US2010152064A1PendingUtilityA1
siRNA targeting BCL2L1
Est. expiryNov 14, 2022(expired)· nominal 20-yr term from priority
A61P 35/00A61P 37/02A61P 3/10A61P 35/02A61P 25/28C12N 15/1135A61P 13/12C12N 2320/11A61P 21/00A61K 31/713C12Y 502/01008C12N 2310/14C12N 15/1137C12N 15/1048G16B 20/00C12N 2320/10C12N 15/1136C12N 15/1138C12N 15/113C12Y 113/12007C12N 15/111G16B 20/20G16B 20/50
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Claims
Abstract
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.
Claims
exact text as granted — not AI-modified1 . An siRNA comprising a sense region and an antisense region, wherein said sense region and said antisense region are at least 90% complementary, said sense region and said antisense region together form a duplex region comprising 18-30 base pairs, and said sense region comprises a sequence that is at least 90% similar to a sequence selected from the group consisting of:
AAAGUGCAGUUCAGUAAUA,
(SEQ ID NO 438)
GGAAAUGACCAGACACUGA,
(SEQ ID NO 439)
GGAUACAGCUGGAGUCAGU,
(SEQ ID NO 440)
GAGACUAGAUUGCCUUUGU,
(SEQ ID NO 441)
GAGCCCAUCCCUAUUAUAA,
(SEQ ID NO 442)
GGAGGGCCCUACCUGAUUG,
(SEQ ID NO 443)
GCUCUCUGCUGUACAUAUU,
(SEQ ID NO 444)
GGAGGCAGGCGACGAGUUU,
(SEQ ID NO 445)
AAAGGAGGCUGGCAGGUAU,
(SEQ ID NO 446)
CCAGAAAGGAGACUAGAUU,
(SEQ ID NO 447)
GUUGAGCCCAUCCCUAUUA,
(SEQ ID NO 448)
CAAAGGAGGCUGGCAGGUA,
(SEQ ID NO 449)
GUCCAAAUGUCCUCCAGAA,
(SEQ ID NO 450)
GGAGUCAGUUUAGUGAUGU,
(SEQ ID NO 451)
GUUAAGCGUGUCUGUAUUU,
(SEQ ID NO 452)
GUACAUAUUUGAGACUAGU,
(SEQ ID NO 453)
GACAGCAUAUCAGAGCUUU,
(SEQ ID NO 454)
GUGCAACCCUUACCCCUUA,
(SEQ ID NO 455)
GGGUAGGGCUGACUAGAAG,
(SEQ ID NO 456)
GCUUUGAACAGGAUACUUU,
(SEQ ID NO 457)
CCUACAAGCUUUCCCAGAA,
(SEQ ID NO 458)
GAAAGGGAGCUAUCAGGAA,
(SEQ ID NO 459)
GAAUUUAUCACACUUCUGU,
(SEQ ID NO 460)
GAGAAUCACUAACCAGAGA,
(SEQ ID NO 461)
CCAGGGAGCUUGAAAGUUU,
(SEQ ID NO 462)
CAACUGGGCCCAAGACAGA,
(SEQ ID NO 463)
and
AAGCGUGUCUGUAUUUAUG.
