Manufacturing execution system (MES) and methods of monitoring glycol manufacturing processes utilizing functional nanomaterials

Abstract

A Manufacturing Execution System (MES) and related methods of monitoring a glycol manufacturing processes are disclosed herein. The methods are useful to provide a plurality of analysis to the glycol manufacturing process. Consequently, the manufacturing execution system and methods provide a means to perform validation and quality manufacturing on an integrated level whereby glycol manufacturers can achieve data and product integrity and ultimately minimize cost.

1 ) A method comprising,
 a) establishing an acceptance criteria for a glycol manufacturing process;   b) monitoring data generated by a device used in said glycol manufacturing process, wherein said device is operably linked to a nanosensor;   c) analyzing the data against the acceptance criteria; and   d) determining whether the acceptance criteria is met to make a quality based assessment   
     
     
         2 ) The method of  claim 1 , wherein the device is a solvent recovery system. 
     
     
         3 ) The method of  claim 1 , wherein the device is a pure water system. 
     
     
         4 ) The method of  claim 1 , wherein the device is a chromatography system. 
     
     
         5 ) The method of  claim 1 , wherein the analyzing is failure modes and effects analysis. 
     
     
         6 ) The method of  claim 1 , wherein the monitoring is continuous. 
     
     
         7 ) The method of  claim 1 , further comprising maintaining the data over time to create a historic record. 
     
     
         8 ) A computer memory having computer executable instructions to perform the method of  claim 1 . 
     
     
         9 ) A kit comprising the computer memory having computer executable instructions of  claim 8 . 
     
     
         10 ) A manufacturing execution system comprising,
 a) A computer memory having computer executable instructions used to monitor a glycol manufacturing process;   b) A nanosensor;   c) An input/output device;   d) A plurality of hardware devices used of manufacture glycol.   
     
     
         11 ) The manufacturing execution system of  claim 10 , wherein the hardware device is selected from the group consisting of blenders, bio-reactors, capping machines, chromatography systems, dry heat sterilizers, freezers, filling equipment, filtration systems, incubators, labelers, dryers, mixing tanks, modular cleanrooms, neutralization systems, process tanks, vessels, refrigerators, separation systems, specialty gas systems, solvent recovery systems, waste inactivation systems/“kill” systems, vial inspection systems, vial washers, water for injection (WFI) systems, and pure water systems. 
     
     
         12 ) The nanosensor of  claim 10 , wherein the nanosensor is a biosensor. 
     
     
         13 ) The nanosensor of  claim 10 , wherein the nanosensor is an optical sensor. 
     
     
         14 ) The nanosensor of  claim 10 , wherein the nanosensor is a chemical sensor. 
     
     
         15 ) The chemical sensor of  claim 14 , wherein the chemical sensor is selected from the group consisting of oxygen sensors (a.k.a. λ sensors), ion-selective electrodes, pH glass electrodes, and redox electrodes. 
     
     
         16 ) The input/output device of  claim 10 , wherein the input/output device is a analog to digital converter. 
     
     
         17 ) A kit comprising the manufacturing execution system of  claim 10 .