Compositions and methods for the prevention of cardiovascular disease

Abstract

The present invention relates to compositions comprising vitamins, minerals and other nutrients and methods for using these compositions for nutritional supplementation to prevent and/or alleviate a patient from the occurrence or negative effects of cardiovascular disease. Specifically, the invention relates to compositions and methods of administering compositions comprising natural CoQ 10 , natural Omega-3 fatty acids, natural bioflavonoids, natural vitamin E, amino acids and derivatives thereof, minerals, extra virgin olive oil, lecithin, B-complex vitamins, and antioxidants.

1 . A composition comprising natural CoQ 10 , natural omega-3 fatty acids, natural bioflavonoids, natural vitamin E, amino acids and derivatives thereof, minerals, extra virgin olive oil, lecithin, B-complex vitamins, and antioxidants, which is administrable to a patient in need thereof. 
   
   
       2 . The composition of  claim 1 , wherein said B-complex vitamins are selected from one or more of the group consisting of vitamin B 1 , vitamin B 2 , vitamin B 3 , vitamin B 5 , vitamin B 6 , vitamin B 7 , vitamin B 9  and vitamin B 12 . 
   
   
       3 . The composition of  claim 2 , wherein said vitamin B 3  is selected from one or more of the group consisting of nicotinic acid and niacinamide ascorbate. 
   
   
       4 . The composition of  claim 2 , wherein said vitamin B 6  comprises pyridoxine. 
   
   
       5 . The composition of  claim 2 , wherein said vitamin B 9  comprises folic acid. 
   
   
       6 . The composition of  claim 2 , wherein said vitamin B 12  comprises cyanocobalamin. 
   
   
       7 . The composition of  claim 1 , wherein said omega-3 fatty acids are selected from one or more of the group consisting of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), α-linolenic acid, stearidonic acid, eicosatetraenoic acid, docosapentaenoic acid, octadecatrienoic acid and octadecatetraenoic acid. 
   
   
       8 . The composition of  claim 1 , wherein said natural bioflavonoids are extracted from a natural source selected from one or more of the group consisting of grape seeds, onions, parsley, legumes, green tea, and citrus fruits. 
   
   
       9 . The composition of  claim 1 , wherein said natural bioflavonoids are selected from one or more of the group consisting of oligomeric proanthocyanidins (OPC's), epicatechin, genistein, hesperidin, quercetin, rutin, narirutin, naringin, hesperetin, neohesperidin, tangeretin, nobiletin and sinensetin. 
   
   
       10 . The composition of  claim 1 , wherein said minerals are chelated, and selected from one or more of the group consisting of magnesium, zinc, calcium, phosphorous, copper, manganese, chromium, selenium, sodium, potassium, chloride, and iron. 
   
   
       11 . The composition of  claim 10 , wherein said magnesium is chelated to an amino acid. 
   
   
       12 . The composition of  claim 10 , wherein said selenium comprises L-Seleno-Methionine. 
   
   
       13 . The composition of  claim 1 , wherein said vitamin E is selected from one or more of the group consisting of natural tocopherols and natural tocotrienols. 
   
   
       14 . The composition of  claim 13 , wherein said natural tocopherol are mixed and selected from one or more of the group consisting of gamma tocopherol, delta tocopherol, beta tocopherol and alpha tocopherol. 
   
   
       15 . The composition of  claim 13 , wherein said natural tocotrienols are mixed and selected from one or more of the group consisting of gamma tocotrienol, delta tocotrienol and alpha tocotrienol. 
   
   
       16 . The composition of  claim 1 , wherein said amino acids or derivatives thereof are selected from one or more of the group consisting of proline, phenylalanine, methionine, threonine, tryptophan, histidine, isoleucine, leucine, asparagine, aspartic acid, glutamic acid, glutamine, serine, tyrosine, valine, lysine, alanine, glycine, tryptophan, cysteine, TMG (trimethyl glycine/Betaine, L-taurine, L-carnitine, acetyl-L-carnitine, N,N-dimethyl glycine and N-acetylcysteine. 
   
   
       17 . The composition of  claim 1 , wherein said antioxidants are selected from one or more of the group consisting of vitamin C (ascorbic acid), alpha-lipoic acid, ascorbyl palmitate, butylated hydroxyanisole, butylated hydroxytoluene, hypophophorous acid, monothioglycerol, propyl gallate, sodium ascorbate, sodium bisulfite, sodium formaldehyde sulfoxylate, sodium metabisulfite, pycnogenol, superoxide dismutase, pine bark grape seed complex, garlic, carotenoids, choline, metabisulfite, catechin, glangin, rutin, luteolin, morin, fisetin, silymerin, ascorbyl palmitate, apigenin, gingkolides, hesperitin, cyanidin, citrin sodium bisulfite or mixtures thereof. 
   