(SEQ ID NO 464)
2 . An siRNA comprising a sense region and an antisense region, wherein said sense region and said antisense region are at least 90% complementary, said sense region and said antisense region together form a duplex region comprising 18-30 base pairs, and said sense region comprises a sequence that is identical to a contiguous stretch of at least 18 bases of a sequence selected from the group consisting of:
AAAGUGCAGUUCAGUAAUA,
(SEQ ID NO 438)
GGAAAUGACCAGACACUGA,
(SEQ ID NO 439)
GGAUACAGCUGGAGUCAGU,
(SEQ ID NO 440)
GAGACUAGAUUGCCUUUGU,
(SEQ ID NO 441)
GAGCCCAUCCCUAUUAUAA,
(SEQ ID NO 442)
GGAGGGCCCUACCUGAUUG,
(SEQ ID NO 443)
GCUCUCUGCUGUACAUAUU,
(SEQ ID NO 444)
GGAGGCAGGCGACGAGUUU,
(SEQ ID NO 445)
AAAGGAGGCUGGCAGGUAU,
(SEQ ID NO 446)
CCAGAAAGGAGACUAGAUU,
(SEQ ID NO 447)
GUUGAGCCCAUCCCUAUUA,
(SEQ ID NO 448)
CAAAGGAGGCUGGCAGGUA,
(SEQ ID NO 449)
GUCCAAAUGUCCUCCAGAA,
(SEQ ID NO 450)
GGAGUCAGUUUAGUGAUGU,
(SEQ ID NO 451)
GUUAAGCGUGUCUGUAUUU,
(SEQ ID NO 452)
GUACAUAUUUGAGACUAGU,
(SEQ ID NO 453)
GACAGCAUAUCAGAGCUUU,
(SEQ ID NO 454)
GUGCAACCCUUACCCCUUA,
(SEQ ID NO 455)
GGGUAGGGCUGACUAGAAG,
(SEQ ID NO 456)
GCUUUGAACAGGAUACUUU,
(SEQ ID NO 457)
CCUACAAGCUUUCCCAGAA,
(SEQ ID NO 458)
GAAAGGGAGCUAUCAGGAA,
(SEQ ID NO 459)
GAAUUUAUCACACUUCUGU,
(SEQ ID NO 460)
GAGAAUCACUAACCAGAGA,
(SEQ ID NO 461)
CCAGGGAGCUUGAAAGUUU,
(SEQ ID NO 462)
CAACUGGGCCCAAGACAGA,
(SEQ ID NO 463)
and
AAGCGUGUCUGUAUUUAUG.
(SEQ ID NO 464)
3 . The siRNA of claim 2 , wherein the duplex region is 19-30 base pairs, and said sense region comprises a sequence that is identical to a sequence selected from the group consisting of:
AAAGUGCAGUUCAGUAAUA,
(SEQ ID NO 438)
GGAAAUGACCAGACACUGA,
(SEQ ID NO 439)
GGAUACAGCUGGAGUCAGU,
(SEQ ID NO 440)
GAGACUAGAUUGCCUUUGU,
(SEQ ID NO 441)
GAGCCCAUCCCUAUUAUAA,
(SEQ ID NO 442)
GGAGGGCCCUACCUGAUUG,
(SEQ ID NO 443)
GCUCUCUGCUGUACAUAUU,
(SEQ ID NO 444)
GGAGGCAGGCGACGAGUUU,
(SEQ ID NO 445)
AAAGGAGGCUGGCAGGUAU,
(SEQ ID NO 446)
CCAGAAAGGAGACUAGAUU,
(SEQ ID NO 447)
GUUGAGCCCAUCCCUAUUA,
(SEQ ID NO 448)
CAAAGGAGGCUGGCAGGUA,
(SEQ ID NO 449)
GUCCAAAUGUCCUCCAGAA,
(SEQ ID NO 450)
GGAGUCAGUUUAGUGAUGU,
(SEQ ID NO 451)
GUUAAGCGUGUCUGUAUUU,
(SEQ ID NO 452)
GUACAUAUUUGAGACUAGU,
(SEQ ID NO 453)
GACAGCAUAUCAGAGCUUU,
(SEQ ID NO 454)
GUGCAACCCUUACCCCUUA,
(SEQ ID NO 455)
GGGUAGGGCUGACUAGAAG,
(SEQ ID NO 456)
GCUUUGAACAGGAUACUUU,
(SEQ ID NO 457)
CCUACAAGCUUUCCCAGAA,
(SEQ ID NO 458)
GAAAGGGAGCUAUCAGGAA,
(SEQ ID NO 459)
GAAUUUAUCACACUUCUGU,
(SEQ ID NO 460)
GAGAAUCACUAACCAGAGA,
(SEQ ID NO 461)
CCAGGGAGCUUGAAAGUUU,
(SEQ ID NO 462)
CAACUGGGCCCAAGACAGA,
(SEQ ID NO 463)
and
AAGCGUGUCUGUAUUUAUG.
