Complex combining an organic silicon derivative with hyaluronic acid calibrated fragments, for preventive and repairing action of cutaneous damages

Abstract

The invention concerns a complex based on an organic silicon derivative. The invention is characterized in that said derivative is combined, by weak bonds, with one or several hyaluronic acid calibrated fragments of molecular weight comprised between 150 and 750 kDa, said derivative being of general formula (I): R X Si(OH) 4-x   (I) wherein: R is a (C 1 -C 4 )alkyl, x=1 and 2. The invention also concerns the use of such a complex in the prevention or the repair of cutaneous damages.

1 . A complex based on an organic silicon derivative wherein said derivative is combined, by weak bonds, with one or several hyaluronic acid calibrated fragments of molecular weight between 150 and 750 kDa, said derivative being of general formula (I):
   R X Si(OH) 4-x   (I)   wherein:
 R is a (C 1 -C 4 )alkyl, 
 x=1 and 2. 
   
   
   
       2 . The complex according to  claim 1 , wherein the molecular weight of said fragments are between 150 and 600 kDa. 
   
   
       3 . The complex according to  claim 1 , wherein the molecular weight of said fragments are between 250 and 600 kDa. 
   
   
       4 . The complex according to  claim 1 , wherein said organic silicon derivative of formula (I) is chosen among the monomethylsilanetriol or the dimethylsilanediol. 
   
   
       5 . The complex according to  claim 4 , wherein the organic silicon derivative is the monomethylsilanetriol. 
   
   
       6 . The complex according to  claim 1 , wherein the monomethylsilanetriol is combined with one or several hyaluronic acid fragments of molecular weight between 150 and 600 kDa or between 250 and 600 kDa. 
   
   
       7 . A cosmetic composition for topical application intended for preventing or repairing cutaneous damages related to aging wherein it includes, in association with any physiologically compatible excipient with skin, as main active ingredient, a complex according to  claim 1 . 
   
   
       8 . The cosmetic composition according to  claim 7 , wherein the quantity of complex of formula (I) is between 1 and 10% in weight in relation to the total weight of the composition, preferably between 2 and 5% in weight. 
   
   
       9 . The cosmetic composition according to  claim 7 , wherein it is formulated under the form of cream, milk, gel, lotion, emulsion. 
   
   
       10 . A cosmetic care process intended for preventing or repairing cutaneous damages related to aging, the process achieved by applying on skin a composition such as defined in  claim 7 . 
   
   
       11 . A process intended for boosting the epidermal cell activity and limiting the catabolic action of the cutaneous tissue comprising administering a complex such as defined to  claim 1  as a cytostimulating agent.