Peptides binding the phosphatase 2a protein

Abstract

The invention relates to novel synthetic or natural E4orf4 or Bcl-2 peptides particularly useful in antitumoral, antiviral and antiparasitic treatments, said peptides being less than 30 amino acids long and binding in vitro to a phosphatase 2A protein holoenzyme or one of its subunits. The invention also relates to polynucleotides encoding the novel peptides, vectors expressing same, as well as antibodies identifying same and probes identifying transcripts thereof.

1 - 23 . (canceled) 
     
     
         24 . An isolated peptide that is at least 90% identical with a complete amino acid sequence of 
       
         
           
                 
                 
                 
               
                   VKKKKIKREIKI SMLE SPMEFLFDTI DDVT. 
                   (SEQ. ID NO: 6) 
                     
                 
                   AS. 
                 
             
                
                
               
            
           
         
       
     
     
         25 . A composition comprising the isolated peptide of  claim 24  and a pharmaceutically acceptable carrier. 
     
     
         26 . A composition comprising the isolated peptide of  claim 24  coupled to a vector which can transfer said peptide into a eukaryotic cell. 
     
     
         27 . The isolated peptide of  claim 24 , wherein the peptide specifically binds a phosphatase 2A protein holoenzyme or one of its subunits in vitro.