(SEQ ID NO 464)
4 . A pool of at least two siRNAs, wherein said pool comprises a first siRNA and a second siRNA, said first siRNA comprises a duplex region of length 18-30 base pairs that has a first sense region that is at least 90% similar to 18 bases of a first sequence selected from the group consisting of:
AAAGUGCAGUUCAGUAAUA,
(SEQ ID NO 438)
GGAAAUGACCAGACACUGA,
(SEQ ID NO 439)
GGAUACAGCUGGAGUCAGU,
(SEQ ID NO 440)
GAGACUAGAUUGCCUUUGU,
(SEQ ID NO 441)
GAGCCCAUCCCUAUUAUAA,
(SEQ ID NO 442)
GGAGGGCCCUACCUGAUUG,
(SEQ ID NO 443)
GCUCUCUGCUGUACAUAUU,
(SEQ ID NO 444)
GGAGGCAGGCGACGAGUUU,
(SEQ ID NO 445)
AAAGGAGGCUGGCAGGUAU,
(SEQ ID NO 446)
CCAGAAAGGAGACUAGAUU,
(SEQ ID NO 447)
GUUGAGCCCAUCCCUAUUA,
(SEQ ID NO 448)
CAAAGGAGGCUGGCAGGUA,
(SEQ ID NO 449)
GUCCAAAUGUCCUCCAGAA,
(SEQ ID NO 450)
GGAGUCAGUUUAGUGAUGU,
(SEQ ID NO 451)
GUUAAGCGUGUCUGUAUUU,
(SEQ ID NO 452)
GUACAUAUUUGAGACUAGU,
(SEQ ID NO 453)
GACAGCAUAUCAGAGCUUU,
(SEQ ID NO 454)
GUGCAACCCUUACCCCUUA,
(SEQ ID NO 455)
GGGUAGGGCUGACUAGAAG,
(SEQ ID NO 456)
GCUUUGAACAGGAUACUUU,
(SEQ ID NO 457)
CCUACAAGCUUUCCCAGAA,
(SEQ ID NO 458)
GAAAGGGAGCUAUCAGGAA,
(SEQ ID NO 459)
GAAUUUAUCACACUUCUGU,
(SEQ ID NO 460)
GAGAAUCACUAACCAGAGA,
(SEQ ID NO 461)
CCAGGGAGCUUGAAAGUUU,
(SEQ ID NO 462)
CAACUGGGCCCAAGACAGA,
(SEQ ID NO 463)
and
AAGCGUGUCUGUAUUUAUG,
(SEQ ID NO 464)
and
said second siRNA comprises a duplex region of length 18-30 base pairs that has a second sense region that is at least 90% similar to 18 bases of a second sequence selected from the group consisting of:
AAAGUGCAGUUCAGUAAUA,
(SEQ ID NO 438)
GGAAAUGACCAGACACUGA,
(SEQ ID NO 439)
GGAUACAGCUGGAGUCAGU,
(SEQ ID NO 440)
GAGACUAGAUUGCCUUUGU,
(SEQ ID NO 441)
GAGCCCAUCCCUAUUAUAA,
(SEQ ID NO 442)
GGAGGGCCCUACCUGAUUG,
(SEQ ID NO 443)
GCUCUCUGCUGUACAUAUU,
(SEQ ID NO 444)
GGAGGCAGGCGACGAGUUU,
(SEQ ID NO 445)
