Il-1 zeta, il-1 zeta splice variants and xrec2 dnas and polypeptides

Abstract

The invention is directed to novel, purified and isolated IL-1 zeta and Xrec2 polypeptides and fragments thereof, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and uses thereof.

1 . An isolated polynucleotide comprising a polynucleotide of SEQ ID NO:2. 
     
     
         2 . An isolated polynucleotide comprising a nucleic acid molecule that encodes a polypeptide comprising SEQ ID NO:4. 
     
     
         3 . A vector comprising the polynucleotide of  claim 1 . 
     
     
         4 . A vector comprising the polynucleotide of  claim 2 . 
     
     
         5 . A host cell transformed or transfected with the vector of  claim 3 . 
     
     
         6 . A host cell transformed or transfected with the vector of  claim 4 . 
     
     
         7 . A method for preparing a polypeptide, the method comprising culturing the host cell of  claim 5  under conditions promoting expression of the polypeptide. 
     
     
         8 . A method for preparing a polypeptide, the method comprising culturing the host cell of  claim 6  under conditions promoting expression of the polypeptide. 
     
     
         9 . An isolated polypeptide comprising SEQ ID NO:4. 
     
     
         10 . An oligomeric polypeptide comprising a polypeptide of  claim 9 . 
     
     
         11 . An isolated antibody that binds the polypeptide of  claim 9