US2010003215A1PendingUtilityA1

Culturing circular ssDNA viruses for the production of vaccines

Assignee: NAUWYNCK HANSPriority: Feb 3, 2005Filed: Jan 23, 2009Published: Jan 7, 2010

Est. expiryFeb 3, 2025(expired)· nominal 20-yr term from priority

Inventors:Hans Nauwynck Gerald Misinzo Sven Arnouts

C12N 2750/10034C12N 7/00A61K 2039/5254A61K 39/39A61K 39/12A61P 37/04A61K 2039/552A61K 2039/55522A61P 31/12A61K 38/21

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Claims

Abstract

The present invention relates to the use of interferon in the in vitro cultivation of animal circular ssDNA virus such as Porcine Circovirus 2 or human TT virus in an animal cell line.

Claims

exact text as granted — not AI-modified

1 . A vaccine comprising an attenuated animal circular ssDNA virus and interferon. 
   
   
       2 . An undiluted medium of an in vitro culture of a cell-line comprising animal circular ssDNA virus characterized in that it further comprises at least 2 U/ml interferon. 
   
   
       3 . An undiluted medium of an in vitro culture of a cell-line comprising animal circular ssDNA virus characterized in that it further comprises an agent capable of inhibiting endosomal-lysosomal system acidification.

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