Method for treating kidney disorders

Abstract

The present invention relates to a method for treating, delaying and/or preventing renal dysfunction/failure in a mammal comprising administering a therapeutically effective amount of a substance capable of inducing and/or enhancing Pax 2 expression. Furthermore, the invention relates to the use of an effective dose of a substance capable of inducing and/or enhancing Pax 2 expression in a mammal for the preparation of a pharmaceutical composition for treating, preventing or delaying a renal dysfunction/failure in a mammal. Additionally, the present invention provides for a method for converting mesenchymal tissue into an epithelial tissue comprising the administration of an effective amount of a substance capable of inducing and/or enhancing Pax 2 expression in said mesenchym and for a method for the regeneration of renal stemcells comprising the administration of an effective amount of a substance capable of inducing and/or enhancing Pax 2 expression.

1 .- 30 . (canceled) 
   
   
       31 . A method for regenerating renal stem cells in vitro comprising transforming dormant renal stem cells with a vector comprising a nucleic acid molecule encoding Pax2a or Pax2b protein, wherein said nucleic acid molecule is operatively linked to an expression control sequence. 
   
   
       32 . The method of  claim 31 , wherein said renal stem cells are isolated from a mammal. 
   
   
       33 . The method of  claim 31 , wherein said renal stem cells are isolated from a human.