AAAGGAGGCUGGCAGGUAU,
(SEQ ID NO 446)
CCAGAAAGGAGACUAGAUU,
(SEQ ID NO 447)
GUUGAGCCCAUCCCUAUUA,
(SEQ ID NO 448)
CAAAGGAGGCUGGCAGGUA,
(SEQ ID NO 449)
GUCCAAAUGUCCUCCAGAA,
(SEQ ID NO 450)
GGAGUCAGUUUAGUGAUGU,
(SEQ ID NO 451)
GUUAAGCGUGUCUGUAUUU,
(SEQ ID NO 452)
GUACAUAUUUGAGACUAGU,
(SEQ ID NO 453)
GACAGCAUAUCAGAGCUUU,
(SEQ ID NO 454)
GUGCAACCCUUACCCCUUA,
(SEQ ID NO 455)
GGGUAGGGCUGACUAGAAG,
(SEQ ID NO 456)
GCUUUGAACAGGAUACUUU,
(SEQ ID NO 457)
CCUACAAGCUUUCCCAGAA,
(SEQ ID NO 458)
GAAAGGGAGCUAUCAGGAA,
(SEQ ID NO 459)
GAAUUUAUCACACUUCUGU,
(SEQ ID NO 460)
GAGAAUCACUAACCAGAGA,
(SEQ ID NO 461)
CCAGGGAGCUUGAAAGUUU,
(SEQ ID NO 462)
CAACUGGGCCCAAGACAGA,
(SEQ ID NO 463)
and
AAGCGUGUCUGUAUUUAUG,
(SEQ ID NO 464)
and
wherein said first sense region and said second sense region are not identical.
5 . The pool of claim 4 , wherein said first sense region comprises a sequence that is identical to at least 18 bases of a sequence selected from the group consisting of:
AAAGUGCAGUUCAGUAAUA,
(SEQ ID NO 438)
GGAAAUGACCAGACACUGA,
(SEQ ID NO 439)
GGAUACAGCUGGAGUCAGU,
(SEQ ID NO 440)
GAGACUAGAUUGCCUUUGU,
(SEQ ID NO 441)
GAGCCCAUCCCUAUUAUAA,
(SEQ ID NO 442)
GGAGGGCCCUACCUGAUUG,
(SEQ ID NO 443)
GCUCUCUGCUGUACAUAUU,
(SEQ ID NO 444)
GGAGGCAGGCGACGAGUUU,
(SEQ ID NO 445)
AAAGGAGGCUGGCAGGUAU,
(SEQ ID NO 446)
CCAGAAAGGAGACUAGAUU,
(SEQ ID NO 447)
GUUGAGCCCAUCCCUAUUA,
(SEQ ID NO 448)
CAAAGGAGGCUGGCAGGUA,
(SEQ ID NO 449)
GUCCAAAUGUCCUCCAGAA,
(SEQ ID NO 450)
GGAGUCAGUUUAGUGAUGU,
(SEQ ID NO 451)
GUUAAGCGUGUCUGUAUUU,
(SEQ ID NO 452)
GUACAUAUUUGAGACUAGU,
(SEQ ID NO 453)
GACAGCAUAUCAGAGCUUU,
(SEQ ID NO 454)
GUGCAACCCUUACCCCUUA,
(SEQ ID NO 455)
GGGUAGGGCUGACUAGAAG,
(SEQ ID NO 456)
GCUUUGAACAGGAUACUUU,
(SEQ ID NO 457)
CCUACAAGCUUUCCCAGAA,
(SEQ ID NO 458)
GAAAGGGAGCUAUCAGGAA,
(SEQ ID NO 459)
GAAUUUAUCACACUUCUGU,
(SEQ ID NO 460)
GAGAAUCACUAACCAGAGA,
