Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents

Abstract

Oxadiazolyl-phenoxyalkylisoxazoles and pharmaceutically acceptable salts thereof, compositions comprising oxadiazolyl-phenoxyalkylisoxazole compounds or pharmaceutically acceptable salts thereof and methods for using oxadiazolyl-phenoxyalkylisoxzazole compounds or pharmaceutically acceptable salts thereof as anti-picornaviral agents are described herein. The methods include using pleconaril as a prodrug for conversion to anti-picornaviral compounds in vivo.

1 .- 19 . (canceled) 
   
   
       20 . A method for preventing a picornaviral infection in a patient, said method comprising administering to a patient in need of such prevention an effective amount of the compound of Formula I: 
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable salt thereof. 
   
   
       21 . A method for preventing a picornaviral infection in a patient, said method comprising administering to a patient in need of such prevention an effective amount of the compound of Formula II: 
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable salt thereof. 
   
   
       22 . A method according to  claim 20 , wherein a precursor of said compound is administered in the form of a prodrug. 
   
   
       23 . A method according to  claim 21 , wherein a precursor of said compound is administered in the form of a prodrug. 
   
   
       24 . A method according to  claim 22 , wherein said prodrug is pleconaril. 
   
   
       25 . A method according to  claim 23 , wherein said prodrug is pleconaril. 
   
   
       26 . A method of using pleconaril as a prodrug for preventing picornaviral infections in a patient, said method comprising administering to said patient an effective amount of pleconaril or a pharmaceutically acceptable salt thereof.