Carbohydrate-based peritoneal dialysis fluid comprising glutamine residue

Abstract

The present invention relates to a carbohydrate-based peritoneal dialysis fluid, containing a compound selected from the group consisting of glutamine, preferably L-glutamine, a dipeptide capable of releasing glutamine, L-glutamine in free form, preferably selected from the group consisting of glutaminyl-glycine, glycinyl-glutamine, glutaminyl-alanine, alanyl-glutamine an oligopeptide consisting of two to seven glutamine, preferably L-glutamine residues, and mixtures thereof. The peritoneal dialysis fluids of the present invention are useful for inhibition of technical failure in a person undergoing peritoneal dialysis treatment.

1 . A glucose-based peritoneal dialysis fluid, containing a compound selected from the group consisting of
 L-glutamine,   a dipeptide capable of releasing L-glutamine, in free form, preferably selected from the group consisting of glutaminyl-glycine, glycinyl-glutamine, glutaminyl-alanine and alanyl-glutamine   an oligopeptide consisting of two to seven L-glutamine residues, and   mixtures thereof,   
     wherein the concentration of said compound in the fluid is 2 mM to 25 mM. 
   
   
       2 . A compound selected from the group consisting of
 L-glutamine,   a dipeptide capable of releasing L-glutamine, in free form, preferably selected from the group consisting of glutaminyl-glycine, glycinyl-glutamine, glutaminyl-alanine and alanyl-glutamine   an oligopeptide consisting of two to seven L-glutamine residues and   mixtures thereof,   
     wherein the concentration of said compound in the fluid is 2 mM to 25 mM, 
     for the specific use of inhibiting technical failure in a peritoneal dialysis treatment with a glucose-based peritoneal dialysis fluid. 
   
   
       3 . A glucose-based peritoneal dialysis fluid comprising a compound selected from the group consisting of
 L-glutamine,   a dipeptide capable of releasing L-glutamine, in free form, preferably selected from the group consisting of glutaminyl-glycine, glycinyl-glutamine, glutaminyl-alanine and alanyl-glutamine   an oligopeptide consisting of two to seven L-glutamine residues, and   mixtures thereof,   
     wherein the concentration of said compound in the fluid is 2 mM to 25 mM, 
     for the specific use of inhibiting technical failure. 
   
   
       4 . The peritoneal dialysis fluid and/or compound according to any of  claims 1  to  3 , characterized in that said oligopeptide is selected from the group consisting of alanyl-glutamine and glutaminyl-alanine. 
   
   
       5 . The peritoneal dialysis fluid and/or compound according to  claim 4  for the specific use of prevention of peritoneal membrane failure, attenuation of barrier dysfunction and prevention of mesothelial cell detachment. 
   
   
       6 . Use of a compound selected from the group consisting of
 L-glutamine,   a dipeptide capable of releasing L-glutamine, in free form, preferably selected from the group consisting of glutaminyl-glycine, glycinyl-glutamine, glutaminyl-alanine, alanyl-glutamine   an oligopeptide consisting of two to seven L-glutamine residues, and   mixtures thereof,   
     wherein the concentration of said compound in the fluid is 2 mM to 25 mM, 
     for the preparation of a glucose-based peritoneal dialysis fluid for inhibiting technical failure. 
   
   
       7 . Use according to  claim 6  for the prevention of peritoneal membrane failure, attenuation of barrier dysfunction and prevention of mesothelial cell detachment.