   
       18 . The composition of  claim 17 , wherein said vitamin C comprises calcium ascorbate. 
   
   
       19 . The composition of  claim 1 , wherein said composition is substantially free of other added vitamins and nutrients. 
   
   
       20 . The composition of  claim 1 , further comprising a pharmaceutically acceptable carrier. 
   
   
       21 . The composition of  claim 20 , wherein said pharmaceutically acceptable carrier is selected from one or more of the group consisting of binders, diluents, lubricants, glidants, colorants, emulsifiers, disintegrants, starches, water, oils, alcohols, preservatives and sugars. 
   
   
       22 . The composition of  claim 1 , wherein said omega-3 fatty acids consist of natural DHA omega-3 and natural EPA omega-3, said bioflavonoids consist of natural grape seed extract bioflavonoids or OPC's, said vitamin E consists of natural mixed tocotrienols, natural alpha tocotrienol, natural delta tocotrienol, natural gamma tocotrienol, natural mixed tocopherols, natural beta tocopherol, natural alpha tocopherol, natural delta tocopherol and natural gamma tocopherol, said amino acids and derivatives thereof consist of L-taurine, TMG (trimethyl glycine/Betaine), L-carnitine, and acetyl-L-carnitine, said minerals consist of magnesium and L-Seleno-Methionine, said B-complex vitamins consist of cyanocobalamin, pyridoxine, niacinimide ascorbate, nicotinic acid, and folic acid, and said antioxidants consist of calcium ascorbate and alpha-lipoic acid. 
   
   
       23 . The composition of  claim 22 , wherein said composition comprises about 75 mg to about 25 mg lecithin; about 112.5 mg to about 322.5 mg extra virgin olive oil; about 12.5 mg to about 37.5 mg L-taurine; about 25 mg to about 75 mg TMG; about 25 mg to about 75 mg L-carnitine; about 6.25 mg to about 18.75 mg acetyl-L-carnitine; about 25 mcg to about 75 mcg L-Seleno-Methionine; about 50 mg to about 150 mg magnesium chelated to an amino acid; about 25 mcg to about 75 mcg cyanocobalamin; about 12.5 mg to about 37.5 mg pyridoxine; about 6.25 mg to about 18.75 mg niacinimide ascorbate; about 6.25 mg to about 18.75 mg nicotinic acid; about 0.25 mg to about 0.75 mg folic acid; about 30 mg to about 90 mg DHA omega-3; about 45 mg to about 135 mg EPA omega-3; about 125 mg to about 375 mg calcium ascorbate; about 12.5 mg to about 37.5 mg alpha-lipoic acid; about 25 mg to about 75 mg grape seed extract bioflavonoids or OPC's; about 37 mcg to about 112 mcg alpha tocotrienol; about 62.5 mcg to about 187.5 mcg delta tocotrienol; about 0.5 mcg to about 1.7 mcg gamma tocotrienol; about 12.5 mg to about 37.5 mg mixed tocotrienols; about 1.5 IU to about 4.5 IU beta tocopherol; about 15 IU to about 45 IU alpha tocopherol; about 24 IU to about 72 IU delta tocopherol; about 90 IU to about 270 IU gamma tocopherol; about 150 IU to about 450 IU of mixed tocopherols; and about 15 mg to about 45 mg CoQ 10 . 
   
   
       24 . The composition of  claim 22 , wherein said composition comprises about 50 mg lecithin; about 215 mg extra virgin olive oil; about 25 mg L-taurine; about 50 mg TMG; about 50 mg L-carnitine; about 12.5 mg acetyl-L-carnitine; about 50 mcg L-Seleno-Methionine; about 100 mg magnesium chelated to an amino acid; about 50 mcg cyanocobalamin; about 25 mg pyridoxine; about 12.5 mg niacinimide ascorbate; about 12.5 mg nicotinic acid; about 0.5 mg folic acid; about 60 mg DHA omega-3; about 90 mg EPA omega-3; about 250 mg calcium ascorbate; about 25 mg alpha lipoic acid; about 50 mg grape seed extract bioflavonoids or OPC's; about 75 mcg alpha tocotrienol; about 125 mcg delta tocotrienol; about 1.1 mcg gamma tocotrienol; about a total of 25 mg mixed tocotrienols; about 3 IU beta tocopherol; about 30 IU alpha tocopherol; about 48 IU delta tocopherol; about 180 IU gamma tocopherol; about a total of 300 IU mixed tocopherols; and about 30 mg CoQ 10 . 
   
   
       25 . The composition of  claim 1  wherein said composition is administered to said patient orally. 
   
