Analyte Monitoring Device and Methods of Use

Abstract

An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

1 . (canceled) 
     
     
         2 . A method for processing data from a glucose sensor, comprising:
 receiving a signal from a glucose sensor;   detecting signal artifacts in the signal, wherein detecting comprises evaluating the signal against one or more predetermined signal artifacts criteria;   estimating one or more glucose values based at least in part on the signal; and   replacing at least some signal artifacts using the one or more estimated glucose values in response to detection of signal artifacts that meet the one or more predetermined signal artifacts criteria.   
     
     
         3 . The method of  claim 2 , wherein the glucose sensor is selected from the group consisting of a non-invasive glucose sensor, a minimally invasive glucose sensor, and an invasive glucose sensor. 
     
     
         4 . The method of  claim 2 , wherein the glucose sensor is selected from the group consisting of an enzymatic glucose sensor, a chemical glucose sensor, a physical glucose sensor, an electrochemical glucose sensor, a spectrophotometric glucose sensor, a polarimetric glucose sensor, a calorimetric glucose sensor, an iontophoretic glucose sensor, and a radiometric glucose sensor. 
     
     
         5 . The method of  claim 2 , further comprising calibrating the signal to provide calibrated glucose values. 
     
     
         6 . The method of  claim 5 , wherein detecting is performed on the calibrated glucose values. 
     
     
         7 . The method of  claim 6 , wherein detecting comprises evaluating at least one of rate-of-change, acceleration, and physiologically feasibility. 
     
     
         8 . The method of  claim 2 , wherein the one or more predetermined signal artifacts criteria comprise an amplitude criterion. 
     
     
         9 . The method of  claim 2 , wherein the one or more predetermined signal artifacts criteria comprise a duration criterion. 
     
     
         10 . The method of  claim 2 , wherein the one or more predetermined signal artifacts criteria comprise a rate-of-change criterion. 
     
     
         11 . The method of  claim 2 , wherein the one or more predetermined signal artifacts criteria comprise a frequency content criterion. 
     
     
         12 . The method of  claim 2 , wherein the step of estimating one or more glucose values comprises filtering the signal using at least one of a linear or non-linear regression, a trimmed mean, a non-recursive filter, a finite impulse response filter, a recursive filter, an infinite impulse response filter, a maximum average algorithm, and a Cone of Possibility Replacement Method to provide one or more filtered glucose values. 
     
     
         13 . The method of  claim 12 , further comprising selectively outputting either unfiltered glucose values or filtered glucose values in response to the detecting step, wherein replacing at least some signal artifacts using one or more estimated glucose values comprises outputting filtered glucose values. 
     
     
         14 . The method of  claim 2 , wherein estimating is performed substantially continually. 
     
     
         15 . The method of  claim 2 , wherein estimating is triggered in response to detection of signal artifacts that meet the one or more predetermined signal artifacts criteria. 
     
     
         16 . The method of  claim 2 , wherein replacing comprises outputting data representative of the one or more estimated glucose values, including at least one of a numeric representation of the one or more estimated glucose values, an indication of directional trend of the one or more estimated glucose values, and a graphical representation of the one or more estimated glucose values in response to detection of signal artifacts that meet the one or more predetermined signal artifacts criteria.