Method of treating of demyelinating diseases or conditions

Abstract

N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.

1 . A method for treating multiple sclerosis, in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound of formula 
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable salt thereof. 
   
   
       2 . The method according to  claim 1 , wherein the pharmaceutically acceptable salt is hydrochloride salt.