US2010040618A1PendingUtilityA1

Prevention of tumors with monoclonal antibodies against neu

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Assignee: TRUSTEE OF THE UNIVERSITY OF PPriority: Mar 30, 1993Filed: Oct 15, 2009Published: Feb 18, 2010
Est. expiryMar 30, 2013(expired)· nominal 20-yr term from priority
Inventors:Mark I. GreeneMakoto KatsumataJeffrey Drebin
A61K 2039/505A61P 35/00C07K 16/32A61K 38/00
75
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Claims

Abstract

Methods of preventing the transformation of a normal cell into a tumor cell that has p185 on its surface are disclosed. The methods comprise administering an antibody which specifically binds to p185. Methods of preventing the transformation of a normal cell into a tumor cell that has p185 on its surface in an individual at high risk of developing tumors are disclosed.

Claims

exact text as granted — not AI-modified
1 . A method of preventing transformation of a normal cell into a tumor cell in an individual at risk of developing a tumor having tumor cells which have p185 on their surfaces, said method comprising the steps of:
 a) identifying said individual; and,   b) administering to said individual an antibody which specifically binds to p185.   
   
   
       2 . The method of  claim 1  wherein the antibody has the complementarity determining regions from an antibody selected from the group consisting of 7.16.4 and 7.9.5. 
   
   
       3 . The method of  claim 1  wherein the antibody has the variable region from an antibody selected from the group consisting of 7.16.4 and 7.9.5. 
   
   
       4 . The method of  claim 1  wherein the antibody is selected from the group consisting of 7.16.4 and 7.9.5. 
   
   
       5 . The method of  claim 1  wherein the antibody is 7.16.4. 
   
   
       6 . The method of  claim 1  wherein the antibody is a humanized antibody with complementarity determining regions selected from an antibody the group consisting of 7.16.4 and 7.9.5. 
   
   
       7 . The method of  claim 1  wherein the antibody is a humanized antibody with complementarity determining regions from antibody 7.16.4. 
   
   
       8 . The method of  claim 1  wherein the antibody is a humanized antibody with variable regions selected from an antibody the group consisting of 7.16.4 and 7.9.5. 
   
   
       9 . The method of  claim 1  wherein the antibody is a humanized antibody with variable regions from antibody 7.16.4. 
   
   
       10 . The method of  claim 1  further comprising administering to said individual a second antibody which specifically binds to p185. 
   
   
       11 . The method of  claim 1  further comprising administering to said individual an anti-tumor agent. 
   
   
       12 . A method of preventing transformation of a normal cell into a tumor cell that has p185 on its surface in individual who has had a tumor that has p185 on its cell surfaces removed or who has had cancer characterized by tumor cells that have p185 on their surfaces enter remission comprising the steps of:
 a) identifying said individual; and,   b) administering to said individual an antibody which specifically binds to p185.   
   
   
       13 . The method of  claim 12  wherein the antibody has the complementarity determining regions from an antibody selected from the group consisting of 7.16.4 and 7.9.5. 
   
   
       14 . The method of  claim 12  wherein the antibody has the variable region from an antibody selected from the group consisting of 7.16.4 and 7.9.5. 
   
   
       15 . The method of  claim 12  wherein the antibody is selected from the group consisting of 7.16.4 and 7.9.5. 
   
   
       16 . The method of  claim 12  wherein the antibody is 7.16.4. 
   
   
       17 . The method of  claim 12  wherein the antibody is a humanized antibody with complementarity determining regions selected from an antibody the group consisting of 7.16.4 and 7.9.5. 
   
   
       18 . The method of  claim 12  wherein the antibody is a humanized antibody with complementarity determining regions from antibody 7.16.4. 
   
   
       19 . The method of  claim 12  wherein the antibody is a humanized antibody with variable regions selected from an antibody the group consisting of 7.16.4 and 7.9.5. 
   
   
       20 . The method of  claim 12  wherein the antibody is a humanized antibody with variable regions from antibody 7.16.4. 
   
   
       21 . The method of  claim 12  further comprising administering to said individual a second antibody which specifically binds to p185. 
   
   
       22 . The method of  claim 12  further comprising administering to said individual an anti-tumor agent.

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