US2010197895A1PendingUtilityA1

Antibodies to human tumor necrosis factor receptor

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Assignee: ZYMOGENETICS INCPriority: Nov 7, 2000Filed: May 29, 2009Published: Aug 5, 2010
Est. expiryNov 7, 2020(expired)· nominal 20-yr term from priority
Inventors:Jane A. GrossWenfeng XuRandal M. HenneFrancis J. Grant
C07K 14/7151A61P 35/02C07K 2319/30A61P 37/02C07K 2319/00A61P 35/00
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Claims

Abstract

Tumor necrosis factors and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human tumor necrosis factor receptor designated as “Ztnfr12.”

Claims

exact text as granted — not AI-modified
1 . An antibody or antibody fragment that specifically binds an isolated polypeptide comprising amino acid residues 1 to 69 of the amino acid sequence of SEQ ID NO:2. 
     
     
         2 . An antibody or antibody fragment that specifically binds an isolated polypeptide consisting essentially of amino acid residues 1 to 69 of the amino acid sequence of SEQ ID NO:2, wherein said polypeptide binds to ztnfr12 ligand. 
     
     
         3 . An antibody or antibody fragment that specifically binds an isolated polypeptide consisting of amino acid residues 1 to 69 of the amino acid sequence of SEQ ID NO:2. 
     
     
         4 . The antibody of  claim 1 , wherein the antibody is a polyclonal antibody or a fragment thereof. 
     
     
         5 . The antibody of  claim 1  wherein the antibody is a murine monoclonal antibody or a humanized derivative thereof. 
     
     
         6 . The antibody of  claim 1  wherein the antibody is a human monoclonal antibody. 
     
     
         7 . The antibody of  claim 3  wherein the antibody is a polyclonal antibody or a fragment thereof. 
     
     
         8 . The antibody of  claim 3  wherein the antibody is a murine monoclonal antibody or a humanized derivative thereof. 
     
     
         9 . The antibody of  claim 3  wherein the antibody is a human monoclonal antibody 
     
     
         10 . An antibody or antibody fragment that specifically binds an isolated polypeptide comprising amino acid residues 1 to 79 of the amino acid sequence of SEQ ID NO:2. 
     
     
         11 . An antibody or antibody fragment that specifically binds an isolated polypeptide consisting essentially of amino acid residues 1 to 79 of the amino acid sequence of SEQ ID NO:2, wherein said polypeptide binds to ztnfr12 ligand. 
     
     
         12 . An antibody or antibody fragment that specifically binds an isolated polypeptide consisting of amino acid residues 1 to 79 of the amino acid sequence of SEQ ID NO:2. 
     
     
         13 . The antibody of  claim 10 , wherein the antibody is a polyclonal antibody or a fragment thereof. 
     
     
         14 . The antibody of  claim 10  wherein the antibody is a murine monoclonal antibody or a humanized derivative thereof. 
     
     
         15 . The antibody of  claim 10  wherein the antibody is a human monoclonal antibody 
     
     
         16 . The antibody of  claim 13 , wherein the antibody is a polyclonal antibody or a fragment thereof. 
     
     
         17 . The antibody of  claim 13  wherein the antibody is a murine monoclonal antibody or a humanized derivative thereof. 
     
     
         18 . The antibody of  claim 13  wherein the antibody is a human monoclonal antibody.

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