Controlling pests by combining insecticides and transgenic plants by applying directly to leaves and roots

Abstract

The invention relates to a method for controlling pests using a combination of insecticides and transgenic plants and consequently improving the utilization of the production potential of transgenic plants which comprises treating the plant with active compound combinations comprising an active compound from the group of the anthranilamides and at least one further insecticide.

1 . Method for improving the utilization of the production potential of a transgenic plant, comprising treating the plant with an effective amount of a mixture of at least one compound of the formula I 
     
       
         
         
             
             
         
       
     
     where R1 represents chlorine or cyano
 and at least one compound of group II, 
 (1) acetylcholinesterase (AChE) inhibitors, optionally selected from carbamates, alanycarb, aldicarb, aldoxycarb, allyxycarb, aminocarb, bendiocarb, benfuracarb, bufencarb, butacarb, butocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulfan, cloethocarb, dimetilan, ethiofencarb, fenobucarb, fenothiocarb, formetanate, furathiocarb, isoprocarb, metam-sodium, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, promecarb, propoxur, thiodicarb, thiofanox, trimethacarb, XMC, and xylylcarb; or 
 organophosphates, acephate, azamethiphos, azinphos (-methyl, -ethyl), bromophos-ethyl, bromfenvinfos (-methyl), butathiofos, cadusafos, carbophenothion, chlorethoxyfos, chlorfenvinphos, chlormephos, chlorpyrifos (-methyl/-ethyl), coumaphos, cyanofenphos, cyanophos, chlorfenvinphos, demeton-S-methyl, demeton-S-methylsulphon, dialifos, diazinon, dichlofenthion, dichlorvos/DDVP, dicrotophos, dimethoate, dimethylvinphos, dioxabenzofos, disulfoton, EPN, ethion, ethoprophos, etrimfos, famphur, fenamiphos, fenitrothion, fensulfothion, fenthion, flupyrazofos, fonofos, formothion, fosmethilan, fosthiazate, heptenophos, iodofenphos, iprobenfos, isazofos, isofenphos, isopropyl, O-salicylate, isoxathion, malathion, mecarbam, methacrifos, methamidophos, methidathion, mevinphos, monocrotophos, naled, omethoate, oxydemeton-methyl, parathion (-methyl/-ethyl), phenthoate, phorate, phosalone, phosmet, phosphamidon, phosphocarb, phoxim, pirimiphos (-methyl/-ethyl), profenofos, propaphos, propetamphos, prothiofos, prothoate, pyraclofos, pyridaphenthion, pyridathion, quinalphos, sebufos, sulfotep, sulprofos, tebupirimfos, temephos, terbufos, tetra-chlorvinphos, thiometon, triazophos, triclorfon, vamidothion, and imicyafos. 
 (2) GABA-gated chloride channel antagonists, optionally-selected from organochlorines, camphechlor, chlordane, endosulfan, gamma-HCH, HCH, heptachlor, lindane, and methoxychlor; or 
 fiproles (phenylpyrazoles), acetoprole, ethiprole, fipronil, pyrafluprole, pyriprole, and vaniliprole. 
 (3) Sodium channel modulators/voltage-dependent sodium channel blockers, optionally selected from pyrethroids, acrinathrin, allethrin (d-cis-trans, d-trans), beta-cyfluthrin, bifenthrin, bioallethrin, bioallethrin S-cyclopentyl isomer, bioethanomethrin, biopermethrin, bioresmethrin, chlovaporthrin, cis-cypermethrin, cis-resmethrin, cis-permethrin, clocythrin, cycloprothrin, cyfluthrin, cyhalothrin, cypermethrin (alpha-, beta-, theta-, zeta-), cyphenothrin, deltamethrin, empenthrin (1R isomer), esfenvalerate, etofenprox, fenfluthrin, fenpropathrin, fenpyrithrin, fenvalerate, flubrocythrinate, flucythrinate, flufenprox, flumethrin, fluvalinate, fubfenprox, gamma-cyhalothrin, imiprothrin, kadethrin, lambda-cyhalothrin, metofluthrin, permethrin (cis-, trans-), phenothrin (1R trans isomer), prallethrin, profluthrin, protrifenbute, pyresmethrin, resmethrin, RU 15525, silafluofen, tau-fluvalinate, tefluthrin, terallethrin, tetramethrin (-1R-isomer), tralomethrin, transfluthrin, ZXI 8901, pyrethrin (pyrethrum), eflusilanat; DDT; or methoxychlor. 
 (4) Nicotinergic acetylcholine receptor agonists/antagonists, optionally selected from chloronicotinyls, acetamiprid, clothianidin, dinotefuran, imidacloprid, imidaclothiz, nitenpyram, nithiazine, thiacloprid, thiamethoxam, AKD-1022, nicotine, bensultap, cartap, thiosultap-sodium, and thiocylam. 
