US2010210014A1PendingUtilityA1

Nuclear reprogramming factor and induced pluripotent stem cells

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Assignee: UNIV KYOTOPriority: Dec 13, 2005Filed: Feb 18, 2010Published: Aug 19, 2010
Est. expiryDec 13, 2025(expired)· nominal 20-yr term from priority
Inventors:Shinya Yamanaka
C12N 5/0696C12N 2501/604C12N 2501/602A61P 43/00C12N 2501/603C12N 2501/60C07K 14/4702C12N 2510/00C12N 2740/15043
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Claims

Abstract

The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including screening and testing methods as well as methods of stem cell therapy. The present invention also relates to somatic cells derived by inducing differentiation of the aforementioned iPS cells.

Claims

exact text as granted — not AI-modified
1 . A method for preparing an induced pluripotent stem cell, which comprises: incubating in the presence of basic fibroblast growth factor a somatic cell in which the following three genes: Oct3/4, Klf4 and Sox2 are introduced. 
     
     
         2 . The method of  claim 1 , wherein the somatic cell is a human cell.

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