Tobacco and tobacco packaging material for preventing or reducing tobacco-associated injury in the aerodigestive tract of a subject

Abstract

Articles of manufacturing for preventing or reducing tobacco smoke- and smokeless-tobacco associated injury in the aerodigestive tract of a subject are disclosed, which comprise at least one agent capable of reducing or preventing tobacco associated loss of peroxidase activity in said aerodigestive tract, said at least one agent being selected from the group consisting of a cyanide chelator and an iron chelator.

1 . A article of manufacturing comprising tobacco and a tobacco packaging material, at least a portion of said tobacco and/or tobacco packaging material being in contact with an aerodigestive tract of a subject in use thereof, and whereas said at least a portion of said tobacco and/or tobacco packaging material comprises at least one agent capable of reducing or preventing tobacco associated loss of peroxidase activity in said aerodigestive tract, said at least one agent being selected from the group consisting of a cyanide chelator and an iron chelator. 
   
   
       2 . An article of manufacturing comprising a tobacco packaging material at least a portion of which being in contact with an aerodigestive tract of a subject in use thereof, wherein said at least a portion comprises an agent capable of reducing or preventing tobacco associated loss of peroxidase activity in said aerodigestive tract. 
   
   
       3 . The article of manufacturing of  claim 1 , wherein said tobacco packaging material comprises a filter and said at least one agent is impregnated in a paper of said filter being in contact with said aerodigestive tract of said subject in use thereof. 
   
   
       4 . The article of manufacturing of  claim 1 , wherein said tobacco is smokeless tobacco. 
   
   
       5 . The article of manufacturing of  claim 1 , wherein said tobacco is smoked tobacco. 
   
   
       6 . The article of manufacturing of  claim 1 , wherein said tobacco packaging material is selected from the group consisting of a rolling paper, a filter paper, a suns bag packaging, a cigarette, a pipe and a tin sheet packaging. 
   
   
       7 . The article of manufacturing of  claim 1 , selected from the group consisting of a snuff, a cigarette, a snus, a Gutka, a plug, a twist, a scrap and tobacco water. 
   
   
       8 . The article of manufacturing of  claim 1 , wherein said cyanide chelator is hydroxocobalamin. 
   
   
       9 . The article of manufacturing of  claim 1 , wherein said agent is capable of reducing or preventing tobacco smoke-associated death of cells in the digestive tract of a subject. 
   
   
       10 . The article of manufacturing of  claim 9 , wherein said cells are lymphocytes and/or epithelial cells. 
   
   
       11 . The article of manufacturing of  claim 1 , wherein said iron chelator is deferoxamine. 
   
   
       12 . The article of manufacturing of  claim 1 , wherein said at least one agent further comprises an antioxidant. 
   
   
       13 . The article of manufacturing of  claim 12 , wherein said antioxidant is glutathione. 
   
   
       14 . The article of manufacturing of  claim 1 , wherein said tobacco packaging material comprises a filter and said at least one agent is impregnated in a paper of said filter being in contact with said aerodigestive tract of said subject in use thereof. 
   
   
       15 . The article of manufacturing of  claim 2 , wherein said tobacco is smokeless tobacco. 
   
   
       16 . The article of manufacturing of  claim 2 , wherein said tobacco is smoked tobacco. 
   
   
       17 . The article of manufacturing of  claim 2  wherein said tobacco packaging material is selected from the group consisting of a rolling paper, a filter paper, a suns bag packaging, a cigarette, a pipe and a tin sheet packaging. 
   
   
       18 . The article of manufacturing of  claim 2 , wherein said ron chelator is deferoxamine. 
   
   
       19 . The article of manufacturing of  claim 2 , wherein said at least one agent further comprises an antioxidant. 
   
   
       20 . The article of manufacturing of  claim 19 , wherein said antioxidant is glutathione.