 (5) Allosteric acetylcholine receptor modulators (agonists), optionally selected from spinosyns, spinosad and spinetoram. 
 (6) Chloride channel activators, optionally selected from mectins/macrolides, abamectin, emamectin, emamectin benzoate, ivermectin, lepimectin, and milbemectin; or 
 juvenile hormone analogues, hydroprene, kinoprene, methoprene, epofenonane, triprene, fenoxycarb, pyriproxifen, and diofenolan. 
 (7) Active compounds with unknown or non-specific mechanisms of action, optionally selected from gassing agents, methyl bromide, chloropicrin and sulfuryl fluoride; selective antifeedants, cryolite, pymetrozine, pyrifluquinazon and flonicamid; or mite growth inhibitors, clofentezine, hexythiazox, etoxazole. 
 (8) Oxidative phosphorylation inhibitors, ATP disruptors, optionally selected from diafenthiuron; 
 organotin compounds, azocyclotin, cyhexatin and fenbutatin oxide; or 
 propargite, tetradifon. 
 (9) Oxidative phoshorylation decouplers acting by interrupting the H proton gradient, optionally selected from chlorfenapyr, binapacryl, dinobuton, dinocap and DNOC. 
 (10) Microbial disruptors of the insect gut membrane, optionally selected from  Bacillus thuringiensis  strains. 
 (11) Chitin biosynthesis inhibitors, optionally selected from benzoylureas, bistrifluoron, chlorfluazuron, diflubenzuron, fluazuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluoron, teflubenzuron or triflumuron. 
 (12) Buprofezin. 
 (13) Moulting disruptors, for example cyromazine. 
 (14) Ecdysone agonists/disruptors, optionally selected from diacylhydrazines, chromafenozide, halofenozide, methoxyfenozide, tebufenozide, and flutenozide; or 
 azadirachtin. 
 (15) Octopaminergic agonists, optionally selected from amitraz. 
 (16) Site III electron transport inhibitors/site II electron transport inhibitors, optionally selected from hydramethylnon; acequinocyl; fluacrypyrim; or cyflumetofen and cyenopyrafen. 
 (17) Electron transport inhibitors, optionally selected from site I electron transport inhibitors, from the group of the METI acaricides, fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad, and rotenone; or 
 voltage-dependent sodium channel blockers, indoxacarb and metaflumizone. 
 (18) Fatty acid biosynthesis inhibitors, optionally selected from tetronic acid derivatives, spirodiclofen and spiromesifen; or 
 tetramic acid derivatives, e.g. spirotetramat. 
 (19) Neuronal inhibitors with unknown mechanism of action, bifenazate. 
 (20) Ryanodine receptor effectors, for example diamides, flubendiamide or (R),(S)-3-chloro-N 1 -{2-methyl-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}-N 2 -(1-methyl-2-methylsulphonylethyl)phthalamide. 
 (21) Further active compounds with unknown mechanism of action, optionally selected from amidoflumet, benclothiaz, benzoximate, bromopropylate, buprofezin, chinomethionat, chlordimeform, chlorobenzilate, clothiazoben, cycloprene, dicofol, dicyclanil, fenoxacrim, fentrifanil, flubenzimine, flufenerim, flutenzin, gossyplure, japonilure, metoxadiazone, petroleum, potassium oleate, pyridalyl, sulfluramid, tetrasul, triarathene or verbutin; or the following known active compounds: 
 4-{[(6-bromopyrid-3-yl)methyl](2-fluoroethyl)amino}furan-2(5H)-one (known from WO 2007/115644), 4-{[(6-fluoropyrid-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5H)-one, 4-{[(2-chloro-1,3-thiazol-5-yl)methyl](2-fluoroethyl)amino}furan-2(5H)-one, 4-{[(6-chloropyrid-3-yl)methyl](2-fluoroethyl)amino}furan-2(5H)-one, 4-{[(6-chloropyrid-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5H)-one, 4-{[(6-chloro-5-fluoropyrid-3-yl)methyl](methyl)amino}furan-2(5H)-one, 4-{[(5,6-dichloropyrid-3-yl)methyl](2-fluoroethyl)amino}furan-2(5H)-one, 4-{[(6-chloro-5-fluoropyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-one, 4-{[(6-chloropyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-one, 4-{[(6-chloropyrid-3-yl)methyl](methyl)amino}furan-2(5H)-one, [(6-chloropyridin-3-yl)methyl](methyl)oxido-λ 4 -sulfanylidenecyanamide, [1-(6-chloropyridin-3-yl)ethyl](methyl)oxido-λ 4 -sulfanylidenecyanamide and its diastereomers (A) and (B) 
 
