Antibacterial Agents

Abstract

Compounds of formula (II) are antibacterial agents wherein Q represents a radical of the formula: —N(OH)CH(═O) or the formula: —C(═O)NH(OH); R 1 represents hydrogen, C 1 -C 6 alkyl or C 1 -C 6 alkyl substituted by one or more halogen atoms, or, except when Q is a radical of the formula: —N(OH)CH(═O), a hydroxy, C 1 -C 6 alkoxy, C 1 -C 6 alkenyloxy, amino, C 1 -C 6 alkylamino, or di-(C 1 -C 6 alkylamino group; R 2 represents a substituted or unsubstituted C 1 -C 6 alkyl, cycloalkyl(C 1 -C 6 alkyl)- or aryl(C 1 -C 6 alkyl)-group; and A represents a group of formula (IIA), or (IIB) wherein R 4 represents the side chain of a natural or non-natural alpha amino acid, and R 5 and R 6 when taken together with the nitrogen atom to which they are attached form a saturated heterocyclic first ring of 5 to 7 atoms as specified in the description.

1 - 20 . (canceled) 
   
   
       21 . A compound of formula (II), or a pharmaceutically or veterinarily acceptable salt, hydrate or solvate thereof: 
     
       
         
         
             
             
         
       
       wherein 
       Q represents a radical of formula —N(OH)C(═O)H or formula —C(═O)NH(OH); 
       R 1  is hydrogen; 
       R 2  is n-propyl, n-butyl, n-pentyl, benzyl or cyclopentylmethyl, cyclopentylethyl, cyclohexylmethyl, or cyclohexylethyl; 
       A represents a group of formula (IIA) or (IIB) 
     
     
       
         
         
             
             
         
       
       wherein R 4  is tert-butyl, isobutyl, benzyl or methyl; and 
       R 5  and R 6  taken together with the nitrogen atom to which they are attached form a saturated heterocyclic first ring of 5 to 7 atoms OTHER THAN a piperidine-1-yl or piperazin-4-yl ring which is substituted by a substituent of formula —CH 2 Z, —OZ, or —C(═O)Z 
       wherein Z is a phenyl, 3,4 methylenedioxyphenyl, morpholinyl, pyrimidinyl, 1,2,3-thiadiazolyl, 1,4-thiazolyl, benzofuranyl, furanyl, thienyl, pyranyl, purrolyl, pyrazolyl, isozazolyl, or pyridyl ring, which ring being optionally be substituted by
 (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl, 
 phenyl or halophenyl, 
 monocyclic 5 or 6-membered heterocyclic, 
 benzyl 
 hydroxy, phenoxy, or (C-C 6 ) alkoxy, 
 mercapto, or (C 1 -C 6 ) alkylthio, 
 oxo, 
 nitro, 
 —COOH, or —COOR A , 
 —CONH 2 , —CONHR A  or —CONR A R B , 
 —COR A , 
 —NHCOR A , 
 —NH 2 , —NHR A , —NR A R B , 
 
       wherein R A  and R B  are independently a (C 1 -C 6 ) alkyl group. 
     
   
   
       22 . A pharmaceutical or veterinary composition comprising a compound as claimed in claim  1 , together with a pharmaceutically or veterinarily acceptable carrier. 
   
   
       23 . A method of treatment of bacterial infections in humans and non-human mammals, which comprises administering to a subject suffering such infection an antibacterially effective amount of a compound as claimed in claim  1 .