US2010144895A1PendingUtilityA1

Embolic compositions with non-cyanoacrylate rheology modifying agents

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Assignee: BOSTON SCIENT SCIMED INCPriority: Aug 20, 2001Filed: Feb 17, 2010Published: Jun 10, 2010
Est. expiryAug 20, 2021(expired)· nominal 20-yr term from priority
Inventors:Stephen Porter
A61L 2430/36C08F 20/32A61L 24/06
49
PatentIndex Score
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Claims

Abstract

Compositions for embolization are disclosed herein. The compositions disclosed can have a matrix-forming component, a solid-aggregate material, and a rheology modifying agent, wherein the matrix-forming component includes at least alkyl cyanoacrylate monomers, a stabilizer, and a plasticizer, and the solid-aggregate material includes at least a radiopacifier. The composition and a method of administering the composition are useful for treating vasculature abnormalities, particularly when the composition solidifies upon contact with an ionic environment, such as blood.

Claims

exact text as granted — not AI-modified
1 . A composition comprising:
 a matrix-forming component comprising alkyl cyanoacrylate monomers, a stabilizer, and a plasticizer;   a solid aggregate material comprising a radiopacifier; and   a polymeric non-cyanoacrylate rheology modifying agent.   
     
     
         2 - 3 . (canceled) 
     
     
         4 . The composition of  claim 1 , wherein the polymeric non-cyanoacrylate rheology modifying agent is a polymer or copolymer compound soluble in the alkyl cyanoacrylate monomers or in the plasticizer. 
     
     
         5 . The composition of  claim 1 , wherein the polymeric non-cyanoacrylate rheology modifying agent is selected from the group consisting of poly(acrylates), poly(alkenes), poly(alkyl oxides), poly(amides), poly(carbonates), cellulosic polymers and copolymers, poly(dienes), poly(esters), poly(methacrylates), poly(saccharides), poly(siloxanes), poly(styrenes), poly(urethanes), poly(vinyl ethers), poly(vinyl esters), polymers and copolymers having high iodine content, and mixtures thereof. 
     
     
         6 . (canceled) 
     
     
         7 . The composition of  claim 1 , wherein the polymeric non-cyanoacrylate rheology modifying agent has a molecular weight of at least 75,000. 
     
     
         8 . The composition of  claim 1 , wherein the polymeric non-cyanoacrylate rheology modifying agent has a molecular weight of at least 200,000. 
     
     
         9 . The composition of  claim 1 , wherein the polymeric non-cyanoacrylate rheology modifying agent and the plasticizer is the same material. 
     
     
         10 . The composition of  claim 1 , wherein the polymeric non-cyanoacrylate rheology modifying agent comprises up to about 10%, by weight of the matrix-forming components. 
     
     
         11 . The composition of  claim 1 , wherein the polymeric non-cyanoacrylate rheology modifying agent comprises about 1% to about 5%, by weight of the matrix-forming components. 
     
     
         12 . The composition of  claim 1 , wherein the polymeric non-cyanoacrylate rheology modifying agent is a particulate material comprising about 0% to about 75% by volume of the solid-aggregate materials. 
     
     
         13 . The composition of  claim 1 , wherein the polymeric non-cyanoacrylate rheology modifying agent is a particulate material comprising about 0% to about 40%, by volume of the solid-aggregate materials. 
     
     
         14 . The composition of  claim 1 , wherein the polymeric non-cyanoacrylate rheology modifying agent comprises inorganic particles with surface-modifying molecules adsorbed to or bonded to the surfaces of said particles for improving the stability of a suspension of said particles within said composition. 
     
     
         15 . The composition of  claim 1 , wherein the alkyl cyanoacrylate monomer is a compound of the formula H 2 C═C(CN)—C(O)OR, wherein R is an alkyl group of about 1 to about 18 carbons. 
     
     
         16 . The composition of  claim 15 , wherein the group represented by R is an alkyl group of about 4 to about 10 carbons. 
     
     
         17 . The composition of  claim 1 , wherein the alkyl cyanoacrylate monomer is present in an amount of from about 20% to about 75%, by weight of the matrix-forming component. 
     
     
         18 . The composition of  claim 1 , wherein the alkyl cyanoacrylate monomer is present in an amount of from about 30% to about 70%, by weight of the matrix-forming component. 
     
     
         19 . The composition of  claim 1 , wherein the stabilizer is an inorganic acid, an organic acid, a free radical inhibitor, an antioxidant, or a mixture thereof. 
     
     
         20 . The composition of  claim 1 , wherein the stabilizer is present in an amount of from about 50 ppm to about 500 ppm. 
     
     
         21 . The composition of  claim 1 , wherein the radiopacifier is selected from the group consisting of Ta, TaO, Au, Pt, Zr, ZrO, bismuth subcarbonate, and barium sulfate. 
     
     
         22 . The composition of  claim 1 , wherein the radiopacifier comprises radio-opaque particles with surface-modifying molecules adsorbed to or bonded to the surfaces of said particles for improving the stability of a suspension of said particles within said composition. 
     
     
         23 . The composition of  claim 1 , wherein the radiopacifier is about 25% to about 100%, by volume of the solid-aggregate material. 
     
     
         24 . The composition of  claim 1 , wherein the radiopacifier is about 60% to about 100%, by volume of the solid-aggregate material. 
     
     
         25 . The composition of  claim 1 , wherein the plasticizer is selected from the group consisting of organic esters containing 10 or more carbon atoms and polymeric compounds, having a glass transition temperature less than 20° C. 
     
     
         26 . The composition of  claim 1 , wherein the plasticizer is selected from the group consisting of aromatic esters, alkyl esters, phthalate esters, citrate esters, glycerol esters, plant derived oils, animal derived oils, silicone oils, iodinated oils, vitamins A, C, E, and acetates and esters thereof, and mixtures thereof. 
     
     
         27 . The composition of  claim 1 , wherein the plasticizer is about 10% to about 75%, by weight of the matrix-forming component. 
     
     
         28 . The composition of  claim 1 , wherein the plasticizer is about 30% to about 60%, by weight of the matrix-forming component. 
     
     
         29 - 37 . (canceled)

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