(SEQ ID NO 461)
CCAGGGAGCUUGAAAGUUU,
(SEQ ID NO 462)
CAACUGGGCCCAAGACAGA,
(SEQ ID NO 463)
and
AAGCGUGUCUGUAUUUAUG,
(SEQ ID NO 464)
and
said second sense region comprises a sequence that is identical to at least 18 bases of a sequence selected from the group consisting of:
AAAGUGCAGUUCAGUAAUA,
(SEQ ID NO 438)
GGAAAUGACCAGACACUGA,
(SEQ ID NO 439)
GGAUACAGCUGGAGUCAGU,
(SEQ ID NO 440)
GAGACUAGAUUGCCUUUGU,
(SEQ ID NO 441)
GAGCCCAUCCCUAUUAUAA,
(SEQ ID NO 442)
GGAGGGCCCUACCUGAUUG,
(SEQ ID NO 443)
GCUCUCUGCUGUACAUAUU,
(SEQ ID NO 444)
GGAGGCAGGCGACGAGUUU,
(SEQ ID NO 445)
AAAGGAGGCUGGCAGGUAU,
(SEQ ID NO 446)
CCAGAAAGGAGACUAGAUU,
(SEQ ID NO 447)
GUUGAGCCCAUCCCUAUUA,
(SEQ ID NO 448)
CAAAGGAGGCUGGCAGGUA,
(SEQ ID NO 449)
GUCCAAAUGUCCUCCAGAA,
(SEQ ID NO 450)
GGAGUCAGUUUAGUGAUGU,
(SEQ ID NO 451)
GUUAAGCGUGUCUGUAUUU,
(SEQ ID NO 452)
GUACAUAUUUGAGACUAGU,
(SEQ ID NO 453)
GACAGCAUAUCAGAGCUUU,
(SEQ ID NO 454)
GUGCAACCCUUACCCCUUA,
(SEQ ID NO 455)
GGGUAGGGCUGACUAGAAG,
(SEQ ID NO 456)
GCUUUGAACAGGAUACUUU,
(SEQ ID NO 457)
CCUACAAGCUUUCCCAGAA,
(SEQ ID NO 458)
GAAAGGGAGCUAUCAGGAA,
(SEQ ID NO 459)
GAAUUUAUCACACUUCUGU,
(SEQ ID NO 460)
GAGAAUCACUAACCAGAGA,
(SEQ ID NO 461)
CCAGGGAGCUUGAAAGUUU,
(SEQ ID NO 462)
CAACUGGGCCCAAGACAGA,
(SEQ ID NO 463)
and
AAGCGUGUCUGUAUUUAUG.
(SEQ ID NO 464)
6 . The pool of claim 4 , wherein said duplex of said first siRNA is 19-30 base pairs and said first sense region comprises a sequence that is at least 90% similar to a sequence selected from the group consisting of:
AAAGUGCAGUUCAGUAAUA,
(SEQ ID NO 438)
GGAAAUGACCAGACACUGA,
(SEQ ID NO 439)
GGAUACAGCUGGAGUCAGU,
(SEQ ID NO 440)
GAGACUAGAUUGCCUUUGU,
(SEQ ID NO 441)
GAGCCCAUCCCUAUUAUAA,
(SEQ ID NO 442)
GGAGGGCCCUACCUGAUUG,
(SEQ ID NO 443)
GCUCUCUGCUGUACAUAUU,
(SEQ ID NO 444)
GGAGGCAGGCGACGAGUUU,
(SEQ ID NO 445)
AAAGGAGGCUGGCAGGUAU,
(SEQ ID NO 446)
