Nucleic acid and corresponding protein entitled 205p1b5 useful in treatment and detection of cancer

Abstract

A novel gene (designated 205P1B5) and its encoded protein are described. While 205P1B5 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in prostate cancer. Consequently, 205P1B5 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 205P1B5 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.

1 . A recombinant or isolated polypeptide encoded by a polynucleotide selected from the group consisting of
 (a) a polynucleotide having the sequence of SEQ ID NO: 701;   (b) a polynucleotide having the sequence of SEQ ID NO: 701, from nucleotide residue number 555 through nucleotide residue number 2144; and   (c) a polynucleotide encoding a 205P1B5 protein having the amino acid sequence SEQ ID NO: 702.   
     
     
         2 . An isolated polypeptide of  claim 1  which is encoded by a polynucleotide having the sequence of SEQ ID NO: 701. 
     
     
         3 . An isolated polypeptide of  claim 1  which is encoded by a polynucleotide having the sequence of SEQ ID NO: 1, from nucleotide residue number 555 through nucleotide residue number 2144. 
     
     
         4 . An isolated polypeptide of  claim 1  which is encoded by a polynucleotide encoding a 205P1B5 protein having the amino acid sequence SEQ ID NO: 702. 
     
     
         5 . The polypeptide of  claim 1  which is further extended by an additional amino acid sequence as a fusion protein. 
     
     
         6 . A polypeptide according to  claim 1  which is labeled with a detectable marker. 
     
     
         7 . The polypeptide of  claim 6  wherein the detectable marker is selected from the group consisting of a radioisotope, a fluorescent compound, a bioluminescent compound, a chemiluminescent compound, a metal chelator and an enzyme. 
     
     
         8 . A recombinant or isolated polypeptide having the amino acid sequence SEQ ID NO: 702. 
     
     
         9 . An isolated polypeptide of  claim 7  which is encoded by a polynucleotide having the sequence of SEQ ID NO: 701. 
     
     
         10 . An isolated polypeptide of  claim 7  which is encoded by a polynucleotide having the sequence of SEQ ID NO: 1, from nucleotide residue number 555 through nucleotide residue number 2144. 
     
     
         11 . A polypeptide according to  claim 7  which is labeled with a detectable marker. 
     
     
         12 . The polypeptide of  claim 7  wherein the detectable marker is selected from the group consisting of a radioisotope, a fluorescent compound, a bioluminescent compound, a chemiluminescent compound, a metal chelator and an enzyme.