Treatment of Conditions Through Modulation of the Autonomic Nervous System During at Least One Predetermined Menstrual Cycle Phase

Abstract

Methods are provided for treating a subject for a condition. In accordance with the subject methods, at least a portion of a subject's autonomic nervous system is modulated during at least one predetermined phase of the subject's menstrual cycle to alter the parasympathetic activity/sympathetic activity ratio in a manner that is effective to treat the subject for the condition. The subject methods find use in the treatment of a variety of different conditions, including various disease conditions, that increase in severity and/or occurrence during one or more phases of the menstrual cycle. Also provided are systems and kits for use in practicing the subject methods.

1 .- 68 . (canceled) 
   
   
       69 . A multi-dose pharmacological agent package comprising:
 a plurality of unit dosage forms of a pharmacological agent in a single pack, wherein the plurality of unit dosage forms is selected to modulate at least a portion of the autonomic nervous system to increase the parasympathetic activity/sympathetic activity ratio in a manner effective to treat a female subject for a condition which is increased in severity or occurrence during a phase of the subject's menstrual cycle.   
   
   
       70 . The multi-dose package according to  claim 69 , wherein the plurality of unit dosage forms comprises unit dosage forms for daily administration. 
   
   
       71 . The multi-dose package according to  claim 69 , wherein the plurality of unit dosage forms is in the form of a monthly pack. 
   
   
       72 . The multi-dose package according to  claim 69 , wherein the plurality of unit dosage forms is sufficient to treat the subject for 30 to 90 days. 
   
   
       73 . The multi-dose package according to  claim 69 , wherein the plurality of unit dosage forms comprises two different dosages of the pharmacological agent. 
   
   
       74 . The multi-dose package according to  claim 73 , wherein the number of unit dosage forms of a first dosage in the pack is equal to the number of days of a particular phase of the subject's menstrual cycle over the treatment period. 
   
   
       75 . The multi-dose package according to  claim 69 , wherein the pack further comprises a second pharmacological agent. 
   
   
       76 . The multi-dose package according to  claim 75 , wherein the second pharmacological agent is effective for treating the subject for a second condition which is increased in severity or occurrence during a phase of the subject's menstrual cycle. 
   
   
       77 . The multi-dose package according to  claim 69 , wherein each of the unit dosage forms is individually packaged. 
   
   
       78 . A method of treating a female subject for a condition which is increased in severity or occurrence during a phase of the subject's menstrual cycle, the method comprising:
 administering to the subject one of a plurality of unit dosage forms of a pharmacological agent contained in a single pack, wherein the plurality of unit dosage forms is selected to modulate at least a portion of the autonomic nervous system to increase the parasympathetic activity/sympathetic activity ratio in a manner effective to treat the subject for a condition which is increased in severity or occurrence during a phase of the subject's menstrual cycle.   
   
   
       79 . The method according to  claim 78 , wherein the plurality of unit dosage forms comprises unit dosage forms for daily administration. 
   
   
       80 . The method according to  claim 78 , wherein the plurality of unit dosage forms is in the form of a monthly pack. 
   
   
       81 . The method according to  claim 78 , wherein the plurality of unit dosage forms is sufficient to treat the subject for 30 to 90 days. 
   
   
       82 . The method according to  claim 78 , wherein the plurality of daily unit dosage forms comprises two different dosages of the pharmacological agent. 
   
   
       83 . The method according to  claim 82 , wherein the number of daily unit dosage forms of a first dosage in the pack is equal to the number of days of a particular phase of the subject's menstrual cycle. 
   
   
       84 . The method according to  claim 78 , wherein the pack further comprises a second pharmacological agent. 
   
   
       85 . The method according to  claim 84 , wherein the second pharmacological agent is effective for treating the subject for a second condition which is increased in severity or occurrence during a phase of the subject's menstrual cycle. 
   
   
       86 . The multi-dose package according to  claim 78 , wherein each of the unit dosage forms is individually packaged.