Intraluminal device with a coating containing a therapeutic agent

Abstract

The invention relates to an intraluminal device, in particular an intraluminal prosthesis, shunt, catheter or local drug delivery device, provided with at least one coating containing a therapeutic agent comprised in a matrix which sticks to the intraluminal device, characterised in that said matrix is formed by a biocompatible oil or fat, which oil or fat is a chemically hardened oil or fat.

1 . An intraluminal device, in particular an intraluminal prosthesis, shunt, catheter or local drug delivery device, provided with at least one coating containing a therapeutic agent comprised in a matrix which sticks to the intraluminal device, characterised in that said matrix is formed by a biocompatible oil or fat, which oil or fat is a chemically hardened oil or fat. 
     
     
         2 . The device according to  claim 1 , characterized in that said chemically hardened oil or fat is a partially hydrogenated oil or fat. 
     
     
         3 . The device according to  claim 1 , characterised in that said chemically hardened oil or fat comprises unsaturated fatty acid chains but is substantially free of trans isomers of unsaturated fatty acid chains. 
     
     
         4 . The device according to  claim 1 , characterized in that said chemically hardened oil or fat is obtained by a method involving removal of trans isomers of said hardened oil or fat. 
     
     
         5 . The device according to  claim 1 , characterised in that said therapeutic agent comprises at least one therapeutic agent selected from the group consisting of immunosuppressants, anti-inflammatories, anti-proliferatives, anti-migratory agents, anti-fibrotic agents, proapoptotics, calcium channel blockers, anti-neoplastics, antibodies, anti-thrombotics, anti-platelet agents, IIb/IIIa blockers, antiviral agents, anti-cancer agents, chemotherapeutics, thrombolytics, vasodilators, antibiotics, growth factor antagonists, free radical scavengers, radiopaque agents, anti-angiogenesis agents, angiogenesis drugs, cyclooxygenase inhibitors, phosphodiesterase inhibitors, cytokine inhibitors, nitrogen oxide donors, and cytokine activators. 
     
     
         6 . A device according to  claim 1 , characterised in that said oil or fat comprises fatty acids and/or one or more derivatives thereof. 
     
     
         7 . The device according to  claim 1  wherein said oil or fat comprises one or more triglycerides composed of glycerol and one or more fatty acids. 
     
     
         8 . The device according to  claim 6 , characterised in that said fatty acids comprise omega-3 fatty acids. 
     
     
         9 . The device according to  claim 8 , characterised in that said fatty acids comprise eicosapantaenoic acid and/or decosahexaenoic acid. 
     
     
         10 . The device according to  claim 1 , characterised in that said device is an endovascular prosthesis. 
     
     
         11 . An intraluminal device, comprising:
 At least one coating containing a therapeutic agent comprised in a therapeutic matrix which covers at least a portion of the device, said therapeutic matrix disposed to deliver the therapeutic agent to tissue of a patient upon implantation in said patient, and said therapeutic matrix formed by a chemically hardened oil or fat, wherein the chemically hardened oil or fat matrix comprises triglycerides in an amount of more than 70% by weight, wherein the triglycerides comprise unsaturated omega-3 fatty acids in an amount of more than 15% by weight.