US2010129797A1PendingUtilityA1

Use of genetic modifications in human gene chk1 which codes for checkpoint kinase 1

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Assignee: RIEMANN KATHRINPriority: Nov 17, 2006Filed: Nov 19, 2007Published: May 27, 2010
Est. expiryNov 17, 2026(~0.3 yrs left)· nominal 20-yr term from priority
Inventors:Kathrin RiemannWinfried Siffert
C12Q 1/6886C12Q 1/6883C12Q 2600/106C12Q 2600/118C12Q 2600/172C12Q 2600/156C12Q 2600/112
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Claims

Abstract

The invention relates to an in vitro method for predicting disease risks, progression of diseases, drug risks, success of treatment and for finding drug targets by looking for one or more genetic modifications in the promoter region of the CHK1 (CHEK1) gene on human chromosome 11q23, the genetic modifications being a substitution thymine for guanine in position -1143 in the promoter of CHK1, of thymine for cytosine in position -1400, a substitution of cytosine for thymine in position -1453 or an insertion of one cytosine in position -1454 and the genetic modifications being detected individually or in any combinations by way of known methods.

Claims

exact text as granted — not AI-modified
1 . An in vitro method for predicting a disease risk, progression of a disease, a drug risk, or success of a treatment, or for finding a drug target, comprising looking for one or more genetic modification in the promoter region of the CHK1 (CHEK1) gene on human chromosome 11q23. 
     
     
         2 . The method according to  claim 1 , comprising looking for a polymorphism (-1143)G>T in a patient sample. 
     
     
         3 . The method according to  claim 1 , comprising looking for a polymorphism (-1400)C>T in a patient sample. 
     
     
         4 . The method according to  claim 1 , comprising looking for a polymorphism (-1453)T>C in a patient sample. 
     
     
         5 . The method according to  claim 1 , comprising looking for a polymorphism (-1154)insC in a patient sample. 
     
     
         6 . The method according to  claim 1 , comprising looking for one, two, three or four of the polymorphisms (-1143)G>T, (-1400)C>T, (-1453)T>C and (-1154)insC in a patient sample. 
     
     
         7 . The method according to  claim 1 , wherein the disease is a cancer. 
     
     
         8 . The method according to  claim 1 , wherein the treatment is one with a cancer therapeutic agent or a physical treatment of cancer. 
     
     
         9 . The method according to  claim 1 , wherein the drug or cancer therapeutic agent is an inhibitor of checkpoint kinase 1.

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