Medicinal composition, food or drink having effect of enhancing sympathetic nervous activity

Abstract

It is intended to provide a safe composition for preventing or treating obesity or related complications which has an autonomic nervous control effect, in particular, an effect of enhancing sympathetic nervous activity and an effect of promoting energy metabolism. Thus, a medicinal composition, a food or a drink containing 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and having an autonomic nervous control effect and an effect of promoting energy metabolism is provided.

1 . A medicinal composition, a food or a drink which contains a clinically effective amount of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and a pharmaceutically or nutritionally acceptable additive and has an autonomic nervous control effect. 
   
   
       2 . A medicinal composition, food or drink as claimed in  claim 1  wherein the autonomic nervous control effect is an effect of enhancing sympathetic nervous activity. 
   
   
       3 . A medicinal composition, food or drink as claimed in  claim 1  which has an effect of promoting energy metabolism. 
   
   
       4 . A medicinal composition, food or drink as claimed in  claim 1  which is to be used for treating a disease or condition relating to autonomic nervous activity or energy metabolism. 
   
   
       5 . A medicinal composition, food or drink as claimed in  claim 4  wherein the disease or condition relating to autonomic nervous activity or energy metabolism is obesity and/or related complications. 
   
   
       6 . A medicinal composition, food or drink as claimed in  claim 1  which contains a microorganism capable of producing 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one or a processed product thereof. 
   
   
       7 . A medicinal composition, food or drink as claimed in  claim 1  which contains a culture supernatant of a microorganism capable of producing 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one or a processed product thereof. 
   
   
       8 . A medicinal composition, food or drink as claimed in  claim 6  wherein the microorganism is a lactic acid bacterium. 
   
   
       9 . A medicinal composition, food or drink as claimed in  claim 8  wherein the lactic acid bacterium is one belonging to the genus  Streptococcus, Lactobacillus, Leuconostoc, Pediococcus, Bifidobacterium, Tetragenococcus, Weissella, Enterococcus, Melisscoccus, Lactococcus, Carnobacterium, Vagococcus, Atopobium, Lactosphaera, Oenococcus, Abiotrophia, Paralactobacillus, Granulicatella, Atopobactor, Alkalibacterium  or  Olsenella.    
   
   
       10 . A medicinal composition, food or drink as claimed in  claim 6  wherein the microorganism belongs to  Lactobacillus plantarum  (preferably  Lactobacillus plantarum  SAM 2446 strain (FERM BP-10438)) or  Lactobacillus brevis  (preferably  Lactobacillus brevis  SAM 2447 strain (FERM BP-10439)). 
   
   
       11 . A method of producing a medicinal composition, food or drink as claimed in  claim 1  which comprises the step of culturing a microorganism capable of producing 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one in a medium.