Hydrobromide salt of an anti-hiv compound

Abstract

Solid dispersions and dosage forms comprising the hydrobromide salt of a diarylpyrimidine derivative, useful as an anti-HIV agent.

1 . A solid dispersion comprising a compound of formula (I): 
     
       
         
         
             
             
         
       
       in a water-soluble polymer. 
     
   
   
       2 . The solid dispersion of  claim 1 , wherein the water-soluble polymer is selected from hydroxypropylmethyl cellulose, polyvinyl pyrrolidone, copolyvidone, and vitamin E TGPS. 
   
   
       3 . The solid dispersion of  claim 4 , wherein the polymer is hydroxypropylmethyl cellulose 2910 5 cps 
   
   
       4 . The solid dispersion of  claim 3 , wherein the ratio of the polymer to pharmaceutical agent is in the range from 9:1 to 1:1. 
   
   
       5 . The solid dispersion of  claim 6 , wherein the ratio of polymer to pharmaceutical agent is in the range from 3:1 to 1:1. 
   
   
       6 . A dosage form comprising the compound of  claim 1  or  claim 2  or the solid dispersion of  claim 3 . 
   
   
       7 . The dosage form of  claim 9 , wherein the dosage form is selected from a tablet or a capsule. 
   
   
       8 . A compound of formula (I): 
     
       
         
         
             
             
         
       
     
   
   
       9 . The compound of  claim 1  having a degree of crystallinity of about 10% or less, or of about 5% or less, or of about 1% or less. 
   
   
       10 . A pharmaceutical composition comprising a compound of formula (I) as defined in  claim 8  and a carrier.