US2009312554A1PendingUtilityA1

Novel Process for the Preparation of Hexacyclic Compounds

63
Assignee: CHUGAI PHARMACEUTICAL CO LTDPriority: Feb 21, 2003Filed: Aug 25, 2009Published: Dec 17, 2009
Est. expiryFeb 21, 2023(expired)· nominal 20-yr term from priority
Inventors:Hiroshi FukudaTakeshi MurataSatoshi NiizumaHitomi SudaMasao Tsukazaki
A61P 35/00C07D 491/14
63
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Claims

Abstract

This invention relates to novel processes for the preparation of compounds of the formula [1], wherein R 1 , R 2 , R 3 and R 4 are as defined in the claims and description as well as pharmaceutically acceptable salts thereof. The compounds of the formula [ 1 ] are hexacyclic compounds having potent anti-tumor activity.

Claims

exact text as granted — not AI-modified
1 . A compound of formula [3]: 
       
         
           
           
               
               
           
         
       
       wherein R 6  is chlorine or bromine. 
     
     
         2 . A compound according to  claim 1 , which is (4S)-6-chloro-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]-indolizine-3,6,10(4H)-trione. 
     
     
         3 . A process for the preparation of a compound of  claim 1 , which comprises halogenating a compound of the formula [8]: 
       
         
           
           
               
               
           
         
       
       in order to obtain compound of the formula [3]: 
       
         
           
           
               
               
           
         
       
       wherein R 6  is chlorine or bromine.

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