CCAGAAAGGAGACUAGAUU,
(SEQ ID NO 447)
GUUGAGCCCAUCCCUAUUA,
(SEQ ID NO 448)
CAAAGGAGGCUGGCAGGUA,
(SEQ ID NO 449)
GUCCAAAUGUCCUCCAGAA,
(SEQ ID NO 450)
GGAGUCAGUUUAGUGAUGU,
(SEQ ID NO 451)
GUUAAGCGUGUCUGUAUUU,
(SEQ ID NO 452)
GUACAUAUUUGAGACUAGU,
(SEQ ID NO 453)
GACAGCAUAUCAGAGCUUU,
(SEQ ID NO 454)
GUGCAACCCUUACCCCUUA,
(SEQ ID NO 455)
GGGUAGGGCUGACUAGAAG,
(SEQ ID NO 456)
GCUUUGAACAGGAUACUUU,
(SEQ ID NO 457)
CCUACAAGCUUUCCCAGAA,
(SEQ ID NO 458)
GAAAGGGAGCUAUCAGGAA,
(SEQ ID NO 459)
GAAUUUAUCACACUUCUGU,
(SEQ ID NO 460)
GAGAAUCACUAACCAGAGA,
(SEQ ID NO 461)
CCAGGGAGCUUGAAAGUUU,
(SEQ ID NO 462)
CAACUGGGCCCAAGACAGA,
(SEQ ID NO 463)
and
AAGCGUGUCUGUAUUUAUG,
(SEQ ID NO 464)
and
said duplex of said second siRNA is 19-30 base pairs and comprises a sequence that is at least 90% similar to a sequence selected from the group consisting of:
AAAGUGCAGUUCAGUAAUA,
(SEQ ID NO 438)
GGAAAUGACCAGACACUGA,
(SEQ ID NO 439)
GGAUACAGCUGGAGUCAGU,
(SEQ ID NO 440)
GAGACUAGAUUGCCUUUGU,
(SEQ ID NO 441)
GAGCCCAUCCCUAUUAUAA,
(SEQ ID NO 442)
GGAGGGCCCUACCUGAUUG,
(SEQ ID NO 443)
GCUCUCUGCUGUACAUAUU,
(SEQ ID NO 444)
GGAGGCAGGCGACGAGUUU,
(SEQ ID NO 445)
AAAGGAGGCUGGCAGGUAU,
(SEQ ID NO 446)
CCAGAAAGGAGACUAGAUU,
(SEQ ID NO 447)
GUUGAGCCCAUCCCUAUUA,
(SEQ ID NO 448)
CAAAGGAGGCUGGCAGGUA,
(SEQ ID NO 449)
GUCCAAAUGUCCUCCAGAA,
(SEQ ID NO 450)
GGAGUCAGUUUAGUGAUGU,
(SEQ ID NO 451)
GUUAAGCGUGUCUGUAUUU,
(SEQ ID NO 452)
GUACAUAUUUGAGACUAGU,
(SEQ ID NO 453)
GACAGCAUAUCAGAGCUUU,
(SEQ ID NO 454)
GUGCAACCCUUACCCCUUA,
(SEQ ID NO 455)
GGGUAGGGCUGACUAGAAG,
(SEQ ID NO 456)
GCUUUGAACAGGAUACUUU,
(SEQ ID NO 457)
CCUACAAGCUUUCCCAGAA,
(SEQ ID NO 458)
GAAAGGGAGCUAUCAGGAA,
(SEQ ID NO 459)
GAAUUUAUCACACUUCUGU,
(SEQ ID NO 460)
GAGAAUCACUAACCAGAGA,
(SEQ ID NO 461)
CCAGGGAGCUUGAAAGUUU,
(SEQ ID NO 462)
CAACUGGGCCCAAGACAGA,
(SEQ ID NO 463)
and
AAGCGUGUCUGUAUUUAUG.