     
       
         
         
             
             
         
       
       [(6-trifluoromethylpyridin-3-yl)methyl](methyl)oxido-λ 4 -sulfanylidenecyanamide, or [1-(6-trifluoromethylpyridin-3-yl)ethyl](methyl)oxido-λ 4 -sulfanylidenecyanamide and its diastereomers (C) and (D) 
     
     
       
         
         
             
             
         
       
     
   
   
       2 . Method according to  claim 1 , wherein said mixture comprises at least one compound of formula I and at least one compound of group II, and optionally at least one further active co-component. 
   
   
       3 . Method according to  claim 1 , wherein the plant has at least one genetically modified structure or a tolerance according to Table 1. 
   
   
       4 . Method according to  claim 1 , wherein the plant has at least one modified principle of action according to Table 3. 
   
   
       5 . Method according to  claim 1 , wherein the plant is a transgenic plant according to Table 4. 
   
   
       6 . Method according to  claim 1 , wherein the plant contains at least one genetic modification according to Table 2. 
   
   
       7 . Method according to  claim 1 , wherein the transgenic plant contains at least one gene or a gene fragment coding for a Bt toxin. 
   
   
       8 . Method according to  claim 1 , wherein the transgenic plant comprises at least one herbicide resistance. 
   
   
       9 . Method according to  claim 1 , wherein the transgenic plant is a vegetable plant, maize plant, soya bean plant, cotton plant, tobacco plant, rice plant, rape plant, sugar beet plant, sunflower plant or potato plant. 
   
   
       10 . Method according to  claim 1 , wherein the mixture of at least one compound of formula I and at least one compound of group (II) are used for controlling insects from the order Isoptera, Thysanoptera, Homoptera, Heteroptera, Lepidoptera, Coleoptera, Hymenoptera and/or Diptera. 
   
   
       11 . Method according to  claim 1 , wherein an application rate from 0.1 g/ha to 5.0 kg/ha, employed. 
   
   
       12 . Method of  claim 1 , wherein an application rate from 0.1 g/ha to 5.0 kg/ha, is employed. 
   
   
       13 . Method of  claim 1 , wherein an application rate from 10 g/ha to 500 kg/ha, is employed. 
   
   
       14 . Method of  claim 1 , wherein an application rate from 10 g/ha to 200 kg/ha, is employed.