfanyl-N-[(5-fluoro-2-methoxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   61 N-[(3,4-Dimethylphenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   62 2-Ethylsulfanyl-4-methyl-7-(trifluoromethyl)-N-[[4-(trifluoromethylsulfanyl)-phenyl]-methyl]-quinoline-3-carboxamide;   63 N-(Cyclohexylmethyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   64 2-Ethylsulfanyl-4-methyl-N-(tetrahydropyran-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   65 2-Ethylsulfanyl-4-methyl-N-propyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   66 N-Butyl-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   67 2-Ethylsulfanyl-N-(2-methoxyethyl)-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   68 2-Ethylsulfanyl-4-methyl-N-pentyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   69 2-Ethylsulfanyl-4-methyl-N-[(5-methylthiophen-2-yl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide;   70 2-Ethylsulfanyl-4-methyl-N-[(4-methylthiophen-2-yl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide;   71 N-[(5-Chlorothiophen-2-yl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   72 2-Ethylsulfanyl-4-methyl-N-(2-thiophen-2-yl-ethyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   73 N-(5-Bicyclo[2.2.1]heptanylmethyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   74 N-Benzyl-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   75 2-Ethylsulfanyl-N-[(2-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   76 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   77 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   78 N-[(2-Chlorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   79 N-[(3-Chlorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   80 N-[(4-Chlorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   81 2-Ethylsulfanyl-4-methyl-N-(o-tolylmethyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   82 2-Ethylsulfanyl-4-methyl-N-(m-tolylmethyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   83 2-Ethylsulfanyl-4-methyl-N-(p-tolylmethyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   84 2-Ethylsulfanyl-N-[(2-methoxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   85 2-Ethylsulfanyl-N-[(3-methoxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   86 2-Ethylsulfanyl-N-[(4-methoxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   87 N-[(3,5-Difluorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   88 4-Methyl-2-methylsulfanyl-N-(thiophen-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   89 2-(tert-Butylsulfanyl)-4-methyl-N-(thiophen-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide;   90 N-(2,2-Dimethylpropyl)-2-ethylsulfanyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   91 2-Ethylsulfanyl-4-methyl-N-(thiophen-2-yl-methyl)-quinoline-3-carboxamide;   92 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide;   93 2-(tert-Butylsulfanyl)-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   94 2-(tert-Butylsulfanyl)-N-[(4-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   95 7-tert-Butyl-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide;   96 7-tert-Butyl-2-ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide;   97 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-7-methoxy-4-methyl-quinoline-3-carboxamide;   98 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-7-methoxy-4-methyl-quinoline-3-carboxamide;   99 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4,6-dimethyl-quinoline-3-carboxamide;   100 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4,6-dimethyl-quinoline-3-carboxamide;   101 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-6-methoxy-4-methyl-quinoline-3-carboxamide;   102 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-6-methoxy-4-methyl-quinoline-3-carboxamide;   103 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-6-(trifluoromethyl)-quinoline-3-carboxamide;   104 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-6-(trifluoromethyl)-quinoline-3-carboxamide;   105 2-Ethylsulfanyl-7-fluoro-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide;   106 2-Ethylsulfanyl-7-fluoro-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide;   107 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4,7-dimethyl-quinoline-3-carboxamide;   108 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4,7-dimethyl-quinoline-3-carboxamide;   109 2-Ethylsulfanyl-6,7-difluoro-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide;   110 2-Ethylsulfanyl-N-(furan-2-yl-methyl)-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   111 2-Ethylsulfanyl-4-methyl-N-[(5-methyl-furan-2-yl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide;   113 2-Ethylsulfanyl-N-[(3-hydroxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   114 N-[(3-Fluorophenyl)-methyl]-4-methyl-2-methylsulfanyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   115 N-[(4-Fluorophenyl)-methyl]-4-methyl-2-methylsulfanyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   116 2-Ethylsulfanyl-6-fluoro-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide;   117 2-Ethylsulfanyl-6-fluoro-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide;   118 2-Ethylsulfanyl-6,7-difluoro-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide;   119 2-Ethylsulfanyl-N-[(4-hydroxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide;   120 2-Ethylsulfanyl-8-fluoro-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide;   121 2-Ethylsulfanyl-8-fluoro-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide;   123 2-Ethylsulfanyl-5-fluoro-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide;   124 2-Ethylsulfanyl-5-fluoro-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide;   125 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-5-methoxy-4-methyl-quinoline-3-carboxamide;   126 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-5-methoxy-4-methyl-quinoline-3-carboxamide;   127 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-5-hydroxy-4-methyl-quinoline-3-carboxamide;   128 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-6-hydroxy-4-methyl-quinoline-3-carboxamide;   129 2-Ethylsulfanyl-N[(3-fluorophenyl)-methyl]-7-hydroxy-4-methyl-quinoline-3-carboxamide;   133 7-Dimethylamino-2-ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide;   134 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-7-morpholin-4-yl-quinoline-3-carboxamide;   135 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-7-morpholin-4-yl-quinoline-3-carboxamide;   136 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-8-(trifluoromethyl)-quinoline-3-carboxamide;   137 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-8-(trifluoromethyl)-quinoline-3-carboxamide;   138 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-8-methoxy-4-methyl-quinoline-3-carboxamide;   139 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-8-methoxy-4-methyl-quinoline-3-carboxamide;   140 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-8-hydroxy-4-methyl-quinoline-3-carboxamide;   141 7-Dimethylamino-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide;   142 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyloxy)-quinoline-3-carboxamide;   143 4-Ethyl-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide;   144 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-isopropyl-7-(trifluoromethyl)-quinoline-3-carboxamide;
 and the physiologically compatible salts thereof. 
   
   
   
       14 . A pharmaceutical composition comprising at least one substituted carboxamide according to  claim 1  or the compound N-benzyl-2-(3-chloro-2-hydroxypropylthio)-4-(2,4-dichlorophenyl)quinoline-3-carboxamide,
 in the form of an individual stereoisomer or a mixture thereof, in the form of a free compound and/or a physiologically compatible thereof, and optionally one or more suitable additives and/or auxiliary substances and/or optionally further active ingredients.   
   
   
       15 . A method of treating a disorder in a patient in need of such treatment, said disorder being at least one disorder selected from the group consisting of pain, epilepsy, urinary incontinence, anxiety states, dependency, mania, bipolar disorders, migraine, cognitive diseases, and dystonia-associated dyskinesias, said method comprising administering to said patient an amount effective to treat said disorder of at least one substituted carboxamide according to  claim 1  or the compound N-benzyl-2-(3-chloro-2-hydroxypropylthio)-4-(2,4-dichlorophenyl)quinoline-3-carboxamide,
 each in the form of an individual stereoisomer or a mixture thereof, in the form of a free compound and/or a physiologically compatible salt thereof.   
   
   
       16 . (canceled)