Composition, method and use of bi-functional biomaterials

Abstract

The present invention includes a bifunctional specificity structure that includes a peptide linker having a first and a second binding domain, wherein the first binding domain is selective for a first biomaterial and the second binding domain is selective for a second biomaterial. The present invention also includes a method of making and identifying the bifunctional structure of the present invention and methods of using the same.

1 - 38 . (canceled) 
     
     
         39 . A method of making a bifunctional linker comprising the steps of:
 selecting a peptide comprising a first binding domain peptide from a library of peptides that binds selectively to a biomaterial; and   including a second binding domain with the peptide that binds selectively to a target material.   
     
     
         40 . The method of  claim 39 , wherein the library comprises peptides having an amino acid length of about 7 to about 30 amino acids. 
     
     
         41 . The method of  claim 39 , wherein the library is a peptide phage display library. 
     
     
         42 . The method of  claim 39 , wherein the first binding domain is defined further as selected from the group consisting of SEQ. ID NOS: 1-22. 
     
     
         43 . The method of  claim 39 , wherein the second binding domain is defined further as a peptide that binds selectively to a protein. 
     
     
         44 . The method of  claim 39 , wherein the second binding domain is defined further as a peptide and wherein the peptide selectively binds to a plastic, ceramic, metal, composite, polymer, and modifications and/or combinations thereof. 
     
     
         45 . The method of  claim 39 , wherein the first binding domain binds non-covalently to a biomaterial. 
     
     
         46 . The method of  claim 39 , wherein the biomaterial is further defined as comprising one or more chloride doped polypyrrole subunits. 
     
     
         47 . The method of  claim 39 , wherein the biomaterial is defined further as comprising magnetic properties. 
     
     
         48 . The method of  claim 39 , wherein the target material further comprises one or more growth factors. 
     
     
         49 . The method of  claim 39 , wherein the target material is further defined as a matrix that is biocompatible with nerve tissue. 
     
     
         50 . The method of  claim 39 , wherein the first binding domain is selective for a poly-lactic acid based polymer. 
     
     
         51 . The method of  claim 39 , wherein the first binding domain is a peptide that binds specifically to poly (lactic acid-co-glycolic acid). 
     
     
         52 . The method of  claim 39 , wherein the biomaterial is further defined as being biocompatible. 
     
     
         53 . The method of  claim 39 , wherein the biomaterial is further defined as being biodegradable. 
     
     
         54 - 69 . (canceled)