US2010041096A1PendingUtilityA1

Carcinostatic method using BRCA1-BARD1 pathway

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Assignee: OHTA TOMOHIKOPriority: Feb 2, 2004Filed: May 20, 2009Published: Feb 18, 2010
Est. expiryFeb 2, 2024(expired)· nominal 20-yr term from priority
Inventors:Tomohiko Ohta
C07K 14/47
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Claims

Abstract

The present invention provides a method of polyubiquitinating a nucleophosmin comprised of reacting the nucleophosmin in vitro or in vivo with BRCA1-BARD1. The present invention also provides a method of inhibiting polyubiquitination of nucleophosmin comprised of phosphorylating BARD1 using CDK2-cyclin E and/or CDK2-cyclin A.

Claims

exact text as granted — not AI-modified
1 . A method of polyubiquitinating a nucleophosmin comprising of reacting the nucleophosmin with BRCA1-BARD1. 
     
     
         2 . A method of stabilizing a nucleophosmin comprising of polyubiquitination of nucleophosmin. 
     
     
         3 . The method of  claim 1  or  2 , wherein polyubiquitination is carried out in vitro or in vivo. 
     
     
         4 .- 10 . (canceled)

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