Dipterinyl Calcium Pentahydrate (DCP) and Therapeutic Methods Based Thereon

Abstract

Provided herein is dipterinyl calcium pentahydrate (DCP) and therapeutic methods based thereon. Also provided herein is the compound dipterinyl calcium pentahydrate (DCP) or an analog or polymorph thereof.

1 .- 3 . (canceled) 
   
   
       4 . A method of treating disease in a subject comprising the administration of a therapeutically effective amount of a compound of formula (I):
   M(pterin) x (H2O) y      wherein:   M is a bivalent metal ion selected from the group consisting of Ca 2+ , Cu 2+ , Mg 2+ , V 2+ , Cr 2+ , Mn 2+ , Fe 2+ , Mo 2+ , Zn 2+ , Sr 2+ , Ba 2+ , Ra 2+ , Ru 2+ , Rh 2+ , Pd 2+ , Cd 2+ , Sn 2+ , W 2+ , Re 2+ , Os 2+ , Ir 2+ , Pt 2+ , Si 2+ , and Sm 2+ ;   X is an integer from 1 to 8; and   y is an integer of from 1 to 8.   
   
   
       5 . The method of  claim 4  wherein the compound of formula (I) is dipterinyl calcium pentahydrate (DCP). 
   
   
       6 . The method of  claim 5  wherein the disease is a neoplastic disease. 
   
   
       7 . The method of  claim 5  wherein the disease is an infectious disease. 
   
   
       8 . The method of  claim 6  comprising modulating tryptophan degradation. 
   
   
       9 . The method of  claim 6  comprising modulating neopterin production. 
   
   
       10 . The method of  claim 6  comprising modulating IFN-γ production. 
   
   
       11 . The method of  claim 6  comprising modulating the activity of the enzyme IDO. 
   
   
       12 . The method of  claim 6  comprising modulating immune resistance in human solid tumors. 
   
   
       13 .- 21 . (canceled)