US2010150933A1PendingUtilityA1

Cytokine antagonists for neurological and neuropsychiatric disorders

Individually held — no corporate assignee on recordPriority: Feb 24, 1999Filed: Feb 26, 2010Published: Jun 17, 2010
Est. expiryFeb 24, 2019(expired)· nominal 20-yr term from priority
A61K 39/3955C07K 16/241C07K 2319/32A61P 25/24A61P 25/30A61P 25/06A61K 47/6835A61P 25/28A61P 25/18A61P 25/00A61K 38/1793A61K 2039/505A61K 47/60A61P 25/34A61K 38/20C07K 2319/30A61P 25/16A61K 47/6811A61K 9/0019
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Claims

Abstract

A method of treating a nerve disorder mediated by nucleus pulposus in a mammal in need thereof, comprising: administering to said mammal a TNF-α inhibitor that is a monoclonal antibody which blocks TNF-α activity, thereby inhibiting TNF-α and treating said disorder.

Claims

exact text as granted — not AI-modified
1 - 59 . (canceled) 
     
     
         60 . A method of treating a nerve disorder mediated by nucleus pulposus in a mammal in need thereof, comprising:
 administering to said mammal a TNF-α inhibitor that is a monoclonal antibody which blocks TNF-α activity, thereby inhibiting TNF-α and treating said disorder.   
     
     
         61 . The method of  claim 60 , wherein said nerve disorder presents as sciatica. 
     
     
         62 . The method of  claim 60 , wherein said nerve disorder involves pain. 
     
     
         63 . The method of  claim 60 , wherein said nerve disorder is caused by a herniated disc. 
     
     
         64 . The method of  claim 60 , wherein said nerve disorder is nerve root injury. 
     
     
         65 . The method of  claim 60 , wherein the mammal is human. 
     
     
         66 . The method of  claim 60 , wherein said TNF-α inhibitor is administered parenterally. 
     
     
         67 . The method of  claim 60 , wherein said TNF-α inhibitor is administered intramuscularly or subcutaneously.

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