US2010099879A1PendingUtilityA1

Process for making montelukast and intermediates therefor

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Assignee: BENOVSKY PETRPriority: Nov 18, 2005Filed: Oct 9, 2009Published: Apr 22, 2010
Est. expiryNov 18, 2025(expired)· nominal 20-yr term from priority
Inventors:Petr BenovskyLambertus ThijsArjanne OvereemJakub CastulikJie ZhuPetr BartosRadomir Skoumal
A61P 37/08C07C 2601/02C07D 409/10C07D 215/18C07C 309/75A61P 11/06
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Claims

Abstract

The reaction of methylmagnesium halide is improved by the presence of a cerium (III) salt such as cerium trichloride. The reactions are typically associated with the production of montelukast, a pharmaceutically useful compound of the following formula and salts thereof. Further enhancements can be derived from certain intermediates, salts thereof and/or purification thereof before and/or after the reaction involving methylmagnesium halide.

Claims

exact text as granted — not AI-modified
1 . An acid addition salt selected from the group consisting of the compounds of formulas (4a), (4b), and (4c): 
     
       
         
         
             
             
         
       
     
   
   
       2 . The salt according to  claim 1 , wherein said salt is in crystalline form. 
   
   
       3 . The salt according to  claim 1 , wherein said salt is a compound of formula (4b) or (4c). 
   
   
       4 . The salt according to  claim 3 , wherein said salt is in crystalline form. 
   
   
       5 . An acid addition salt selected from the compounds of formulas (20a) and (20b):

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