Antimicrobial compositions

Abstract

Antimicrobial compositions and methods are disclosed. The antimicrobial compositions are particularly useful in providing antimicrobial capability to a wide-range of medical devices. In one aspect the invention relates a UV curable antimicrobial coating comprising a UV curable composition comprising an oligomer, a momoner, and a photoinitiator which are together capable of forming a UV curable polymer composition. The compositions include rheology modifiers as necessary. The compositions also include antimicrobial agents, which may be selected from a wide array of agents. Representative antimicrobial agents include cetyl pyridium chloride, cetrimide, alexidine, chlorexidine diacetate, benzalkonium chloride, and o-phthalaldehyde.

1 . An antimicrobial ultraviolet (UV) curable coating comprising:
 a UV curable composition comprising an oligomer, a momoner, and a photo initiator;   a rheology modifier; and   an antimicrobial agent.   
     
     
         2 . The antimicrobial UV curable coating of  claim 1  wherein the oligomer is selected from the group consisting of acrylated aliphatic urethanes, acrylated aromatic urethanes, acrylated polyesters, unsaturated polyesters, acrylated polyethers, and acrylated acrylics. 
     
     
         3 . The antimicrobial UV curable coating of  claim 2  wherein the acrylated functional group is selected from the group consisting of mono-functional, di-functional, tri-functional, tetra-functional, penta-functional, and hexa-functional acrylates. 
     
     
         4 . The antimicrobial UV curable coating of  claim 1  wherein the monomer is selected from the group consisting of 2-ethyl hexyl acrylate, isooctyl acrylate, isobornylacrylate, 1,6-hexanediol diacrylate, diethylene glycol diacrylate, triethylene glycol diacrylate, pentaerythritol tetra acrylate, penta erythritol tri acrylate, dimethoxy phenyl acetophenone hexyl methyl acrylate, and 1,6 hexanidiol methacrylate, 
     
     
         5 . The antimicrobial UV curable coating of  claim 1  wherein the photoinitiator is selected from the group consisting of benzoin ethers, acetophenones, benzoyl oximes, acyl phosphine oxide, and Michler's ketone, thioxanthone, anthroguionone, benzophenone, methyl diethanol amine, and 2-N-butoxyethyl-4-(dimethylamino)benzoate. 
     
     
         6 . The antimicrobial UV curable coating of  claim 1  wherein the rheological modifier is selected from the group consisting of organic clay, castor wax, polyamide wax, polyurethane, and fumed silica. 
     
     
         7 . The antimicrobial UV curable coating of  claim 1  wherein the Theological modifier is fumed silica. 
     
     
         8 . The antimicrobial UV curable coating of  claim 1  wherein the antimicrobial agent is selected from the group consisting of aldehydes, anilides, biguanides, silver, silver compound, bis-phenols, and quaternary ammonium compounds. 
     
     
         9 . The antimicrobial UV coating of  claim 1  wherein the antimicrobial agent is selected from the group consisting of cetrimide and cetyl pyridium chloride. 
     
     
         10 . The antimicrobial UV coating of  claim 1  wherein the antimicrobial agent is selected from the group consisting of chlorhexidine diacetate, alexidine, and benzalkonium chloride. 
     
     
         11 . The antimicrobial UV curable coating of  claim 1  wherein the composition comprises rheological modifier in the amount of from about 0.1 to about 30 parts by weight in 100 parts by weight the UV-curable composition. 
     
     
         12 . The antimicrobial UV curable coating of  claim 1  wherein the composition comprises Theological modifier in the amount of from about 0.2 to about 20 parts by weight in 100 parts by the weight of the UV-curable composition. 
     
     
         13 . The antimicrobial UV curable coating of  claim 1  wherein the composition comprises rheological modifier in the amount of from about 0.2 to about 10 parts by weight in 100 parts by weight of the UV-curable composition. 
     
     
         14 . The antimicrobial UV curable coating of  claim 1  wherein the composition comprises antimicrobial agent in the amount of from about 0.5 to about 50 parts by weight in 100 parts by weight of the UV-curable composition. 
     
     
         15 . The antimicrobial UV curable coating of  claim 1  wherein the composition comprises antimicrobial agent in the amount of from about 0.5 to about 30 parts by weight in 100 parts by weight of the UV-curable composition. 
     
     
         16 . The antimicrobial UV curable coating of  claim 1  wherein the composition comprises antimicrobial agent in the amount of from about 0.5 to about 20 parts by weight in 100 parts by weight of the UV-curable composition. 
     
     
         17 . A UV curable coating composition comprising:
 a) a UV curable composition, having;
 from about 10% to about 90% by weight oligomer selected from the group consisting of acrylated aliphatic urethanes, acrylated aromatic urethanes, acrylated polyesters, unsaturated polyesters, acrylated polyethers, and acrylated acrylics; 
 from about 5% to about 90% by weight monomer selected from the group consisting of 2-ethyl hexyl acrylate, isooctyl acrylate, isobornylacrylate, 1,6-hexanediol diacrylate, diethylene glycol diacrylate, triethylene glycol diacrylate, pentaerythritol tetra acrylate, penta erythritol tri acrylate, dimethoxy phenyl acetophenone hexyl methyl acrylate, and 1,6 hexanidiol methacrylate; 
   b) from about 0.1 to about 30 parts by weight rheology modifier in 100 parts UV curable composition, the rheology modifier selected from the group consisting of organic clay, castor wax, polyamide wax, polyurethane, and fumed silica;   c) from about 0.5 to about 50 parts by weight antimicrobial agent in 100 parts UV curable composition, the antimicrobial agent selected from the group consisting of aldehydes, anilides, biguanides, silver, silver compound, bis-phenols, and quaternary ammonium compounds; and   d) from about 1 to about 10 parts photoinitiator.   
     
     
         18 . An antimicrobial coating comprising:
 a UV curable composition having an oligomer, a monomer, a photoinitiator, a rheology modifier; and   an antimicrobial agent selected from the group consisting of cetrimide, cetyl pyridium chloride, chlorhexidine diactetate, alexidine, and benzalkonium chloride.   
     
     
         19 . The antimicrobial coating of  claim 17  wherein the antimicrobial agent is alexidine. 
     
     
         20 . The antimicrobial coating of  claim 17  wherein the antimicrobial agent is cetrimide and cetyl pyridium chloride. 
     
     
         21 . The antimicrobial coating of  claim 17  wherein the antimicrobial agent is chlorhexidine diacetate. 
     
     
         22 . The antimicrobial coating of  claim 17  wherein the antimicrobial agent is benzalkonium chloride. 
     
     
         23 . The antimicrobial coating of  claim 17  further comprising a rheology modifier comprising fumed silica.