Administration of pyridinedicarboxylic acid compounds for stimulating or inducing the growth of human keratinous fibers and/or arresting their loss

Abstract

The invention relates to the use in a composition for caring for human hair or eyelashes of an effective amount of a pyridinedicarboxylic acid derivative of general formula (I) or of one of its salts, in which R 1 and R 2 represent, independently of one another, OH, OR′, —NH 2 , —NHR′ or —NR′R″, and R′ and R″ represent, independently of one another, a saturated or unsaturated and linear or branched C 1 -C 18 alkyl radical or an aryl radical, this alkyl or aryl radical optionally being substituted by at least one OH, alkoxy, acyloxy, amino or alkylamino group, or R′ and R″ together represent a heterocycle, the composition being intended to induce and/or stimulate the growth of human keratinous fibers, such as the hair and eyelashes, and/or slow down their loss; the invention also relates to a cosmetic treatment intended to stimulate the growth of human keratinous fibers, such as the hair and eyelashes, and/or slow down their loss.

1 . A regime or regimen for inducing/stimulating the growth of human keratinous fibers and/or retarding the loss and/or increasing the density thereof, comprising administering to an individual subject in need of such treatment, a thus effective amount of at least one pyridinedicarboxylic acid compound having the following structural formula (I), or salt thereof: 
     
       
         
         
             
             
         
       
     
     in which R 1  and R 2 , which may be identical or different, are each —NH 2 , —NHR′ or —NR′R″, wherein R′ and R″, which also may be identical or different, are each a saturated or unsaturated linear or branched C 1 -C 18  alkyl radical or an aryl radical, or a substituted such alkyl or aryl radical substituted with at least one OH, alkoxy, acyloxy, amino or alkylamino substituent, or R′ and R″ may together form a heterocyclic ring member. 
   
   
       2 . The regime or regimen as defined by  claim 1 , for inducing/stimulating the growth of human head hair, eyebrows, eyelashes, beard hairs, moustache hairs or pubic hairs and/or retarding the loss and/or increasing the density thereof. 
   
   
       3 . A regime or regimen for inducing/stimulating the growth of human head hair and/or retarding the loss and/or increasing the density thereof, comprising topically applying onto the hair and/or scalp of an individual in need of such treatment, a thus effective amount of at least one pyridinedicarboxylic acid compound having the following structural formula (I), or salt thereof: 
     
       
         
         
             
             
         
       
     
     in which R 1  and R 2 , which may be identical or different, are each —NH 2 , —NHR′ or —NR′R″, wherein R′ and R″, which also may be identical or different, are each a saturated or unsaturated linear or branched C 1 -C 18  alkyl radical or an aryl radical, or a substituted such alkyl or aryl radical substituted with at least one OH, alkoxy, acyloxy, amino or alkylamino substituent, or R′ and R″ may together form a heterocyclic ring member. 
   
   
       4 . A regime or regimen for treating androgenic alopecia, comprising administering to an individual in need of such treatment, a thus effective amount of at least one pyridinedicarboxylic acid compound having the following structural formula (I), or salt thereof: 
     
       
         
         
             
             
         
       
     
     in which R 1  and R 2 , which may be identical or different, are each —NH 2 , —NHR′ or —NR′R″, wherein R′ and R″, which also may be identical or different, are each a saturated or unsaturated linear or branched C 1 -C 18  alkyl radical or an aryl radical, or a substituted such alkyl or aryl radical substituted with at least one OH, alkoxy, acyloxy, amino or alkylamino substituent, or R′ and R″ may together form a heterocyclic ring member. 
   
   
       5 . A regime or regimen for caring for and/or making up human eyelashes, comprising topically applying thereon a thus effective amount of at least one pyridinedicarboxylic acid compound having the following structural formula (I), or salt thereof: 
     
       
         
         
             
             
         
       
     
     in which R 1  and R 2 , which may be identical or different, are each —NH 2 , —NHR′ or —NR′R″, wherein R′ and R″, which also may be identical or different, are each a saturated or unsaturated linear or branched C 1 -C 18  alkyl radical or an aryl radical, or a substituted such alkyl or aryl radical substituted with at least one OH, alkoxy, acyloxy, amino or alkylamino substituent or, R′ and R″ may together form a heterocyclic ring member. 
   
   
       6 . The regime or regimen as defined by  claim 1 , wherein formula (I), R 1  and R 2 , which may be identical or different, are each:
   NHCH 2 —CH 2 —CH 3 , NH—CH 2 —CH 2 OH, NH—CH 2 —CH 2 —CH 2 OH or NH—CH 2 —CH 2 OCH 3 .   
   
   
       7 . The regime or regimen as defined by  claim 1 , wherein formula (I), R 1  and R 2 , are respectively in the 2 and 3 or 2 and 4 positions of the pyridine ring. 
   
   
       8 . The regime or regimen as defined by  claim 1 , comprising administering a salt of said at least one pyridinedicarboxylic acid compound of formula (I), selected from the group consisting of the double salt of sodium or of potassium, zinc (Zn 2+ ), calcium (Ca 2+ ), copper (Cu 2+ ), iron (Fe 2+ ), strontium (Sr 2+ ), magnesium (Mg 2+ ) and manganese (Mn 2+ ) salts, triethanolamine, monoethanolamine, diethanolamine, hexadecylamine, N,N,N′,N′-tetrakis(2-hydroxypropyl)-ethylenediamine or tris(hydroxymethyl)aminomethane salts, hydroxides, carbonates and chlorides. 
   