   
       26 . The composition of  claim 1 , wherein said composition is in the dosage form of a softgel. 
   
   
       27 . The composition of  claim 1 , wherein said composition is administered to said patient to prevent and/or alleviate the occurrence or negative effects of cardiovascular disease. 
   
   
       28 . A method comprising administering the composition of  claim 1  to a patient. 
   
   
       29 . The method of  claim 28 , wherein said B-complex vitamins are selected from one or more of the group consisting of vitamin B 1 , vitamin B 2 , vitamin B 3 , vitamin B 5 , vitamin B 6 , vitamin B 7 , vitamin B 9  and vitamin B 12 . 
   
   
       30 . The method of  claim 29 , wherein said vitamin B 3  is selected from one or more of the group consisting of nicotinic acid and niacinamide ascorbate. 
   
   
       31 . The method of  claim 29 , wherein said vitamin B 6  comprises pyridoxine. 
   
   
       32 . The method of  claim 29 , wherein said vitamin B 9  comprises folic acid. 
   
   
       33 . The method of  claim 29 , wherein said vitamin B 12  comprises cyanocobalamin. 
   
   
       34 . The method of  claim 28 , wherein said natural omega-3 fatty acids are selected from one or more of the group consisting of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), α-linolenic acid, stearidonic acid, eicosatetraenoic acid, docosapentaenoic acid, octadecatrienoic acid and octadecatetraenoic acid. 
   
   
       35 . The method of  claim 28 , wherein said natural bioflavonoids are extracted from a natural source selected from one or more of the group consisting of grape seeds, onions, parsley, legumes, green tea, and citrus fruits. 
   
   
       36 . The method of  claim 35 , wherein said natural bioflavonoids comprises grape seed extract. 
   
   
       37 . The method of  claim 28 , wherein said natural bioflavonoids are selected from one or more of the group consisting of oligomeric proanthocyanidins (OPC's), epicatechin, genistein, hesperidin, quercetin, rutin, narirutin, naringin, hesperetin, neohesperidin, tangeretin, nobiletin and sinensetin. 
   
   
       38 . The method of  claim 28 , wherein said minerals are chelated and selected from one or more of the group consisting of magnesium, zinc, calcium, phosphorous, copper, manganese, chromium, selenium, sodium, potassium, chloride, and iron. 
   
   
       39 . The method of  claim 38 , wherein said magnesium is chelated to an amino acid. 
   
   
       40 . The method of  claim 38 , wherein said selenium comprises L-Seleno-Methionine. 
   
   
       41 . The method of  claim 28 , wherein said vitamin E is selected from one or more of the group consisting of natural tocopherols and natural tocotrienols. 
   
   
       42 . The method of  claim 41 , wherein said natural tocopherol is mixed and selected from one or more of the group consisting of gamma tocopherol, delta tocopherol, beta tocopherol and alpha tocopherol. 
   
   
       43 . The method of  claim 41 , wherein said natural tocotrienols are mixed and selected from one or more of the group consisting of gamma tocotrienol, delta tocotrienol and alpha tocotrienol. 
   
   
       44 . The method of  claim 28 , wherein said amino acids or derivatives thereof are selected from one or more of the group consisting of proline, phenylalanine, methionine, threonine, tryptophan, histidine, isoleucine, leucine, asparagine, aspartic acid, glutamic acid, glutamine, serine, tyrosine, valine, lysine, alanine, glycine, tryptophan, cysteine, TMG (trimethyl glycine/Betaine), L taurine, L-carnitine, acetyl-L-carnitine, N,N-dimethyl glycine and N-acetylcysteine. 
   
   
       45 . The method of  claim 28 , wherein said antioxidants are selected from one or more of the group consisting of vitamin C (ascorbic acid), alpha-lipoic acid, ascorbyl palmitate, butylated hydroxyanisole, butylated hydroxytoluene, hypophophorous acid, monothioglycerol, propyl gallate, sodium ascorbate, sodium bisulfite, sodium formaldehyde sulfoxylate, sodium metabisulfite, pycnogenol, superoxide dismutase, pine bark grape seed complex, garlic, carotenoids, choline, metabisulfite, catechin, glangin, rutin, luteolin, morin, fisetin, silymerin, ascorbyl palmitate, apigenin, gingkolides, hesperitin, cyanidin, citrin sodium bisulfite or mixtures thereof. 
   
   
       46 . The method of  claim 45 , wherein said vitamin C comprises calcium ascorbate. 
   
   
       47 . The method of  claim 28 , wherein said composition is substantially free of other added vitamins and nutrients. 
   
   
       48 . The method of  claim 28 , further comprising a pharmaceutically acceptable carrier. 
   
