Retrovirus-infection inhibitor

Abstract

An infection inhibitor of retrovirus, particularly human immunodeficiency virus, comprising, as an active ingredient, at least one compound selected from the group consisting of a compound represented by the formula (I) (GGA) or a salt thereof, a compound represented by the formula (II) (NIK-333) or a salt thereof, and derivatives thereof.

1 . A retrovirus-infection inhibitor comprising, as an active ingredient, at least one compound selected from the group consisting of a compound represented by the formula (I) or a salt thereof, a compound represented by the formula (II) or a salt thereof, and derivatives thereof: 
     
       
         
         
             
             
         
       
     
   
   
       2 . The inhibitor of  claim 1 , wherein the active ingredient is a compound represented by the formula (I) or a salt thereof, or a compound represented by the formula (II) or a salt thereof. 
   
   
       3 . The inhibitor of  claim 1 , wherein the retrovirus is a human immunodeficiency virus. 
   
   
       4 . The inhibitor  claim 1 , wherein the inhibition of retrovirus infection is based on a CXCR4 expression lowering action. 
   
   
       5 . A therapeutic agent for HIV infection, comprising, as an active ingredient, at least one compound selected from the group consisting of a compound represented by the formula (I) or a salt thereof, a compound represented by the formula (II) or a salt thereof, and derivatives thereof. 
   
   
       6 . A method of suppressing retrovirus infection, comprising administering an effective amount of at least one compound selected from the group consisting of a compound represented by the formula (I) or a salt thereof, a compound represented by the formula (II) or a salt thereof, and derivatives thereof to a subject in need of the administration. 
   
   
       7 . The method of  claim 6 , wherein a compound represented by the formula (I) or a salt thereof, or a compound represented by the formula (II) or a salt thereof is administered in an effective amount to the subject. 
   
   
       8 . The method of  claim 6 , wherein the retrovirus is a human immunodeficiency virus. 
   
   
       9 . The method of  claim 6 , wherein the suppression of retrovirus infection is based on a CXCR4 expression lowering action. 
   
   
       10 . A therapeutic method of HIV infection, comprising administering an effective amount of at least one compound selected from the group consisting of a compound represented by the formula (I) or a salt thereof, a compound represented by the formula (II) or a salt thereof, and derivatives thereof to a subject in need of the administration. 
   
   
       11 . The inhibitor of  claim 2 , wherein the inhibition of retrovirus infection is based on a CXCR4 expression lowering action. 
   
   
       12 . The inhibitor of  claim 3 , wherein the inhibition of retrovirus infection is based on a CXCR4 expression lowering action. 
   
   
       13 . The method of  claim 7 , wherein the suppression of retrovirus infection is based on a CXCR4 expression lowering action. 
   
   
       14 . The method of  claim 8 , wherein the suppression of retrovirus infection is based on a CXCR4 expression lowering action.