(SEQ ID NO 464)
7 . The pool of claim 4 , wherein said duplex of said first siRNA is 19-30 base pairs and said first sense region comprises a sequence that is identical to at least 18 bases of a sequence selected the group consisting of:
AAAGUGCAGUUCAGUAAUA,
(SEQ ID NO 438)
GGAAAUGACCAGACACUGA,
(SEQ ID NO 439)
GGAUACAGCUGGAGUCAGU,
(SEQ ID NO 440)
GAGACUAGAUUGCCUUUGU,
(SEQ ID NO 441)
GAGCCCAUCCCUAUUAUAA,
(SEQ ID NO 442)
GGAGGGCCCUACCUGAUUG,
(SEQ ID NO 443)
GCUCUCUGCUGUACAUAUU,
(SEQ ID NO 444)
GGAGGCAGGCGACGAGUUU,
(SEQ ID NO 445)
AAAGGAGGCUGGCAGGUAU,
(SEQ ID NO 446)
CCAGAAAGGAGACUAGAUU,
(SEQ ID NO 447)
GUUGAGCCCAUCCCUAUUA,
(SEQ ID NO 448)
CAAAGGAGGCUGGCAGGUA,
(SEQ ID NO 449)
GUCCAAAUGUCCUCCAGAA,
(SEQ ID NO 450)
GGAGUCAGUUUAGUGAUGU,
(SEQ ID NO 451)
GUUAAGCGUGUCUGUAUUU,
(SEQ ID NO 452)
GUACAUAUUUGAGACUAGU,
(SEQ ID NO 453)
GACAGCAUAUCAGAGCUUU,
(SEQ ID NO 454)
GUGCAACCCUUACCCCUUA,
(SEQ ID NO 455)
GGGUAGGGCUGACUAGAAG,
(SEQ ID NO 456)
GCUUUGAACAGGAUACUUU,
(SEQ ID NO 457)
CCUACAAGCUUUCCCAGAA,
(SEQ ID NO 458)
GAAAGGGAGCUAUCAGGAA,
(SEQ ID NO 459)
GAAUUUAUCACACUUCUGU,
(SEQ ID NO 460)
GAGAAUCACUAACCAGAGA,
(SEQ ID NO 461)
CCAGGGAGCUUGAAAGUUU,
(SEQ ID NO 462)
CAACUGGGCCCAAGACAGA,
(SEQ ID NO 463)
and
AAGCGUGUCUGUAUUUAUG,
(SEQ ID NO 464)
and
said duplex of said second siRNA is 19-30 base pairs and said second sense region comprises a sequence that is identical to a sequence selected from the group consisting of:
AAAGUGCAGUUCAGUAAUA,
(SEQ ID NO 438)
GGAAAUGACCAGACACUGA,
(SEQ ID NO 439)
GGAUACAGCUGGAGUCAGU,
(SEQ ID NO 440)
GAGACUAGAUUGCCUUUGU,
(SEQ ID NO 441)
GAGCCCAUCCCUAUUAUAA,
(SEQ ID NO 442)
GGAGGGCCCUACCUGAUUG,
(SEQ ID NO 443)
GCUCUCUGCUGUACAUAUU,
(SEQ ID NO 444)
GGAGGCAGGCGACGAGUUU,
(SEQ ID NO 445)
AAAGGAGGCUGGCAGGUAU,
(SEQ ID NO 446)
CCAGAAAGGAGACUAGAUU,
(SEQ ID NO 447)
GUUGAGCCCAUCCCUAUUA,
(SEQ ID NO 448)
CAAAGGAGGCUGGCAGGUA,
(SEQ ID NO 449)
GUCCAAAUGUCCUCCAGAA,
(SEQ ID NO 450)
GGAGUCAGUUUAGUGAUGU,
(SEQ ID NO 451)
GUUAAGCGUGUCUGUAUUU,
(SEQ ID NO 452)
GUACAUAUUUGAGACUAGU,
(SEQ ID NO 453)
GACAGCAUAUCAGAGCUUU,
(SEQ ID NO 454)
GUGCAACCCUUACCCCUUA,
(SEQ ID NO 455)
GGGUAGGGCUGACUAGAAG,
(SEQ ID NO 456)
GCUUUGAACAGGAUACUUU,
(SEQ ID NO 457)
CCUACAAGCUUUCCCAGAA,
(SEQ ID NO 458)
GAAAGGGAGCUAUCAGGAA,
(SEQ ID NO 459)
GAAUUUAUCACACUUCUGU,
(SEQ ID NO 460)
GAGAAUCACUAACCAGAGA,
(SEQ ID NO 461)
CCAGGGAGCUUGAAAGUUU,
(SEQ ID NO 462)
CAACUGGGCCCAAGACAGA,
(SEQ ID NO 463)
and
AAGCGUGUCUGUAUUUAUG.
(SEQ ID NO 464)Join the waitlist — get patent alerts
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