Guided bone regeneration membrane and manufacturing method thereof

Abstract

Disclosed is a guided bone regeneration membrane including a novel mechanism that effectively induces a bone reconstruction ability. The mechanism is provided by forming a bi-layered structure of a first nonwoven fabric layer containing a silicon-releasable calcium carbonate and a poly(lactic acid) as principal components and a second nonwoven fabric layer containing a poly(lactic acid) as a principal component; and coating the first nonwoven fabric layer with an apatite. The guided bone regeneration membrane is available by using a nonwoven fabric manufacturing technique through electrospinning and a simulated body fluid soaking technique.

1 . A guided bone regeneration membrane comprising a bi-layered structure including a first nonwoven fabric layer and a second nonwoven fabric layer, the first nonwoven fabric layer containing a silicon-releasable calcium carbonate and a biodegradable resin as principal components, and the second nonwoven fabric layer containing a biodegradable resin as a principal component. 
     
     
         2 . The guided bone regeneration membrane according to  claim 1 , wherein the surface of the first nonwoven fabric layer containing a silicon-releasable calcium carbonate and a biodegradable resin as principal components is coated with an apatite, the apatite having been deposited through soaking in a simulated body fluid. 
     
     
         3 . The guided bone regeneration membrane according to  claim 2 , wherein the biodegradable resin is a poly(lactic acid). 
     
     
         4 . The guided bone regeneration membrane according to  claim 2 , wherein the biodegradable resin is a poly(lactic acid). 
     
     
         5 . The guided bone regeneration membrane according to  claim 1 , wherein the silicon-releasable calcium carbonate is of vaterite phase. 
     
     
         6 . The guided bone regeneration membrane according to  claim 2 , wherein the silicon-releasable calcium carbonate is of vaterite phase. 
     
     
         7 . The guided bone regeneration membrane according to  claim 3 , wherein the silicon-releasable calcium carbonate is of vaterite phase. 
     
     
         8 . The guided bone regeneration membrane according to  claim 4 , wherein the silicon-releasable calcium carbonate is of vaterite phase. 
     
     
         9 . A method for manufacturing a guided bone regeneration membrane, the method comprising the steps of:
 forming a first nonwoven fabric through electrospinning, the first nonwoven fabric containing a silicon-releasable calcium carbonate and a biodegradable resin as principal components; and   forming a second nonwoven fabric through electrospinning, the second nonwoven fabric containing a biodegradable resin as a principal component.   
     
     
         10 . The method for manufacturing a guided bone regeneration membrane, according to  claim 9 , wherein the biodegradable resin is a polylactic acid). 
     
     
         11 . The method for manufacturing a guided bone regeneration membrane, according to  claim 9 , wherein the silicon-releasable calcium carbonate is of a vaterite phase. 
     
     
         12 . The method for manufacturing a guided bone regeneration membrane, according to  claim 10 , wherein the silicon-releasable calcium carbonate is of a vaterite phase.