   
       9 . The regime or regimen as defined by  claim 1 , comprising administering a thus effective amount of:
 2,4-di(n-propylamido) pyridine,   2,4-di(2-hydroxyethylamido)pyridine,   2,4-di(3-hydroxypropylamido)pyridine, or mixture thereof.   
   
   
       10 . A cosmetic/pharmaceutical composition of matter suited for inducing/stimulating the growth of human keratinous fibers and/or retarding the loss and/or increasing the density thereof, comprising a thus effective amount of at least one pyridinedicarboxylic acid compound having the 
     
       
         
         
             
             
         
       
     
     following structural formula (I), or salt thereof:
 in which R 1  and R 2 , which may be identical or different, are each —NH 2 , —NHR′ or —NR′R″, wherein R′ and R″, which also may be identical or different, are each a saturated or unsaturated linear or branched C 1 -C 18  alkyl radical or an aryl radical, or a substituted such alkyl or aryl radical substituted with at least one OH, alkoxy, acyloxy, amino or alkylamino substituent, or R′ and R″ may together form a heterocyclic ring member, formulated into a nontoxic physiologically acceptable medium therefor. 
 
   
   
       11 . A topically applicable cosmetic/pharmaceutical composition of matter suited for inducing/stimulating the growth of human keratinous fibers and/or retarding the loss and/or increasing the density thereof, comprising a thus effective amount of at least one pyridinedicarboxylic acid compound having the following structural formula (I), or salt thereof: 
     
       
         
         
             
             
         
       
     
     in which R 1  and R 2 , which may be identical or different, are each —NH 2 , —NHR′ or —NR′R″, wherein R′ and R″, which also may be identical or different, are each a saturated or unsaturated linear or branched C 1 -C 18  alkyl radical or an aryl radical, or a substituted such alkyl or aryl radical substituted with at least one OH, alkoxy, acyloxy, amino or alkylamino substituent, or R′ and R″ may together form a heterocyclic ring member formulated into a topically applicable, nontoxic physiologically acceptable medium therefor. 
   
   
       12 . The topically applicable cosmetic/pharmaceutical composition as defined by  claim 11 , formulated as a hair cream or lotion, shampoo, hair conditioner, or mascara. 
   
   
       13 . The cosmetic/pharmaceutical composition as defined by  claim 10 , formulated as an aqueous, alcoholic or aqueous/alcoholic solution or suspension. 
   
   
       14 . The cosmetic/pharmaceutical composition as defined by  claim 10 , further comprising at least one hydrophilic or lipophilic gelling agent or thickener, hydrophilic or lipophilic additive, preservative, antioxidant, solvent, fragrance, filler, odor absorber, electrolyte, neutralizing agent, UV blocking agent, film-forming polymer, cosmetic and pharmaceutical active principle eliciting a therapeutic effect on the skin or keratinous fibers, colorant, substance P, CGRP or bradykinin antagonist, NO-synthase inhibitor, or mixture thereof. 
   
   
       15 . The cosmetic/pharmaceutical composition as defined by  claim 10 , further comprising at least one other active agent which promotes the regrowth of human keratinous fibers and/or limits the loss thereof. 
   
   
       16 . The cosmetic/pharmaceutical composition as defined by  claim 10 , further comprising at least one:
 hormone;   antibacterial agent;   calcium antagonist agent;   microorganism extract;   agent which modulates cutaneous differentiation and/or proliferation;   agent which modulates bacterial adhesion to the skin and/or mucous membranes;   agent for combating parasites;   antifungal;   antiviral agent;   steroidal or nonsteroidal anti-inflammatory agent;   anaesthetic agent;   antipruriginous agent;   keratolytic agent;   agent for combating free radicals;   antiseborrheic;   antidandruff agent;   anti-acne agent;   vasodilator;   agent which reduces hair loss;   anti-androgen agent;   steroidal or nonsteroidal inhibitor of reductases;   potassium channel agonist;   FP receptor agonist; or mixture thereof.   
   
   
       17 . The topically applicable cosmetic/pharmaceutical composition as defined by  claim 11 , further comprising at least one other active agent which promotes the regrowth of human keratinous fibers and/or which limits the loss thereof, selected from the group consisting of aminexil, minoxidil, latanoprost, travoprost, and mixtures thereof. 
   
   
       18 . The cosmetic/pharmaceutical composition as defined by  claim 10 , further comprising at least one other active agent which promotes the regrowth of human keratinous fibers and/or which limits the loss thereof, selected from the group consisting of aminexil, an FP receptor, a vasodilator, and mixtures thereof. 
   
   
       19 . The cosmetic/pharmaceutical composition as defined by  claim 10 , comprising from 10 −3 % to 10% by weight of said at least one pyridinedicarboxylic acid compound of formula (I), or salt thereof. 
   
   
       20 . The cosmetic/pharmaceutical composition as defined by  claim 10 , comprising from 10 −2 % to 5% by weight of said at least one pyridinedicarboxylic acid compound of formula (I), or salt thereof. 
   
   
       21 . The cosmetic/pharmaceutical composition as defined by  claim 10 , formulated for administration by injection. 
   
   
       22 . The cosmetic/pharmaceutical composition as defined by  claim 10 , formulated for administration by ingestion.