US2010197689A1PendingUtilityA1
Novel processes for the preparation of piperazinyl and diazapanyl benzamide derivatives
Individually held — no corporate assignee on recordPriority: Oct 31, 2005Filed: Apr 19, 2010Published: Aug 5, 2010
Est. expiryOct 31, 2025(expired)· nominal 20-yr term from priority
Inventors:Neelakandha S. ManiDavid C. PalmerChennagiri R. PanditMayra B. ReyesTong XiaoSergio Cesco-Cancian
A61P 43/00A61P 25/06A61P 25/08A61P 25/28A61P 17/04C07D 211/14C07D 295/182A61P 11/02C07D 295/192C07D 413/04A61P 11/06C07D 207/06C07D 295/18
38
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Claims
Abstract
The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides, useful for the treatment of disorders and conditions mediated by the histamine receptor.
Claims
exact text as granted — not AI-modified1 - 47 . (canceled)
48 . A crystalline succinate salt of (4-isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl-phenyl)-methanone.
49 . The salt of claim 48 , wherein the succinate salt is a mono-succinate salt.
50 . A crystalline mono-succinate salt of (4-isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl-phenyl)-methanone comprising the following X-ray diffraction peaks:
Position [° 2θ]
d-spacing [Å]
8.782
10.0698
13.161
6.7274
14.587
6.0728
15.961
5.5527
17.308
5.1237
17.555
5.0520
19.767
4.4915
20.210
4.3941
20.415
4.3503
23.802
3.7383
26.429
3.3728
51 . A crystalline mono-succinate salt of (4-isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl-phenyl)-methanone comprising the following X-ray diffraction peaks:
Position [° 2θ]
d-spacing [Å]
8.782
10.0698
13.161
6.7274
17.555
5.0520
23.802
3.7383
26.429
3.3728
52 . A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of claim 49 .
53 . A pharmaceutical composition made by mixing a compound of claim 49 and a pharmaceutically acceptable carrier.
54 . A process for making a pharmaceutical composition comprising mixing a compound of claim 49 and a pharmaceutically acceptable carrier.Join the waitlist — get patent alerts
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