US2009324748A1PendingUtilityA1

Trauma therapy

54
Assignee: HIBERNATION THERAPEUTICS LTDPriority: Jul 25, 2006Filed: Jul 25, 2007Published: Dec 31, 2009
Est. expiryJul 25, 2026(expired)· nominal 20-yr term from priority
Inventors:Geoffrey Philip Dobson
A61P 9/00A61P 7/08A61P 43/00A61P 9/02A61P 9/10A61K 45/06A61K 38/28A61K 31/7076A61K 9/0019A61K 31/167A61P 17/02A61K 31/4045A61P 23/02A61K 47/02A61K 33/06
54
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Claims

Abstract

The invention provides a method of reducing injury to cells, tissues or organs of a body following trauma by administering a composition to the body following trauma, including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and (ii) a local anaesthetic. Also provided is a composition for reducing injury to cells, tissues or organs of a body following trauma including: (i) and (ii). The composition may be hypertonic.

Claims

exact text as granted — not AI-modified
1 . A method of reducing injury to cells, tissues or organs of a body following trauma by administering a composition to the body following trauma, including:
 (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and   (ii) a local anaesthetic.   
   
   
       2 . A method according to  claim 1  wherein a further composition including (i) and (ii) is administered following administration of the composition. 
   
   
       3 . A method according to  claim 1  wherein the composition further includes divalent magnesium cations. 
   
   
       4 . A method according to  claim 3  wherein the concentration of magnesium is up to about 2.5 mM. 
   
   
       5 . A method according to  claim 1  wherein the composition is hypertonic. 
   
   
       6 . A composition for reducing injury to cells, tissues or organs of a body following trauma including:
 (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and   (ii) a local anaesthetic.   
   
   
       7 . A composition according to  claim 6 , further including divalent magnesium cations. 
   
   
       8 . A composition according to  claim 6  which is hypertonic. 
   
   
       9 . A method of treating a trauma victim by administering a composition, including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and (ii) a local anaesthetic. 
   
   
       10 . A method of treating a trauma victim by administering a composition according to  claim 6 . 
   
   
       11 . A composition according to  claim 7 , wherein the concentration of magnesium is up to about 2.5 mM.

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