US2010021548A1PendingUtilityA1

Use of microparticles with adsorbed antigen to stimulate immune responses

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Assignee: NOVARTIS VACCINES & DIAGNOSTICPriority: Jan 30, 1997Filed: Oct 6, 2009Published: Jan 28, 2010
Est. expiryJan 30, 2017(expired)· nominal 20-yr term from priority
Inventors:Derek O'HaganGary Van NestGary S. OttJohn BarackmanJina Kazzaz
A61K 9/167A61K 2039/54A61P 31/12C12N 2740/16234C12N 2710/16634A61K 2039/55555A61K 2039/545A61K 39/12C12N 2760/16134A61K 39/245A61K 39/21A61K 39/145A61K 9/1647A61P 31/16A61P 37/04A61K 39/39Y02A50/30
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Claims

Abstract

The use of poly(lactide) or poly(lactide-co-glycolide) microparticles with adsorbed antigen is disclosed. The microparticles are useful for enhancing CTL responses to a selected antigen.

Claims

exact text as granted — not AI-modified
1 . A composition comprising an antigen derived from a pathogen adsorbed to a microparticle that comprises a poly(α-hydroxy acid); and a pharmaceutically acceptable excipient. 
   
   
       2 . The composition of  claim 1 , wherein said antigen is derived from a viral pathogen. 
   
   
       3 . The composition of  claim 2 , wherein the microparticle comprises a poly(α-hydroxy acid) selected from the group consisting of poly(L-lactide), poly(D,L-lactide) and poly(D,L-lactide-co-glycolide). 
   
   
       4 . The composition of  claim 3 , wherein the microparticle comprises poly(D,L-lactide-co-glycolide). 
   
   
       5 . The composition of  claim 2 , wherein the antigen comprises HIV gp120. 
   
   
       6 . The composition of  claim 2 , wherein the antigen comprises HIV p24gag. 
   
   
       7 . The composition of  claim 2 , wherein the antigen comprises Influenza A hemagglutinin antigen. 
   
   
       8 . The composition of  claim 2 , wherein said antigen comprises a hepatitis B viral antigen. 
   
   
       9 . The composition of  claim 2 , wherein said antigen comprises a hepatitis C viral antigen. 
   
   
       10 . The composition of  claim 2 , wherein said antigen comprises an influenza A viral antigen. 
   
   
       11 . The composition of  claim 2 , wherein said antigen comprises an HIV antigen. 
   
   
       12 . The composition of  claim 2 , wherein said composition is an injectable composition. 
   
   
       13 . The composition of  claim 2 , wherein said composition further comprises an immunological adjuvant. 
   
   
       14 . The composition of  claim 13 , wherein the immunological adjuvant comprises a monophosphorylipid A compound. 
   
   
       15 . The composition of  claim 2 , wherein the microparticle has a diameter between 500 nanometers and 10 microns. 
   
   
       16 . The composition of  claim 2 , wherein the microparticle comprises a poly(lactide-co-glycolide). 
   
   
       17 . The composition of  claim 16 , wherein said poly(lactide-co-glycolide) contains 50% D,L-lactide and 50% glycolide.

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