   
       49 . The method of  claim 48 , wherein said pharmaceutically acceptable carrier is selected from one or more of the group consisting of binders, diluents, lubricants, glidants, colorants, emulsifiers, disintegrants, starches, water, oils, alcohols, preservatives and sugars. 
   
   
       50 . The method of  claim 28 , wherein said omega-3 fatty acids consist of natural DHA omega-3 and natural EPA omega-3, said bioflavonoids consist of natural grape seed extract bioflavonoids or OPC's, said vitamin E consists of natural mixed tocotrienols, natural alpha tocotrienol, natural delta tocotrienol, natural gamma tocotrienol, natural mixed tocopherols, natural beta tocopherol, natural alpha tocopherol, natural delta tocopherol and natural gamma tocopherol, said amino acids and derivatives thereof consist of L-taurine, TMG (trimethyl glycine/Betaine), L-carnitine, and acetyl-L-carnitine, said minerals consist of magnesium and L-Seleno-Methionine, said B-complex vitamins consist of cyanocobalamin, pyridoxine, niacinimide ascorbate, nicotinic acid, and folic acid, and said antioxidants consist of calcium ascorbate and alpha-lipoic acid. 
   
   
       51 . The method of  claim 50 , wherein said composition comprises about 75 mg to about 25 mg lecithin; about 112.5 mg to about 322.5 mg extra virgin olive oil; about 12.5 mg to about 37.5 mg L-taurine; about 25 mg to about 75 mg TMG; about 25 mg to about 75 mg L-carnitine; about 6.25 mg to about 18.75 mg acetyl-L-carnitine; about 25 mcg to about 75 mcg L-Seleno-Methionine; about 50 mg to about 150 mg magnesium chelated to an amino acid; about 25 mcg to about 75 mcg cyanocobalamin; about 12.5 mg to about 37.5 mg pyridoxine; about 6.25 mg to about 18.75 mg niacinimide ascorbate; about 6.25 mg to about 18.75 mg nicotinic acid; about 0.25 mg to about 0.75 mg folic acid; about 30 mg to about 90 mg DHA omega-3; about 45 mg to about 135 mg EPA omega-3; about 125 mg to about 375 mg calcium ascorbate; about 12.5 mg to about 37.5 mg alpha-lipoic acid; about 25 mg to about 75 mg grape seed extract bioflavonoids or OPC's; about 37 mcg to about 112 mcg alpha tocotrienol; about 62.5 mcg to about 187.5 mcg delta tocotrienol; about 0.5 mcg to about 1.7 mcg gamma tocotrienol; about 12.5 mg to about 37.5 mg mixed tocotrienols; about 1.5 IU to about 4.5 IU beta tocopherol; about 15 IU to about 45 IU alpha tocopherol; about 24 IU to about 72 IU delta tocopherol; about 90 IU to about 270 IU gamma tocopherol; about 150 IU to about 450 IU of mixed tocopherols; and about 15 mg to about 45 mg CoQ 10 . 
   
   
       52 . The method of  claim 50 , wherein said composition comprises about 50 mg lecithin; about 215 mg extra virgin olive oil; about 25 mg L-taurine; about 50 mg TMG; about 50 mg L-carnitine; about 12.5 mg acetyl-L-carnitine; about 50 mcg L-Seleno-Methionine; about 100 mg magnesium chelated to an amino acid; about 50 mcg cyanocobalamin; about 25 mg pyridoxine; about 12.5 mg niacinimide ascorbate; about 12.5 mg nicotinic acid; about 0.5 mg folic acid; about 60 mg DHA omega-3; about 90 mg EPA omega-3; about 250 mg calcium ascorbate; about 25 mg alpha lipoic acid; about 50 mg grape seed extract bioflavonoids or OPC's; about 75 mcg alpha tocotrienol; about 125 mcg delta tocotrienol; about 1.1 mcg gamma tocotrienol; about a total of 25 mg mixed tocotrienols; about 3 IU beta tocopherol; about 30 IU alpha tocopherol; about 48 IU delta tocopherol; about 180 IU gamma tocopherol; about a total of 300 IU mixed tocopherols; and about 30 mg CoQ 10 . 
   
   
       53 . The method of  claim 28 , wherein said composition is administered to said patient orally. 
   
   
       54 . The method of  claim 28 , wherein said composition is in the form of a softgel. 
   
   
       55 . The method of  claim 28 , wherein said composition is administered to said patient to prevent and/or alleviate the occurrence or negative effects of cardiovascular disease. 
   
   
       56 . The method of  claim 28 , wherein said composition is administered to said patient once a day. 
   
   
       57 . The method of  claim 28 , wherein said composition is administered to said patient twice a day.