US2010221840A1PendingUtilityA1

Methods for testing for and inhibiting the development of huntington's disease

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Individually held — no corporate assignee on recordPriority: Sep 4, 2002Filed: Mar 8, 2010Published: Sep 2, 2010
Est. expirySep 4, 2022(expired)· nominal 20-yr term from priority
Inventors:James A. Carnazza
G01N 33/6896A61K 31/56A61K 31/57C12Q 1/6883C12Q 2600/156G01N 2800/2835
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Claims

Abstract

This invention relates to Huntington's disease and more specifically to methods for testing and inhibiting the development of Huntington's disease.

Claims

exact text as granted — not AI-modified
1 . A method of binding estrogen to huntingtin (HD) protein, in vitro, wherein the method comprises contacting estrogen with the HD protein to thereby allow formation of a complex between estrogen and the HD protein. 
   
   
       2 . The method of  claim 2 , wherein the HD protein has at least 23 poly-glutamine repeats. 
   
   
       3 . The method of  claim 2 , wherein the HD protein has at least 38 poly-glutamine repeats. 
   
   
       4 . The method of  claim 1 , wherein the complex is labeled. 
   
   
       5 . The method of  claim 4 , further including determining the presence or absence of the complex. 
   
   
       6 . The method of  claim 5 , further including determining the level of the complex, as compared to a sample that lacks HD protein. 
   
   
       7 . A method of determining the presence or absence of a complex between estrogen and huntingtin protein in vitro, wherein the method comprises:
 a) contacting labeled estrogen with the HD protein to thereby allow formation of a complex between estrogen and the HD protein; and   b) determining the presence or absence of the complex.   
   
   
       8 . The method of  claim 7 , further including determining the level of the complex, as compared to a sample that lacks HD protein. 
   
   
       9 . The method of  claim 8 , wherein the HD protein has at least 23 poly-glutamine repeats. 
   
   
       10 . The method of  claim 9 , wherein the HD protein has at least 38 poly-glutamine repeats.

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