Topical composition, topical composition precursor, and methods for manufacturing and using

Abstract

A tropical composition is provided. The topical composition can be prepared by diluting a topical composition precursor with water and adding additional components, if desired. The topical composition precursor can be prepared by melt processing a hydrophobic polymer composition that includes repeating pyrrolidone/alkylene groups wherein the alkylene groups contain at least 10 carbon atoms, and a hydrophilic polymer composition including repeating carboxylic groups and/or repeating hydroxyl groups. A topical composition precursor and methods for manufacturing and using a topical composition are provided by the invention.

1 . A topical composition comprising:
 (a) a complex of poly(vinylpyrrolidone/alkylene) polymer, wherein the alkylene group contains at least about 10 carbon atoms, and at least one of:
 (i) cellulose; 
 (ii) derivatives of cellulose; 
 (iii) carboxymethyl cellulose; 
 (iv) poly(maleic acid/methylvinylether) copolymer; 
   (b) at least 30 wt. % water; and   (c) a pharmacologically active agent for topical applications.   
   
   
       2 . A topical composition according to  claim 1 , wherein the poly(vinylpyrrolidone/alkylene) polymer comprises at least two different poly(vinylpyrrolidone/alkylene) polymers, wherein the alkylene group of each polymer contains at least about 10 carbon atoms. 
   
   
       3 . A topical composition according to  claim 2 , wherein the at least two different poly(vinylpyrrolidone/alkylene) polymers comprises a first poly(vinylpyrrolidone/alkylene) polymer and a second poly(vinylpyrrolidone/alkylene) polymer, wherein the first poly(vinylpyrrolidone/alkylene) polymer is provided at a concentration of between about 5 wt. % and about 54 wt. %, based on the weight of the at least two different poly(vinylpyrrolidone/alkylene) polymer. 
   
   
       4 . A topical composition according to  claim 1 , wherein the poly(vinylpyrrolidone/alkylene) polymer comprises poly(vinylpyrrolidone/1-eicosene). 
   
   
       5 . A topical composition according to  claim 1 , wherein the poly(vinylpyrrolidone/alkylene) polymer comprises poly(vinypyrrolidone/hexadecene). 
   
   
       6 . A topical composition according to  claim 1 , wherein the topical composition comprises between about 70 wt. % and about 96 wt. % water. 
   
   
       7 . A topical composition according to  claim 1 , wherein the pharmacologically active agent comprises at least one of antimicrobial agents, antifungal agents, anti-inflammatory agents, anti-viral agents, or vitamins. 
   
   
       8 . A topical composition according to  claim 1 , wherein the composition comprises poly(maleic acid/methylvinylether) copolymer having a weight average molecular weight of about 50,000 to about 4,000,000. 
   
   
       9 . A topical composition according to  claim 1 , wherein the composition further comprises about 0.5 wt. % to about 5 wt. % surfactant. 
   
   
       10 . A topical composition according to  claim 9 , wherein the surfactant comprises at least one of an ethoxylated surfactant, a propoxylated surfactant, an ethoxylated-propoxylated surfactant, or a mixture thereof. 
   
   
       11 . A topical composition according to  claim 1 , wherein the complex comprises cellulose. 
   
   
       12 . A topical composition according to  claim 1 , wherein the complex comprises carboxymethyl cellulose. 
   
   
       13 . A topical composition according to  claim 1 , wherein the complex comprises a ratio of pyrrolidone groups to a combination of carboxylic acid and hydroxyl groups of about 1:1 to about 5:1. 
   
   
       14 . A topical composition according to  claim 1 , wherein the complex comprises a ratio of pyrrolidone groups to a combination of carboxylic acid and hydroxyl groups of about 1.5:1 to about 3:1. 
   
   
       15 . A topical composition according to  claim 1 , wherein the complex is formed as a result of melt mixing in the presence of less than about 1 wt. % water. 
   
   
       16 . A topical composition according to  claim 1 , wherein the pharmacologically active agent comprises an antifungal agent comprising at least one of sulconazole, naftifine, morpholine, allylamine, triazole, clotrimazole, or miconazole nitrate. 
   
   
       17 . A topical composition according to  claim 1 , wherein the pharmacologically active agent comprises an antimicrobial agent comprising a quaternary ammonium compound or a peroxygen compound. 
   
   
       18 . A topical composition according to  claim 1 , wherein the pharmacologically active agent comprises an antimicrobial agent comprising a chlorinated diphenylether. 
   
   
       19 . A topical composition according to  claim 1 , wherein the pharmacologically active agent comprises α-hydroxy acid.