US2010168401A1PendingUtilityA1

Method, composition and kit for detecting phosphatidylserine (PS) on cell membranes

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Individually held — no corporate assignee on recordPriority: Jun 30, 2003Filed: Mar 8, 2010Published: Jul 1, 2010
Est. expiryJun 30, 2023(expired)· nominal 20-yr term from priority
Inventors:Gary GilbertJialan ShiChristian W. HeegaardJan T. Rasmussen
A61K 9/0019G01N 33/92
37
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Claims

Abstract

A method, composition and kit for detecting the presence of a phospholipid, such as phosphatidylserine, on a cell membrane is provided. A binding agent including lactadherin, a fragment of lactadherin, a functional equivalent of lactadherin, or a functional equivalent of a fragment of lactadherin, is used to detect the presence of any phospholipid.

Claims

exact text as granted — not AI-modified
1 . A kit for detecting the presence of a phospholipid in a biological material, comprising:
 a) at least one binding agent selected from the group consisting of lactadherin, a fragment of lactadherin, a functional equivalent of lactadherin, and a functional equivalent of a fragment of lactadherin; and   b) instructions for use of the binding agent.   
   
   
       2 . The kit of  claim 1 , wherein:
 the phospholipid comprises phosphatidylserine.   
   
   
       3 . The kit of  claim 1 , wherein:
 the phospholipid comprises a phospho-L-serine moiety of phosphatidylserine.   
   
   
       4 . A probe for detecting the presence of a phospholipid in a biological material, comprising:
 one or more of lactadherin, a fragment of lactadherin, a functional equivalent of lactadherin, or a functional equivalent of a fragment of lactadherin.   
   
   
       5 . The probe of  claim 4 , wherein:
 the phospholipid comprises phosphatidylserine.

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