US2010029920A1PendingUtilityA1

Method for assessing the effect of a drug on long term memory formation

62
Individually held — no corporate assignee on recordPriority: Oct 7, 1994Filed: Jul 16, 2009Published: Feb 4, 2010
Est. expiryOct 7, 2014(expired)· nominal 20-yr term from priority
Inventors:Timothy P. TullyJerry Yin
A01K 67/68A61K 38/00C07K 14/435A61C 9/0026C12N 9/0075Y10T436/105831A61K 49/0008C07K 14/4705A01K 2217/05A01K 2267/0356C07K 14/4703A01K 2227/706A01K 2267/00C07K 2319/00
62
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Claims

Abstract

Methods of assessing the effect of a drug on long term memory and for screening a pharmaceutical agent for its ability to modulate long term memory are disclosed.

Claims

exact text as granted — not AI-modified
1 - 74 . (canceled) 
     
     
         75 . An isolated DNA encoding an activator associated with the potentiation of long term memory, wherein the activator comprises a CREB/CREM/ATF-1 subfamily member. 
     
     
         76 . An isolated DNA encoding a repressor associated with blocking long term memory, wherein the repressor comprises an antagonist of the activator of  claim 75 . 
     
     
         77 . An isolated DNA which hybridizes under high stringency conditions to a nucleotide sequence selected from the group consisting of SEQ ID NO: 1 and SEQ ID NO: 7. 
     
     
         78 . An isolated activator associated with the potentiation of long term memory, wherein the activator comprises a CREB/CREM/ATF-1 subfamily member. 
     
     
         79 . An isolated repressor associated with blocking long term memory, wherein the repressor comprises an antagonist of the activator of  claim 78 .

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