Protein stabilizer

Abstract

An excellent protein stabilizer is provided, which has the following effects: (1) low probability with contamination of pathogens, (2) the effect of stabilization on photoproteins, and (3) minimization of loss of activity under lyophilizing conditions. A peptide from fish is used as the active ingredient for the protein stabilizer.

1 . A protein stabilizer, comprising a peptide from fish. 
     
     
         2 . The protein stabilizer according to  claim 1 , wherein the peptide from the fish is a peptide obtained by hydrolyzing collagen or gelatin from the fish. 
     
     
         3 . The protein stabilizer according to  claim 1 , wherein a weight average molecular weight of the peptide from the fish is in a range of 500-3,000. 
     
     
         4 . The protein stabilizer according to  claim 1 , wherein the protein is a calcium-binding photoprotein. 
     
     
         5 . The protein stabilizer according to  claim 4 , wherein the calcium-binding photoprotein is selected from one or more of aequorin, obelin, clytin, mitrocomin, mineopsin, bervoin, and a variant thereof. 
     
     
         6 . A protein composition, comprising the stabilizer according to  claim 1  and a protein. 
     
     
         7 . The protein composition according to  claim 6 , wherein a weight ratio of the peptide from the fish and the protein (peptide from fish/protein) is in a range of 10/1-10000/1. 
     
     
         8 . The protein composition according to  claim 6 , wherein the protein is a calcium-binding photoprotein. 
     
     
         9 . The protein composition according to  claim 8 , wherein the calcium-binding photoprotein is selected from one or more of aequorin, obelin, clytin, mitrocomin, mineopsin, bervoin, and a variant thereof. 
     
     
         10 . The protein composition according to  claim 6 , wherein the protein composition is in a lyophilized form. 
     
     
         11 . A method for stabilizing a protein, comprising allowing the protein stabilizer according to  claim 1  and the protein to be in the same system. 
     
     
         12 . The method for stabilizing a protein according to  claim 11 , wherein the protein is a calcium-binding photoprotein. 
     
     
         13 . The method for stabilizing a protein according to  claim 12 , wherein the calcium-binding photoprotein is selected from one or more of aequorin, obelin, clytin, mitrocomin, mineopsin, bervoin, and a variant thereof. 
     
     
         14 . A method for stabilizing a protein, comprising lyophilizing the protein composition according to  claim 6 . 
     
     
         15 . A kit, comprising the protein composition according to  claim 6 .