Method to reduce the physiologic effects of drugs on mammals

Abstract

A method to reduce the physiologic effects of drugs in vivo by inducing specific anti-drug antibodies using drugs conjugated to carrier molecules so as to reduce a drug's toxicity and its physiologic effects upon the recipient. This method includes the treatment and prophylactic prevention of drug abuse, specifically for cocaine and nicotine, and to help reduce the toxic effects of drugs, such as anti-neoplastics.

1 .- 20 . (canceled) 
   
   
       21 . A pharmaceutical composition comprising a pharmaceutically acceptable carrier, and a drug conjugated immunogen, wherein the drug is cocaine or a derivative thereof, and the drug is conjugated to a carrier which is capable of eliciting an immune response. 
   
   
       22 . A pharmaceutical composition comprising a pharmaceutically acceptable carrier, and a drug conjugated immunogen, wherein the drug is selected from the group comprising of heroin, opium, morphine, marijuana, or a derivative thereof, and the drug is conjugated to a carrier which is capable of eliciting an immune response. 
   
   
       23 . The pharmaceutical composition of  claim 21  or  22 , wherein the drug is conjugated to a bacterial toxoid. 
   
   
       24 . The pharmaceutical composition of  claim 21  or  22 , which is suitable for oral, inhalation or injection administration to a human. 
   
   
       25 . The pharmaceutical composition of  claim 21  or  22 , which is suitable for subcutaneous administration to a human. 
   
   
       26 . The composition of  claim 21  or  22 , further comprising aluminum hydroxide. 
   
   
       27 . A method of treating or preventing cocaine abuse in humans, the method comprising administration of a pharmaceutical composition comprising a pharmaceutically acceptable carrier, and a drug conjugated immunogen, wherein the drug is cocaine or a derivative thereof, and the drug is conjugated to a carrier which is capable of eliciting an immune response. 
   
   
       28 . A method of treating or preventing abuse of a controlled substance in humans, the method comprising administration of a pharmaceutical composition comprising a pharmaceutically acceptable carrier, and a drug conjugated immunogen, wherein the drug is selected from the group comprising of heroin, opium, morphine, marijuana, or a derivative thereof, and the drug is conjugated to a carrier which is capable of eliciting an immune response. 
   
   
       29 . The method of  claim 27  or  28 , wherein the drug is conjugated to a bacterial toxoid. 
   
   
       30 . The method of  claim 27  or  28 , wherein the composition is administered orally, by inhalation or by injection. 
   
   
       31 . The method of  claim 27  or  28 , wherein the composition is administered subcutaneously. 
   
   
       32 . The method of  claim 27  or  28 , wherein the composition further comprises aluminum hydroxide.