Retinol formulations and methods for their use

Abstract

A composition for the treatment of skin comprises a non-emulsified, aqueous suspension of retinol. The composition may further include at least one protein species, and some proteins used in the composition include collagen and elastin. The composition may also include hyaluronic acid. The composition may also include one or more of tocopheryl acetate, propylene glycol, and linseed extract. Also disclosed are methods for making the composition and use of the composition for the treatment of skin.

1 . A composition for the treatment of skin, said composition comprising:
 a non-emulsified, aqueous suspension of retinol.   
     
     
         2 . The composition of  claim 1 , further including at least one protein species. 
     
     
         3 . The composition of  claim 2 , wherein said at least one protein species is selected from the group consisting of: collagen, elastin, and combinations thereof. 
     
     
         4 . The composition of  claim 1 , further including hyaluronic acid. 
     
     
         5 . The composition of  claim 1 , further including an ancillary ingredient selected from the group consisting of: thickeners, fragrances, coloring agents, preservatives, buffers, and combinations thereof. 
     
     
         6 . A composition for the treatment of skin, said composition comprising, on a weight basis:
 0.1-5.0% retinol;   1-20% of at least one protein species; and   water, said composition characterized in that it is not an emulsion, and said retinol is suspended in said water.   
     
     
         7 . The composition of  claim 6 , wherein said retinol is in the form of droplets having a size in the range of 5-500 microns. 
     
     
         8 . The composition of  claim 6 , further including 0.1-5% by weight of hyaluronic acid. 
     
     
         9 . A composition for the treatment of skin, said composition comprising, on a weight basis:
 0.1-5% retinol;   1-15% soluble collagen;   0.5-5% hydrolyzed elastin;   0.2-2% hyaluronic acid;   0.5-10% glycerin; and   the remainder water.   
     
     
         10 . The composition of  claim 9 , further including, on a weight basis, at least one of
 0.5-5% propylene glycol;   0.1-2% tocopheryl acetate;   0.5-5% Linum usitatissimum (linseed) seed extract;   0.5-5% magnesium aluminum silicate;   0.1-3% octoxynol-9;   0.1-2% quaternium-15;   0.1-5% polysorbate 20; and   0.1-2% xanthan gum.   
     
     
         11 . The composition of  claim 9 , further characterized in that said composition is not an emulsion. 
     
     
         12 . A composition for the treatment of skin, said composition comprising, on a weight basis:
 0.99% magnesium aluminum silicate;   8.00% soluble collagen;   2.00% hydrolyzed elastin;   1.00% sodium hyaluronate;   0.98% Linum usitatissimum (linseed) seed extract;   1.00% retinol/polysorbate 20 (50/50 mixture);   0.50% tocopheryl acetate;   0.80% octoxynol-9;   0.30% quaternium-15;   0.90% propylene glycol;   3.00% glycerin;   0.50% xanthan gum; and   the balance water.   
     
     
         13 . The composition of  claim 12 , further including one or more ancillary agent selected from the group consisting of: coloring agents, fragrances, thickening agents, buffers, and preservatives. 
     
     
         14 . A composition for the treatment of skin, said composition comprising, on a weight basis:
 0.99% magnesium aluminum silicate;   8.00% soluble collagen;   2.00% hydrolyzed elastin;   1.00% sodium hyaluronate;   0.98% Linum usitatissimum (linseed) seed extract;   2.00% retinol/polysorbate 20 (50/50 mixture);   0.50% tocopheryl acetate;   0.80% octoxynol-9;   2.50% polysorbate 20;   0.30% quaternium-15;   0.90% propylene glycol;   3.00% glycerin;   0.50% xanthan gum; and   the balance water.   
     
     
         15 . The composition of  claim 14 , further including one or more ancillary agent selected from the group consisting of: coloring agents, fragrances, thickening agents, buffers, and preservatives. 
     
     
         16 . A method for the treatment of skin, said method comprising applying to the skin a composition comprising, on a weight basis:
 0.1-5.0% retinol;   1-20% of at least one protein species; and   the remainder water;   wherein said composition is characterized in that it is not an emulsion, and said retinol is suspended in water.