Method of treating vascular injuries induced by an excess of plasma lipids using combinations of vasoprotective agents

Abstract

Combinations of vasoprotective agents useful for the prevention and the treatment of vascular injuries induced by an excess of plasma lipids comprising polycosanols, tocotriends and/or lycopene, procyanidole oligomers and vegetable oil rich in insaturated fatty acids.

1 . A method for treating vascular injuries induced by an excess of plasma lipids, comprising administering to a subject in need thereof a combination of an effective amount of:
 one or more polycosanols or esters thereof, either pure or as extracts;   at least one of tocotrienol and lycopene;   one or more procyanidole oligomers optionally complexed with phospholipids; and   a vegetable oil rich in ω-3, ω-6 unsaturated fatty acids, wherein the composition is a pharmaceutical, dietetic or nutritional composition.   
   
   
       2 . The method as claimed in  claim 1 , wherein the vegetable oil is selected from  Enothera biennis, Ribes nigrum  and  Portulaca oleracea  oil. 
   
   
       3 . The method as claimed in  claim 2 , wherein the vegetable oil is  Enothera biennis  oil. 
   
   
       4 . The method as claimed in  claim 1 , wherein the composition further comprises luteolin or a 7,3′, 4′-hydroxyethyl derivative thereof. 
   
   
       5 . The method as claimed in  claim 1 , wherein the composition comprises polycosanol esters, wherein the polycosanol esters are polycosanols esterified with ferulic acid or other substituted cinnamates. 
   
   
       6 . The method as claimed in  claim 1 , wherein the composition comprises procyanidole oligomers derived from the group consisting of  Vitis vinifera, Camellia sinesis, Aesculus hippocastanum,  and  Olea europa.    
   
   
       7 . The method as claimed in  claim 1 , wherein the composition comprises 5 to 30 mg of polycosanols, 1 to 50 mg of tocotrienol or lycopene, 100 to 320 mg of proanthocyanidins complexed with phospholipids, and 150 to 300 mg of vegetable oil, per unitary dosage form. 
   
   
       8 . The method as claimed in  claim 1 , wherein the composition comprises tocotrienol. 
   
   
       9 . The method as claimed in  claim 1 , wherein the vascular injuries induced by an excess of plasma lipids is hyperlipidemia with carotid plaques.